Dr. Sundararajan Madihally

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Oklahoma State University
College of Engineering, Architecture and Technology
Chemical Engineering
Associate ProfessorAppointed: 2008
Professional Headshot of Sundararajan Madihally

Mailing Address

423 Engineering North
Stillwater, Oklahoma 74078
United States

Contact Information

Phone: (405) 744-5280
Fax: (405) 744-6338
sundar.madihally@okstate.edu

Qualifications

Research Fellowship, Harvard University, Surgical Services, 2001.
Research Fellowship, Massachusetts General Hospital, Surgical Services, 2001.
Ph.D., Wayne State University, Chemical Engineering, 1998.
M.S., Wayne State University, Chemical Engineering, 1996.

Expertise and Research Interests

Cell and Tissue Engineering
Stem Cells
Novel Therapies for Traumatic Conditions

Future Research

The focus of the laboratory is to engineer and evaluate molecular mechanisms in cells, tissues, and organs. It is a multidisciplinary research with personnel from various backgrounds. The applications of these processes are in a wide array of disciplines such as biotechnology, chemical engineering, immunology, molecular biology, pathology, polymer science, and surgical services. We are working on a number of projects in collaboration with various investigators throughout the world. Some of the projects are 1) colonization of mature and immature (stem cells from differnt lineages) on three dimensional porous structures, 2) processes to develop customized scaffolds, 3) muscle wasting and immunedysfuction mechanism and therapy, 4) drug delivery approaches, 5) bioreactor design for regenerating tissues and useful biomolecules, and 6) novel educational methods to integrate cutting edge techologies. Click on a project of interest at madihally.okstate.edu to learn more.

Keywords

COS Keywords:

Biomedical Engineering, Chemical Engineering, Engineering Education, Stem Cells, Surgery, Tissue Engineering.

Additional Terms:

Stem Cell Tissue Engineering.

Memberships

American Institute of Chemical Engineers
American Society for Engineering Education
Biomedical Engineering Society

Honors and Awards

2008, Golden Torch Award, Mortar Board, Oklahoma State University, College of Engineering Architecture and Technology
2008, Best Poster Award (along with Dr. Eric Maase), American Society of Engineering Educators, Chemical Engineering Division
2008, International Editorial Board Member, Biomaterials Journal
2005-2006, Teacher of the Year, Chemical Engineering Department, Oklahoma State University
2004-2005, Student Organization Advisor of the Year Award, Oklahoma State University
2004-2005, Halliburton Excellent Young Teacher Award, Oklahoma State University, College of Engineering, Architecture, and Technology
2002, Omega Chi Epsilon, Chemcial Engineering Honor Society
1997, Tau Beta Pi, Engineering Honor Society
1992, First Rank, Bangalore University, Chemical Engineering

Previous Positions

2002-2008, Assistant Professor, Oklahoma State University, College of Engineering, Architecture and Technology, Chemical Engineering
2001-2002, Visiting Assistant Professor, Rutgers, The State University of New Jersey, School of Engineering, Biomedical Engineering
1998-2002, Research Fellow, Shriners Hospital for Children, Surgical Services
1998-2002, Research Fellow, Harvard University, Medical School, Surgical Services

Funding Received

  • National Institutes of Health (NIH): Synthetic Scaffolds for Bladder Regeneration, 2007 to 2009.
  • National Institutes of Health (NIH): Design of Chemical Penetration Enhancers for Transdermal Drug Delivery, 2006 to 2008.
  • Oklahoma State Regents for Higher Education: NIH-OK INBRE Summer Research Program for Undergraduates, 2005 to 2006.
  • Oklahoma Health Research Program: Tissue Engineering Scaffolds for Bladder Reconstruction, 2005 to 2008.
  • Oral Research Advancing the Life Sciences NIH-COBRE Program: Characterization of chitosan-based scaffolds for periodontal tissue engineering, 2004 to 2005.
  • Oklahoma Health Research Program: Biodegradable scaffolds for tissue regeneration, 2002 to 2005.

