Laura L. Symonds |
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Michigan State University College of Human Medicine Psychiatry Assistant ProfessorAppointed: 1997 Michigan State University Neuroscience Program Faculty MemberAppointed: 1997 Michigan State University Cognitive Science Program Faculty MemberAppointed: 1997 Michigan State University Radiology |  |
Mailing AddressDepartment of Radiology 184 Radiology Building Service Road Michigan State University East Lansing, Michigan 48824United States | Contact Information |
Qualifications
Ph.D., University of Pennsylvania, Anatomy/Neurobiology, 1982.
B.S., Vanderbilt University, Psychology, 1974.
Expertise and Research Interests
Research Interests:
My research is directed toward identifying and understanding the neural circuits that underlie cognitive behaviors, specifically those that go awry in psychosis and with age. I have used neuropsychological investigations, structural neuroimaging, and more recently functional neuroimaging, to address questions such as: Which cognitive abilities are relatively spared in aging adults, and what predicts such successful neurocognitive aging? Which areas of the brain are smaller (or larger) in schizophrenia patients? Is white matter pathology that is seen in magnetic resonance imaging a pathological feature of aging, and is it increased in the brains of psychosis patients?
I am now beginning a research program that targets 3 main areas of study:
1. Functional thalamo-cortical circuits in schizophrenia (using neuropsychological testing and functional MRI);
2. Representation of acute pain in chronic pain patients (using functional MRI);
3. Successful neurocognitive aging (using neuropsychological testing, structural MRI, functional MRI).
My research is directed toward identifying and understanding the neural circuits that underlie cognitive behaviors, specifically those that go awry in psychosis and with age. I have used neuropsychological investigations, structural neuroimaging, and more recently functional neuroimaging, to address questions such as: Which cognitive abilities are relatively spared in aging adults, and what predicts such successful neurocognitive aging? Which areas of the brain are smaller (or larger) in schizophrenia patients? Is white matter pathology that is seen in magnetic resonance imaging a pathological feature of aging, and is it increased in the brains of psychosis patients?
I am now beginning a research program that targets 3 main areas of study:
1. Functional thalamo-cortical circuits in schizophrenia (using neuropsychological testing and functional MRI);
2. Representation of acute pain in chronic pain patients (using functional MRI);
3. Successful neurocognitive aging (using neuropsychological testing, structural MRI, functional MRI).
Keywords
COS Keywords:
Anatomy, Chronic Pain, Cognitive Science, Magnetic Resonance Imaging, Neurobiology, Neuropsychology, Neuroscience, Psychosis, Radiology, Schizophrenia.Memberships
American Pain Society
Cognitive Neuroscience Society
International Neuropsychology Society (INS)
International Society for Neuroimaging in Psychiatry
International Society for the Study of Pain
Pfizer Pain Neuroimaging Research Group Advisory Board
Society for Neuroscience
Honors and Awards
1974, Graduated Cum Laude,
Vanderbilt University,
Psychology
Previous Positions
1996-1997, Research Assistant Professor,
University of California, San Diego,
School of Medicine,
Psychiatry
1994-1996, Research Fellow,
University of California, San Diego,
VA Medical Center,
Geriatric Psychiatry
1992-1994, Neuropsychology Associate,
Neurobehavioral Associates,
East Lansing
1992-1994, Director,
Psychological Associates in Rehabilitation,
East Lansing,
Clinical Rehabilitation
1990-1992, Neuropsychology Associate,
Tamarack and Grand River Psychological Services,
East Lansing
1990-1992, Director,
Tamarack and Grand River Psychological Services,
East Lansing,
Neuropsychology Research
1989-1990, Assistant Professor,
Michigan State University,
College of Natural Science,
Zoology
1987-1989, Adjunct Assistant Professor,
Michigan State University,
College of Natural Science,
Zoology
1985-1987, Fellow,
Oxford University,
Corpus Christi College
1985-1987, College Tutor,
Oxford University,
Corpus Christi College
1985-1987, Postdoctoral Fellow,
Oxford University,
Human Anatomy
1982-1985, Postdoctoral Fellow,
Princeton University,
Biology
1977-1982, Graduate Student,
University of Pennsylvania,
School of Medicine,
Anatomy
1975-1977, Research Assistant,
Vanderbilt University,
College of Arts and Science,
Psychology
1974-1975, Medical Social Work Assistant,
Vanderbilt University,
Medical School
Funding Received
- NIH/NICHD: In-utero Exposures and Childhoood Developmental Problems, $8,000,000, Pending to .
- Univesity of California San Diego: Geriatric Psychiatry Clinical Research Center Pilot Grant Program, Oct 1996 to Sep 1997.
- NIH/NIMH: Depression and Altered Pain Perception, $298,500, May 2003 to Mar 2005.
- Michigan State University: Intramural Research Grant Program, May 1999 to Sep 2001.
