Dr. Hollie I. Swanson

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University of Kentucky
College of Medicine
Basic Science: Molecular and Biomedical Pharmacology
Associate ProfessorAppointed: 2001
University of Kentucky
College of Medicine
Graduate Center for Toxicology
Assistant Professor, Joint AppointmentAppointed: 1996
Professional Headshot of Hollie I. Swanson

Mailing Address

Department of Pharmacology
College of Medicine
University of Kentucky
MN 322
Lexington, Kentucky 40536-0084
United States

Contact Information

Phone: (859) 323-1463
Fax: (859) 323-1981
hswan@uky.edu

Qualifications

Ph.D., Purdue University, Food Science/Toxicology, 1991.
M.S., Oregon State University, Food Science/Toxicology, 1988.
B.S., South Dakota State University, Chemistry, 1985.

Expertise and Research Interests

Our laboratory is focused on study of the aryl hydrocarbon receptor (AHR) signaling pathway and its role in altering cell fate. The AHR is a basic helix-loop-helix transcription factor that binds toxic compounds such as dioxins. These compounds are pervasive environmental contaminants that are formed during combustion reactions and certain manufacturing processes. While the endogenous ligand for the AHR is not known, the best known AHR agonist is dioxin. One of the long-term goals of our research program is determining the mechanisms by which dioxin, via activation of the AHR, results in tumor promotion. Known genes that are regulated by the AHR include cytochrome P4501A1, however, we are also identifying novel, AHR regulated genes. To understand what genes the AHR regulates under normal conditions and how these genes are altered during dioxin-induced tumor promotion we are using cultured human keratinocytes and keratinocytes obtained from mice that lack the AHR. We have recently discovered that dioxin, via the AHR, downregulates major regulators of the senescence pathway, p53 and p16INK4a, block senescence and extends the lifespan of these cells. A second project focuses on determining the role of the AHR in protecting the cell from apoptosis.

Our laboratory uses a number of molecular techniques such as gel shift assays, transient transfections, RNase protection assays, real time RT-PCR, DNA microarray analysis and chromatin immunoprecipitation assays to address these research questions.

Other Expertise

Grant Reviewer (NIEHS, regular member and National Science Foundation, ad hoc)
Editorial Board (Toxicology and Applied Pharmacology 2002-2005)
Invited Chairperson (Gordon Conference; Society of Toxicology National Meeting)
Invited Presenter for Workshops(National Society of Toxicology)
Manuscript Referee (Multiple Listings)
Department of Pharmacology Graduate Studies Committee, 1996-present.
College of Medicine Scholarship Committee, 1996-1999.
College of Medicine Research Committee, 1997-2002. (Chair 1999-2002)
Department of Physiology Review Committee, 1999.
Department of Pharmacology Faculty Search Committee, 1998, 1999, 2000, 2002, 2005..
Department of Physiology Chair Search Committee, 2001-2002
Department of Pharmacology Internal Departmental Review Committee-CoChair, 2002
University of Kentucky Graduate Dean Search Committee, 2003
University of Kentucky Cancer Center Faculty Search Committee, 2003-2005.
Department of Pharmacology Seminar Director, 2001-2005.
College of Medicine Dean's Advisory Group, 2005-present.
University of Kentucky University Senate, 2006-2009
University of Kentucky Senate Advisory Committee on Privilege and Tenure, 2006-2009.
College of Medicine, Department of Radiology Chair Search Committee, 2007-

Keywords

COS Keywords:

Apoptosis, Biochemistry, Gene Regulation, Pharmacology, Toxicology, Transcription, Tumors.

Additional Terms:

Basic Helix Loop Helix, Dioxin, Gene Regulation, Receptor, Transcription Factor.