Publications

  • Lawrence BJ, Devarapalli M, Madihally SV (Feb 2009) Flow dynamics in bioreactors containing tissue engineering scaffolds., Biotechnology and bioengineering, 102 (3), 935-47 Abstract
  • Golla S, Madihally S, Robinson RL, Gasem KA (Feb 2009) Quantitative structure-property relationships modeling of skin irritation., Toxicology in vitro : an international journal published in association with BIBRA, 23 (1), 176-84 Abstract
  • Mirani RD, Pratt J, Iyer P, Madihally SV (Feb 2009) The stress relaxation characteristics of composite matrices etched to produce nanoscale surface features., Biomaterials, 30 (5), 703-10 Abstract
  • Rachakonda VK, Yerramsetty KM, Madihally SV, Robinson RL, Gasem KA (Nov 2008) Screening of chemical penetration enhancers for transdermal drug delivery using electrical resistance of skin., Pharmaceutical research, 25 (11), 2697-704 Abstract
  • Sarasam AR, Brown P, Khajotia SS, Dmytryk JJ, Madihally SV (Mar 2008) Antibacterial activity of chitosan-based matrices on oral pathogens., Journal of materials science. Materials in medicine, 19 (3), 1083-90 Abstract
  • Mondalek FG, Lawrence BJ, Kropp BP, Grady BP, Fung KM, Madihally SV, Lin HK (Mar 2008) The incorporation of poly(lactic-co-glycolic) acid nanoparticles into porcine small intestinal submucosa biomaterials., Biomaterials, 29 (9), 1159-66 Abstract
  • Lawrence BJ, Maase EL, Lin HK, Madihally SV (Mar 2008) Multilayer composite scaffolds with mechanical properties similar to small intestinal submucosa., Journal of biomedical materials research. Part A Abstract
  • Lawrence BJ, Madihally SV (2008) Cell Colonization in Degradable 3D Porous Matrices, Cell Adhesion and Migration, 2 (1), 1-8
  • Madihally SV, Lewis RS (2007) Implementation and analysis of hemodialysis in the Unit Operations Laboratory., Chemical Engineering Education., 41 (1), 67-71
  • Hooshmand S, Soung do Y, Lucas EA, Madihally SV, Levenson CW, Arjmandi BH (Sep 2007) Genistein reduces the production of proinflammatory molecules in human chondrocytes., The Journal of nutritional biochemistry, 18 (9), 609-14 Abstract
  • Sarasam AR, Samli AI, Hess L, Ihnat MA, Madihally SV (Sep 2007) Blending chitosan with polycaprolactone: porous scaffolds and toxicity., Macromolecular bioscience, 7 (9-10), 1160-7 Abstract
  • Lewis RS, Moshfeghian A, Madihally SV (2006) Engineering Analysis in Chem-E-Car Competition, Chemical Engineering Education, 40 (1), 66-72
  • Tillman J, Ullm A, Madihally SV (Nov 2006) Three-dimensional cell colonization in a sulfate rich environment., Biomaterials, 27 (32), 5618-26 Abstract
  • Moshfeghian A, Tillman J, Madihally SV (Nov 2006) Characterization of emulsified chitosan-PLGA matrices formed using controlled-rate freezing and lyophilization technique., Journal of biomedical materials research. Part A, 79 (2), 418-30 Abstract
  • Madihally SV, Maase E (2006) Biomedical and Biochemical Engineering for K-12 students, Chemical Engineering Education, 40 (4), 283-90
  • Madihally SV, Pantelogianis A, Toner M (Sep 2006) Antiproteolytic action of orally delivered insulin using pH-responsive hydrogels in a rat burn model., The Journal of surgical research, 135 (1), 187-94 Abstract
  • Sarasam AR, Krishnaswamy RK, Madihally SV (Apr 2006) Blending chitosan with polycaprolactone: effects on physicochemical and antibacterial properties., Biomacromolecules, 7 (4), 1131-8 Abstract
  • Huang Y, Siewe M, Madihally SV (Jan 2006) Effect of spatial architecture on cellular colonization., Biotechnology and bioengineering, 93 (1), 64-75 Abstract
  • Madihally SV (2006) Molecular Bioengineering, Encyclopedia of Chemical Processing, Sunggyu Lee, ed.,, New York, NY, Marcel Dekker, Inc,, 1709-16 pages (bookchapter)