- National Alliance for Research on Schizophrenia and Depression (NARSAD): The Thalamus in Schizophrenia: Contribution of the Individual Nuclei to Clinical Symptoms and Cognitive Impairment, $30,000, Jul 1, 1996 to Jun 30, 1999.
- Michigan State University: Life Sciences Research Incubator Award, $65,178, Dec 2003 to Jun 2005.
- Scottish Rite Schizophrenia Research Program: The Thalamus in Schizophrenia: Contribution of the Individual Nuclei to Clinical symptoms and Cognitive Impairment. A structural MRI Study, $22,608, Aug 1, 1996 to May 1, 1999.
- NIH Biomedical Research Support Grant: , 1988 to .
- Herbert von Karajan Neuroscience Research Trust Scholarship: , 1987 to .
- NIH National Research Service Award: , 1983 to 1985.
- March of Dimes Birth Defects Foundation Basic Research grant: , 1982 to 1983.
- NIH Training Grant: Predoctoral award, 1977 to 1982.
Publications
- Bixby JC, Gordon NS, Hill MM, Ludwig B, Goodman J, Bates D, Symonds LL, Is Pain Processing Lateralized to One Hemisphere in the Abscence of Explicitly Directing Attention to the Pain?, Abstract in the Journal of Cognitive Neuroscience, 2003
- Rogaski EJ, Symonds LL, Bixby JC, Sudheimer KD, WHalen S, Potchen EF, Cortical Activation during sad mood induction: An fMRI study, Society of Neuroscience Abstract, 28, 2002
- Symonds LL, Bixby, Potchen MJ, Cooper TG, Pothen EJ, Cortical areas that potentially code pain intensity information: An fMRI study, Abstract in Neuroimage, 13, 946, 2001
- Sudheimer KD, Davis KK, Bixby JC, Knox D, Symonds LL, An emotion induction paradigm for neuroimaging: International Affective Picture System (IAPS), Society of Neuroscience Abstract, 27, 2001
- Symonds LL, Jeste DV, Late-onset schizophrenia, Late-Onset Mental Disorders, 83-97, 1999
- Symonds LL, Archibald SL, Grant I, Zisook S, Jernigan TL, Does an increase in sulcal or ventricular fluid predict wher brain tissue is lost?, Journal of Neuroimaging, 9, 201-209, 1999
- Goran DA, Bernard RA, Cooper TG, Potchen MJ, SMonds LL, fMRI demonstration of somatotopic organizaiton of pain in somatosensory cortex, Abstract in Neuroimage, 9, 822, 1999
- Symonds LL, Potchen MJ, Goren DA, COoper TG, Potchen EJ, Activation of cortical areas in response to acute pain: An fMRI study, Abstract in Neuroimage, 9, 826, 1999
- Jeste DV, McAdams LA, Palmer BW, Braff D, Jernigan TL, Stout J, Paulsen JS, Symonds LL, Bailey A, Heaton RK, Relationship of neuropsychological and MRI measures to age of onset of schizophrenia, Acta Psychiatrica Scandinavica, 98, 156-164, 1998
- Symonds LL, Gladsjo JA, Heaton RK, Jeste DV, Patterns of successful neruocognitive aging, Abstract in the Journal of International Neuropsychology, 1998
- Symonds LL, Jeste DV, Neruoimaging in late-life psychosis, Brian Imaging in Clinical Psychiatry, 426-448, 1997
- Symonds LL, Olichney JM, Jernigan TL, Corey-Bloom J, Healy JF, Jeste DV, Lack of clinically significant structural abnormalities in MRIs of older patients with schizophrenia and related psychoses, Journal of Neuropsychiatry Clinical Neuroscience, 9, 251-258, 1997
- Jeste DV, Symonds LL, Non-dementia non-praecox dementia praecox?: Late-onset schizophrenia, American Journal of Geriatric Psychiatry, 5, 302-317, 1997
- Kinderman SS, Karimi A, Symonds LL, Brown GG, Jeste DV, Review of functional magnetic resonance imaging in schizophrenia, Schizophrenia Research, 27, 143-156, 1997
- Jeste DV, Symonds LL, Jernigan TL, Stout J, Braff D, Heaton RK, Thalamus and late-life schizophrenia, Abstract presented at the American Psychiatric Association Meeting, 1997
- Gatzke LM, Symonds LL, Jernigan TL, Jeste DV, White matter abnomalities in older schizophrenia patiencts compared to healthy volunteers, Society of Neuroscience Abstract, 23, part 1, 559, 1997
- Symonds LL, Jernigan TL, Jeste DV, Altered pattern of grey matter volumes in older schizophrenia pateints: A quantitative MRI study, Society of Neuroscience Abstract, 23, part 1, 560, 1997
- Strout JC, Symonds LL, Paulsen JS, Jernigan TL, Archibald SL, Harris MJ, Braff DI, Jeste DV, Brain morphometric correlates of age and age of onset in schizophrenia, Society of Neuroscience Abstract, 21, Part 1, 240, 1995