Memberships

Advisory Board: 02-05 Florida A & M University ARCH Program, 02-05 Kentucky EPA EPSCoR Committee
Advisory Board: 06-07 Institute of Medicine of the National Academies, Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides
American Association for Cancer Research
American Association of Medical Colleges
American Society for Pharmacology and Experimental Therapeutics
Circle of Powers Leadership Development
College of Medicine Dean's Advisory Group
College of Medicine Research Committee
College of Medicine Scholarship Committee
College of Medicine, Department of Radiology Chair Search Committee
Dean's Mentored Leadership Development
Department of Pharmacology Faculty Search Committee
Department of Pharmacology Graduate Studies Committee
Department of Pharmacology Internal Departmental Review Committee
Department of Physiology Chair Search Committee
Department of Physiology Review Committee
Environmental Health Perspectives
Gamma Sigma Delta
K-12 Outreach Subcommittee of the Society of Toxicology National Organization
Lexington Children's Museum
Medical Center Grant, University of Kentucky
Outreach Program for Minority Students
Pastoral Call Committee, St. John's Lutheran Church
Sigma Xi, The Scientific Research Society
Society of Toxicology
Society of Toxicology National Meeting
St John's Lutheran Church
UK Superfund Basic Research Program Internal Advisory Board
University of Kentucky Cancer Center Faculty Search Committee
University of Kentucky Graduate Dean Search Committee
University of Kentucky Senate Advisory Committee on Privilege and Tenure
University of Kentucky University Senate

Honors and Awards

2003-2006, Wethington Research Award, University of Kentucky
1992-1995, National Research Service Award (NIH), NIEHS, Northwestern University
1991-1992, Environmental Toxicology Postdoctoral Training Fellowship (PHS), NIEHS, Michigan State University
1988-1990, David Ross Fellowship, Purdue University
1985-1985, Chlorox Scholarship,
1985-1986, Oregon State University Out-of State Honors Award, Oregon State University
1981, Scholarship, Chemistry Department, South Dakota State University
1981-1983, Scholarship, Music Department, South Dakota State University

Previous Positions

1995-2001, Assistant Professor, University of Kentucky, College of Medicine, Pharmacology
1992-1995, Postdoctoral Fellow, Northwestern University, Dental School, Molecular Pharmacology and Biological Chemistry
1991-1992, Postdoctoral Fellow, Michigan State University, Basic Science: Biochemistry
1990-1990, Graduate Teaching Assistant, Purdue University, Food Science Laboratory
1985-1988, Graduate Teaching Assistant, Oregon State University, Food Chemistry and Carbohydrate Laboratory

Patents

Development of AHR-PROTACS as Antagonists of the Aryl Hydrocarbon Receptor, Patent Number: , 2007, United States of America.

Funding Received

  • American Lung Association (ALA): The aryl hydrocarbon receptor and lung cancer, $25,000, Jul 1, 1999 to Jun 30, 2000.
  • National Institutes of Health (NIH): NIEHS Environmental Toxicology Training Grant, Jul 1, 1990 to Jun 30, 2005.
  • National Institutes of Health (NIH): The Aryl Hydrocarbon Receptor and Differentiation, $200,000, Dec 1, 2001 to Nov 30, 2006.
  • National Institutes of Health (NIH): Convergence of TCDD gene activation with other pathways, $200,000, Apr 1, 2002 to Mar 31, 2007.
  • : Multiuser Affymetrix Gene Chip System, $338,650, Apr 1, 2001 to Mar 31, 2002.
  • American Institute for Cancer Research: Apigenin and Kaempferol as dietary chemopreventive agents in oral cancers, $75,000, 2007 to 2009.
  • National Institutes of Health (NIH): AHR-Protac, a novel AHR antagonist, $950,000, 2006 to 2011.
  • 1 R41 CA115093-01 (Littleton): Novel estrogen receptor ligands from plant genomics, $100,000, 2006 to 2007.
  • National Institutes of Health (NIH): Chemopreventative properties of aryl hydrocarbon receptor antagonists, $145,963, 2006 to 2008.
  • University of Kentucky Medical Center Research Fund Grant: Role of the Ah Receptor Nuclear Translocator in c-myc Regulation of p53 and Apoptosis, $13,000, 1996 to 1997.
  • University of Kentucky Medical Center Research Fund Grant: Elucidation of ARNT as a Transcriptional Regulator, $15,000, 1995 to 1996.
  • American Cancer Society (ACS): Potential Convergence of AH receptor/ARNT and myc/max Signaling Pathways, $11,000, 1995 to 1996.