  • Madihally SV, Maase EL (2006) Introducing Biomedical and Biochemical Engineering for K-12 students, Proceedings of the ASEE Annual Conference and Exposition., Chicago, IL
  • Huang Y, Onyeri S, Siewe M, Moshfeghian A, Madihally SV (Dec 2005) In vitro characterization of chitosan-gelatin scaffolds for tissue engineering., Biomaterials, 26 (36), 7616-27 Abstract
  • Sarasam A, Madihally SV (Sep 2005) Characterization of chitosan-polycaprolactone blends for tissue engineering applications., Biomaterials, 26 (27), 5500-8 Abstract
  • Raghavan D, Kropp BP, Lin HK, Zhang Y, Cowan R, Madihally SV (Apr 2005) Physical characteristics of small intestinal submucosa scaffolds are location-dependent., Journal of Biomedical Materials Research. Part a, 73A (1), 90-6 Abstract
  • Cutbirth D, Hughes B, Madihally SV (2005) Introducing Biomedical Engineering Using Creatinine Based Time-in-Dialysis Experiment, Proceedings of the ASEE Annual Conference and Exposition., Portland, OR
  • Bunnell Z, Scott G, Madihally SV (2004) Integrating Process Simulation into the Unit Operations Laboratory Through an Absorption Column Experiment, Proceedings of the ASEE Annual Conference and Exposition., Salt Lake City, UT, 6 pages
  • Lawrence B, Beene J, Madihally SV, Lewis RS, Incorporation of Non-ideal Reactors in a Junior-level Course Using Computational Fluid Dynamics, Chemical Engineering Education, 38(2), 136-141, 2004
  • Fish WW, Madihally SV (May-Jun 2004) Modeling the inhibitor activity and relative binding affinities in enzyme-inhibitor-protein systems: application to developmental regulation in a PG-PGIP system., Biotechnology Progress, 20 (3), 721-7 Abstract
  • Lawrence B, Madihally SV, Rhinehart RR (2003) A Novel Unit Operations' Project to Reinforce the Concepts of Reactor Design and Transport Phenomena, Proceedings of the ASEE Annual Conference and Exposition., Nashville, TN, 5 pages
  • Madibally SV, Solomon V, Mitchell RN, Van De Water L, Yarmush ML, Toner M (Feb 2003) Influence of insulin therapy on burn wound healing in rats., The Journal of Surgical Research, 109 (2), 92-100 Abstract
  • Madihally SV, Toner M, Yarmush ML, Mitchell RN (Nov 2002) Interferon gamma modulates trauma-induced muscle wasting and immune dysfunction., Annals of Surgery, 236 (5), 649-57 Abstract
  • Solomon V, Madihally S, Mitchell RN, Yarmush M, Toner M (Jun 2002) Antiproteolytic action of insulin in burn-injured rats., The Journal of Surgical Research, 105 (2), 234-42 Abstract
  • Madihally SV, Toner M, Yarmush ML, Mitchell RN (Mar 2001) Peripheral blood mononuclear cells exhibit hypercatabolic activity in response to thermal injury correlating with diminished MHC I expression., The Journal of Trauma, 50 (3), 500-9 Abstract
  • Chupa JM, Foster AM, Sumner SR, Madihally SV, Matthew HW (Nov 2000) Vascular cell responses to polysaccharide materials: in vitro and in vivo evaluations., Biomaterials, 21 (22), 2315-22 Abstract
  • Solomon V, Madihally S, Yarmush M, Toner M (Sep 2000) Insulin suppresses the increased activities of lysosomal cathepsins and ubiquitin conjugation system in burn-injured rats., The Journal of Surgical Research, 93 (1), 120-6 Abstract
  • Madihally SV, Matthew HW (Jun 1999) Porous chitosan scaffolds for tissue engineering., Biomaterials, 20 (12), 1133-42 Abstract
  • Madihally SV, Flake AW, Matthew HW (1999) Maintenance of CD34 expression during proliferation of CD34+ cord blood cells on glycosaminoglycan surfaces., Stem Cells (dayton, Ohio), 17 (5), 295-305 Abstract

Profile Details

Last Updated: 1/14/2009

COS Expertise ID #1096569
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