- Symonds LL, Lindamer L, Jernigan T, Heaton R, Paulsen J, Braff D, Zisook S, Kuck J, Jeste D, Neuroanatomical correlates (MRI) of CVLT measures in schizophrenia patients, Abstract in the Journal of International Neuropsychological Society, 1995
- Late-onset schizophrenia: Comprehensive study, Symposium Abstract for the American Psychiatic Association, 1995
- Guillery RW, Crabtree JW, Symonds LL, The beta sector of the rabbit's dorsal lateral geniculate nucleus: A comparison with the perigeniculate nucleus of the cat, Proc. Roy. Soc. Lond., B 233, 17-32, 1987
- Guillery RW, Crabtree JW, Symonds LL, The beta sector of the rabbit's dorsal lateral geniculate nucleus: A comparison with the cat's perigeniculate nucleus, Abstract in Neuroscience, 22 (suppl.), S415, 1987
- Symonds LL, Guillery RW, The organisational of retinal input to the ventral lateral geniculate nucleaus in cats, Abstract in Neuroscience, 22 (suppl.), S804, 1987
- Symonds Ll, Cooke IRC, Constantine-Paton M, Distribution of GABA-like immunoreactivity in the developing frog tectum, Abstract in Suppl. Invest. Ophthal. Vis. Sci., 26, 1985
- Symonds LL, Rosenquist AC, Cortico-cortical connections among visual areas in the cat, Journal of Comparative Neurology, 129, 1-38, 1984
- Symonds LL, Rosenquist AC, Laminar origins of visual cortico-cortical connections in the cat, Journal of Comparative Neurology, 129, 39-47, 1984
- Symonds LL, Rosenquist AC, The cortical laminae of origin of visual intracortical pathways in the cat, Abstract in Suppl. Invest. Ophthal. Vis. Sci., 24, 107, 1983
- Wall JT, Symonds LL, Kaas JH, Cortical and subcortical projections of the middle temporal area (MT) and adjacent cortex in galagos, Journal of Comparative Neurology, 211, 193-214, 1982
- Symonds LL, Rosenquist AC, Edwards SB, Palmer LA, Projections of the pulvinar-lateral posterior complex to visual cortical areas in the cat, Neuroscience, 6, 1995-2020, 1981
- Rosenquist AC, Raczkowski D, Symonds LL, The functional organization of the lateral posterior-pulvinar complex in the cat, Changing Concepts of the Nervous System. Proceedings of the First Institute of Neruological Sciences Symposium in Neurobiology, 1981
- Rosenquist A, Raczkowski D, Segraves M, Spring E, Symonds L, Electophysiological mapping and anatomical connectivity studies of cortical and subcortical visual areas in the cat, Abstract in Exp Brain Res., 41, A16-17, 1980
- Wall JT, Symonds LL, Kaas JH, Projection of middle temporal visual area (MT) in the prosimian Galago senegalenis, Abstract in Suppl. Invest. Ophthal. Vis. Sci., 1, 1980
- Symonds L, Rosenquist A, Visual cortical input to area 20 of the cat: Anatomical evidence for subdivision fo this region into two areas, Society of Neuroscience Abstract, 5, 809, 1979
- Symonds LL, Kaas JH, Connections of the striate cortex in the prosimian, Galago senegalensis, Journal of Comparative Neurology, 181, 477-512, 1978
- Symonds L, Rosenquist A, Edwards S, Palmer L, Thalamic projections to electrophysiologically defined visual areas in the cat, Society of Neuroscience Abstract, 4, 647, 1978
- Allen TW, Walker K, Symonds L, Marcel M, Intrasensory and intersensory perception of temporal sequences during infancy, Devel. Psych., 13, 225-229, 1977
- Symonds LL, Kaas JH, Connections of striate cortex in a prosimian primate, Abstract in Anat. Rec., 187, 725, 1977
- Symonds LL, Potchen MJ, Bixby J, Cooper TG, Potchen EF, Processing of intensity during acute pain: An fMRI study, Neuroreport, Submitted
- Symonds LL, Sudheimer K, Bixby J, An emotion induction paradigm for neuroimaging: International Affective Picture System (IAPS), Manuscript in Preparation
- Symonds LL, Rogalski EJ, Bixby JC, Susheimer KD, Whalen S, Potchen EJ, Cortical activation during sad mood induction: An fMRI study, Manuscript in Preparation
- Symonds LL, Allen R, Given C, Given B, The relationship between depression early in disease and severity of pain over the following year in newly-diagnosed cancer patients, Manuscript in Preparation
Profile Details
Last Updated: 9/10/2008
COS Expertise ID #450380
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