Publications

  • Wu, R., Hoagland, M.S. and Swanson, H.I., Lack of the AHR leads to impaired activation of AKT/PKB and enhanced sensitivity to UV-induced apoptosis in murine hepatoma cells, J Pharmacol Exp Ther, 320, 448-47, 2007
  • Wu, R, Swanson, H.I, Aryl hydrocarbon receptor antagonists increase UV-induced apoptosis in human oral keratinocytes, The Toxicologist, S-1, #1415., 2007
  • Puppala, D, Lee, H, Kim, K, Swanson, H.I, Development of an AHR antagonist using PROTACS approach: A potencial approach for chemoprevention, The Toxicologist, S-1 #1413, 2007
  • Puppala, D, Lee, H, Kim, K.B, Swanson, H.I, Degradation of AHR by PROTACS: A novel approach for cancer chemoprevention, Proceedings of American Association for Cancer Research, # 321., 2007
  • Zhang, L, Valentino, J., Dingle, R., Xu, P., Vongrises, D.and Swanson, The effect of cigarette smoke consitutents on AHR signaling and senescence in nomal human oral keratinocytes, The Toxicologist, 90(S-1), 210, 2006
  • Puppala, D. and Swanson, H.I., Inhibition of the aryl hydrocarbon receptor signaling pathway and cigarette smoke induced cell transformation by select dietary flavonoids, 2006 Experimental Biology meeting abstracts [on CD-ROM]. The FASEB Journal, Abstract #176.2, 20, 2006
  • Wu, R. and Swanson, H.I., Lack of the AHR leads to impaired activation of Akt/PKB and enhanced sensitivity to UV-induced apoptosis in murine hepatoma cells, 2006 Experimental Biology meeting abstracts [on CD-ROM]. The FASEB Journal, Abstract #176.3, 20, 2006
  • Swanson, HI and Perman, J.A., A Model for Implementing a Dean-Mentored, Individual Leadership Development Program within an Academic Health Center, American Association of Medical Colleges, IME #326, 2006
  • Swanson, H (2006) AHR-Protac, Development of a novel aryl hydrocarbon receptor antagonist, Seminar, Department of Biochemistry, University of Louisville
  • Swanson, H (2006) Regulation of keratinocyte senescence by the aryl hydrocarbon receptor, University of Kentucky Aging Center
  • Wu, R, Hoagland, M.S. and Swanson, H.I., ARNT, A putative coactivator of c-myc/max signaling pathway interacts with c-myc, The Toxicologist, 81(S-1), 1805, 2005
  • Puppala, D. and Swanson, H.I., Naturally occurring antagonists of the AHR pathway: A novel approach of cancer prevention?, The Toxicologist, 84(S-1), 85, 2005
  • Zhang, L., Dingle, R.W.C., Xu, P. and Swanson, H.I., TCDD suppresses the expression of CYP4B1, Proceedings of the 14th International Conference on Cytochrome, P450, 2005
  • Wache, S.C., Hoagland, E.M., Zeigler, G. and Swanson, H.I., Role of arginine residues 14 and 15 in dictating DNA binding stability and transactivation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator heterodimer, Gene Expression, 12, 231-243, 2005
  • Hoagland, M. S., Hoagland, E.M. and Swanson, H.I., The p53 inhibitor pifithrin alpha is a potent agonist of the aryl hydrocarbon receptor, J Pharmacol Exp Ther., 314, 603-10, 2005
  • H.I. Swanson, S.D. Kraner, S.S. Ray, M. Hoagland, E.D. Thompson, X. Zheng, Y. Tian (2005) Experimental approaches for the study of cytochrome P450 gene regulation, Drug Metabolism and Transport: Molecular Methods and Mechanisms, L. Lash, Eds., Humana Press. (bookchapter)
  • Swanson, H (2005) Delineating the role of the dioxin/aryl hydrocarbon receptor in immortalization, Seminar, Department of Pharmacology and Toxicology, Wright State University
  • Ray, S.S. and Swanson, H.I, Dioxin induced immortalization of normal human keratinocytes and silencing of p53 and p16Ink4a, Journal of Biological Chemistry, 279(26), 27187, 24 Jun 2004
  • Ray, S.S. and Swanson H.I., Activation of aryl hydrocarbon receptor by TCDD induces gene silencing by promoter methylation: A novel mechanism for TCDD mediated tumor promotion, The Toxicologist, 78, 1411, 2004
  • Hoagland, M.S., Hoagland, E.M., Ziegler, G.M. and Swanson, H.I., Pifithrin- is a potent aryl hydrocarbon receptor agonist, The Toxicologist, 78, 676, 2004
  • Swanson, H.I., Cytochrome P450 expression in human keratinocytes: An aryl hydrocarbon receptor perspective, Chem-Biol. Interactions 149, 69-79., 2004
  • Swanson, H. (2004) Regulation of the Aryl Hydrocarbon Receptor Pathway in Keratinocytes, National Society of Toxicology
  • Swanson, H. (2004) Mechanisms by which Dioxin Immortalizes Human Keratiocytes, The George Bailey Symposium
  • Swanson, H (2004) Tools for Functional Genomics, National Society of Toxicology, Continuing Education Program, Annual Meeting
  • Swanson, H (2004) Regulation of the Aryl Hydrocarbon Receptor Pathway in Keratinocytes, National Society of Toxicology
  • Swanson, H (2004) Mechanisms by which Dioxin Immortalizes Human Keratiocytes, The George Bailey Symposium
  • Swanson, H (2004) Delineating the role of the dioxin/aryl hydrocarbon receptor in human cancers, Seminar, Department of Biochemistry/Chemistry, South Dakota State University
  • Ray SS, Swanson HI, Alteration of keratinocyte differentiation and senescence by the tumor promoter dioxin, Toxicology and Applied Pharmacology, 192(2), 131-45, 2003 Abstract
  • Zhang, J., Ray, S. and Swanson, TCDD induces increased expression of retinoic acid metabolizing genes: possible role in altering proliferation and differentiation in human keratinocytes, The Toxicologist, 72, 1789, 2003
  • Ray, S.S. and Swanson, H.I., Elucidation of dioxin's tumor promoting activites: Use of microarray analysis to identify genes targeted during keratinocyte differentiation and senescence, Proceedings of American Association for Cancer Research, #6019, 2003
  • Swanson HI, DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation, Chemico-biological Interactions, 141(1-2), 63-76, September 2002 Abstract
  • Swanson HI, Whitelaw ML, Petrulis JR, Perdew GH, Use of [125I]4'-iodoflavone as a tool to characterize ligand-dependent differences in Ah receptor behavior, Journal of Biochemical and Molecular Toxicology, 16(6), 298-310, 2002 Abstract
  • Ray, S. and Swanson, H.I., Dioxin alters proliferation, differentiation and senescence in keratinocytes, The Toxicologist, This poster was also presented at the Ohio Valley Society of Toxicology, Nov. 15 and received 2nd pr, 66, 1255, 2002
  • Hoagland, M. S. and Swanson, H.I., Novel mechanism of AhR-mediated TCDD toxicity: Sequestration of ARNT from an endogenous role in p53 gene induction, The Toxicologist, 66, 1263, 2002
  • Swanson, H (2002) Alteration of apoptosis, differentiation and senescence by dioxin in keratinocytes, Seminar, Department of Environmental Medicine and Dentistry, University of Rochester
  • Heid SE, Walker MK, Swanson HI, Correlation of cardiotoxicity mediated by halogenated aromatic hydrocarbons to aryl hydrocarbon receptor activation, Toxicological Sciences, 61(1), 187-96, May 2001 Abstract
  • Swanson, H.I. , Harthun, E.M., Gursahani, H. and Hadley, R.W., Increased differentiation status and intracellular calcium levels in keratinocytes enhance the aryl hydrocarbon receptor signaling pathway, The Toxicologist, 60, 32, 2001
  • Thackberry, E.A., Swanson, H.I., Smith, S.M. and Walker, M.K., Cardiac hypertrophy and increased cardiac hypoxia signaling via hypoia inducible factor 1-alpha in mice lacking the aryl hydrocarbon receptor, The Toxicologist, 60, 170, 2001
  • Swanson, H (2001) Regulation of keratinocyte differentiation by dioxin and the aryl hydrocarbon receptor, Seminar, Institute of Chemical Toxicology, Wayne State University
  • Walker MK, Heid SE, Smith SM, Swanson HI, Molecular characterization and developmental expression of the aryl hydrocarbon receptor from the chick embryo, Comparative Biochemistry and Physiology. Toxicology & Pharmacology: Cbp, 126(3), 305-19, July 2000
  • Wache, S. and Swanson, H.I., Arachidonic acid and TCDD alter HaCaT keratinocyte differentiation, Presented at the Gordon Research Conference, "Mechanisms of Toxicity", Jul 2000
  • Heid SE, Pollenz RS, Swanson HI, Role of heat shock protein 90 dissociation in mediating agonist-induced activation of the aryl hydrocarbon receptor, Molecular Pharmacology, 57(1), 82-92, Jan 2000 Abstract
  • Klinge CM, Kaur K, Swanson HI, The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1, Archives of Biochemistry and Biophysics, 373(1), 163-74, 2000 Abstract
  • Heid, S.E., Walker, M.K. and Swanson, H.I., Agonist activation of the aryl hydrocarbon receptor compared to avian cardiotoxicity mediated by TCDD, The Toxicologist, 54, 1305, 2000
  • Walker, M.K., Heid, S.E., Smith, S.M. and Swanson, H.I., Developmental expression of the aryl hydrocarbon receptor (AHR) in the Avian embryo, The Toxicologist, 54, 641, 2000
  • Klinge CM, Bowers JL, Kulakosky PC, Kamboj KK, Swanson HI, The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements, Molecular and Cellular Endocrinology, 157(1-2), 105-19, 1999 Abstract
  • Heid, S.H. Pollenz, R.S. and Swanson, H.I., Molybdate inhibition of aryl hydrocarbon receptor activation, The Toxicologist, Presented at OV-SOT chapter, November 12, 1999 and received first prize, 38, 302, 12 Nov 1999
  • Swanson HI, Yang JH, Specificity of DNA binding of the c-Myc/Max and ARNT/ARNT dimers at the CACGTG recognition site, Nucleic Acids Research, 27(15), 3205-12, 1 Aug 1999
  • Wache, S.C. and Swanson, H.I., Effect of substitutions at residues 14/15 of the aryl hydrocarbon receptor (AHR) on cooperative binding to the dioxin response element (DRE), AACR Proceedings, 40, 4540, 1999
  • Heid, S.H., Walker, MK. and Swanson, H.I., Functional characterization of an avian aryl hydrocarbon receptor, ISSX Proceedings, 9th North American Meeting, 15, 492, 1999
  • Swanson, H (1999) DNA binding of the aryl hydrocarbon receptor and beyond, Seminar, Environmental Protection Agency, Cincinnati, OH
  • Swanson, H (1999) Mechanisms that govern the actions of the aryl hydrocarbon receptor, Seminar, College of Pharmacy, University of New Mexico Health Science Center
  • Swanson, H (1999) Mechanisms that govern the actions of the aryl hydrocarbon receptor, Department of Physiology, University of Kentucky
  • Swanson HI, Yang JH, The aryl hydrocarbon receptor interacts with transcription factor IIB, Molecular Pharmacology, 54(4), 671-7, October 1998 Abstract
  • Swanson, H.I. and Yang, J., Specificity of DNA binding of the c-myc/max and Arnt/Arnt dimers at the CACGTG recognition site, Presented at the Gordon Research Conference "Mechanisms of Toxicity", Jul 1998
  • Swanson, H.I. and Yang, J., The aryl hydrocarbon receptor interacts with transcription factor IIB, The Toxicologist, 42, 1767, 1998
  • Swanson, H (1998) Methods for Protein/Protein Interactions, National Society of Toxicology, Continuing Education Program, Annual Meeting
  • Swanson, H (1998) DNA binding of the basic helix loop helix/PAS proteins, Seminar, Department of Biochemistry, Oregon State Health Sciences University
  • Swanson, H.I. and Yang, J., The Aryl Hydrocarbon Receptor Interacts with Transcription Factor IIB, Presented at the American Association for Cancer Research, Oct 1997
  • Swanson, H.I. and Yang, J., Mapping the protein/DNA contact sites of the Ah receptor and Ah receptor nuclear translocator, The Toxicologist, 36, 1226, 1997
  • Swanson, H. (1997) DNA binding by the Ah receptor and ARNT-Additional Actors Required, Cytochrome P-450 Midwest Symposium
  • Swanson, H (1997) Gene Regulation by the Ah receptor and ARNT, Seminar, Department of Biochemistry, University of Louisville
  • Swanson, H (1997) DNA binding by the Ah receptor and ARNT-Additional Actors Required, Cytochrome P-450 Midwest Symposium, Purdue University
  • Swanson, H (1997) Gene Regulation by the Ah receptor and ARNT, Seminar, Department of Pharmacology, University of Cincinnati
  • Swanson, H (1997) Gene regulation of the Ah receptor and ARNT, Department of Surgery, University of Kentucky
  • Swanson HI, Yang Jh, Mapping the protein/DNA contact sites of the Ah receptor and Ah receptor nuclear translocator, Journal of Biological Chemistry, 271(49), 31657-65, 1996 Abstract
  • Swanson, H (1996) Gene Regulation by the AH receptor and ARNT, National Society of Toxicology, Continuing Education Program, Annual Meeting
  • Swanson, H (1996) Gene regulation of the Ah receptor and ARNT, Toxicology Program, University of Kentucky
  • Swanson HI, Chan WK, Bradfield CA, DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins, Journal of Biological Chemistry, 270(44), 26292-302, 1995 Abstract
  • Bank PA, Yao EF, Swanson HI, Tullis K, Denison MS, DNA binding of the transformed guinea pig hepatic Ah receptor complex: Identification and partial characterization of two high-affinity DNA-binding forms, Archives of Biochemistry and Biophysics, 317(2), 439-48, 1995
  • Tullis, K., Denison, M.S. and Swanson, H.I., Identification and characterization of multiple DNA binding forms of the Ah receptor complex from different species, In Organohalogen Compounds. Birnbaum, L., Clement, R., Fingerhut, M., Matsumura, F., Rammamoorthy, S., Robertson, L., and Safe, F. eds., 25, 399-402, 1995
  • Swanson, H.I. and Bradfield, C.A., Specificity of DNA Binding by the Ah Receptor, ARNT and SIM, The Toxicologist, 15, 488, 1995
  • Tullis, K., Swanson, H.I. and Denison, M.S., Characterization of the DNA Binding of TCDD: Ah Receptor Complexes Transformed In Vivo and In Vitro, The Toxicologist, 15, 1275, 1995
  • Swanson, H. (1995) DNA binding of the Ah receptor and ARNT, Cytochrome P-450 Midwest Symposium
  • Swanson, H (1995) Methods for the Analysis of DNA/Protein Interactions, National Society of Toxicology, Continuing Education Program, Annual Meeting
  • Swanson, H (1995) DNA binding of the Ah receptor and ARNT, Cytochrome P-450 Midwest Symposium, Purdue University
  • Swanson, H (1995) DNA binding of the Ah receptor and ARNT, Department of Physiology, University of Kentucky
  • Dolwick, K., Schmidt, J.V., Swanson, H.I., Carver, L., and Bradfield, C.A., Molecular Characterization of the Ah-Receptor, The Toxicologist, 14, 234, 1994
  • Denison, M.S., Swanson, H.I., Bank, P.A., and Yao, E.F., Interaction of Transformed Ah Receptor Complex with a Dioxin-responsive Element and Modulation of Gene Expression, The Toxicologist, 14, 238, 1994
  • Tullis, K., Swanson, H.I., Bank, P.A. and Denison, M.S., Characterization of the Transformation and DNA binding of Transformed TCDD:Ah Receptor Complex from various Species and Tissues, The Toxicologist, 14, 1026, 1994
  • Schafer MW, Madhukar BV, Swanson HI, Tullis K, Denison MS, Protein kinase C is not involved in Ah receptor transformation and DNA binding, Archives of Biochemistry and Biophysics, 307(2), 267-71, December 1993 Abstract
  • Swanson HI, Tullis K, Denison MS, Binding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer: Evidence for two distinct heteromeric DNA-binding forms, Biochemistry, 32(47), 12841-9, 1993
  • Dolwick KM, Schmidt JV, Carver LA, Swanson HI, Bradfield CA, Cloning and expression of a human Ah receptor cDNA, Molecular Pharmacology, 44(5), 911-7, November 1993 Abstract
  • Swanson HI, Bradfield CA, The AH-receptor: Genetics, structure and function, Pharmacogenetics, 3(5), 213-30, October 1993
  • Dolwick KM, Swanson HI, Bradfield CA, In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition, Proceedings of the National Academy of Sciences (USA), 90(18), 8566-70, 1993 Abstract
  • Swanson HI, Perdew GH, Half-life of aryl hydrocarbon receptor in Hepa 1 cells: Evidence for ligand-dependent alterations in cytosolic receptor levels, Archives of Biochemistry and Biophysics, 302(1), 167-74, April 1993
  • Denison, M.S., Swanson, H.I., Madhukar, B.V. and Schafer, M.W., Protein Kinase C is not involved in Ah receptor transformation and DNA binding, Toxicologist, 13, 32, 1993
  • Swanson, H.I. and Denison, M.S., Binding of transformed Ah receptor complex to a dioxin responsive enhancer: Identification of two distinct heterodimeric DNA binding forms, Toxicologist, 13, 30, 1993
  • Dolwick, K., Schmidt, J.V., Swanson, H.I., Carver, L. and Bradfield, C.A., Molecular characterization of the Ah receptor, The Biochemical Society Meeting, 649, F2, 1993
  • Swanson HI, Perdew GH, Detection of the Ah receptor in rainbow trout: Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin in cell culture, Toxicology Letters, 58(1), 85-95, September 1991
  • Swanson, H.I. and Perdew, G.H., Determination of Ah receptor synthesis and turnover in Hepa 1 cells, Toxicologist, 11, 991, 1991
  • Fong AT, Swanson HI, Dashwood RH, Williams DE, Hendricks JD, Bailey GS, Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation, Biochemical Pharmacology, 39(1), 19-26, 1990 Abstract
  • Swanson, H. Fong, A., Dashwood, R., Williams, D., Hendricks, J. and Bailey, G, Mechanisms of anti-carcinogenesis by indole-3-carbinol: Studies of enzyme induction, electrophilic-scavenging, and competitive inhibition of aflatoxin B1 activations, Proceedings American Association of Cancer Research, 30, 700, 1989
  • Puppala, D., Gairola, C.G. and Swanson, H.I., Identification of kaempferol as an inhibitor of cigarette smoke induced activation of the aryl hydrocarbon receptor and cell transformation, Carcinogenesis, In Press
  • Zhang, L. Wu, R., Dingle, R.W.C., Gairola, C.G., Valentino, J. and Swanson, H.I., Cigarette smoke condensate and dioxin suppress culture shock induced senescence in normal human oral keratinocytes, Oral Oncology, In Press
  • Lee, H, Puppala, D, Swanson, H.I., Kim, K-B, Targeted Degradation of aryl hydrocarbon receptor (AHR) via the PROTAC approach: A chemical genetic tool for AHR biology (In preparation).
  • Puppala, D, Lee, H, Kim, K.B, Swanson, H.I, Development of an AHR antagonist using the PROTACS approach: A potential tool for chemoprevention (In preparation).

Profile Details

Last Updated: 7/26/2007

COS Expertise ID #456592
Reference this profile directly: http://myprofile.cos.com/swanson5547