Dr. Robert J. Tempelman

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Michigan State University
College of Agriculture and Natural Resources
Animal Science
ProfessorAppointed: 2006
Michigan State University
College of Natural Science
Statistics & Probability
Adjunct ProfessorAppointed: 1998
Professional Headshot of Robert J. Tempelman

Mailing Address

Department of Animal Science
1205 Anthony Hall
Michigan State University
East Lansing, Michigan 48824-1225
United States

Contact Information

Phone: (517) 355-8445
Fax: (517) 353-1699
tempelma@msu.edu
http://www.msu.edu/user/tempelma/

Qualifications

Ph.D., University of Wisconsin-Madison, Dairy Science, 1993.
M.Sc., University of Guelph, Animal Science, 1989.
B.Sc., University of Guelph, Animal Science, 1986.

Expertise and Research Interests

Bayesian Inference in Genetics and Genomics
Quantitative Genetics
Mixed Model Inference

Other Expertise

Co-director of the Statistical Consulting Center (SCC) of the College of Agriculture and Natural Resources

Future Research

Dr. Tempelman's research program is centered around the development and application of hierarchical statistical models to inferential problems in animal breeding and genetics. Hierarchical Bayesian models are particularly useful for modeling multiple layers of variability and heterogeneity as characteristic of experimental and observational data. Our two broad areas of application are currently in (1) quantitative genetics and (2) functional genomics. Dr. Tempelman also collaborates extensively with many other researchers on campus, particularly in the application of mixed effects and/or Bayesian model analyses to experimental and observational data.

Industrial Relevance

genetic evaluation of livestock

Keywords

COS Keywords:

Animal Genetics or Breeding, Animal Science, Applied Statistics, Bioinformatics, Biometry, Biostatistics, Human Population and Genetics, Livestock, Quantitative Genetics.

Additional Terms:

Animal Breeding, Applied Statistics, Bayesian Inference, Bioinformatics, Quantitative Biology, Quantitative Genetics, Statistical Genomics, Statistical Modeling.

Memberships

American Society of Animal Science
International Biometric Society

Previous Positions

2000-2006, Associate Professor, Michigan State University, College of Agriculture & Natural Resources, Animal Science
1995-2000, Assistant Professor, Michigan State University, College of Agriculture & Natural Resources, Animal Science
1993-1995, Assistant Professor, Louisiana State University, College of Agriculture-Natural Resources, Experimental Statistics

Funding Received

  • Environmental Protection Agency (EPA): Safety assessment of dietary proteins, $447,774, 2006 to 2009.
  • United States Department of Agriculture (USDA): Identification, differential expression, and mapping of muscle genes in genetically selected turkeys, $890,000, 2005 to 2009.
  • USDA-Integrated Program: Integration of transcriptional profiles with genetic marker data for identifying genes controlling economically important traits in pigs, $1,000,000, 2004 to 2007.
  • USDA-NRIGRP: Gene expression profiling during porcine skeletal muscle development and growth using a cDNA microarray., $265,000, 2003 to 2006.
  • USDA-NRIGRP: Hippocampal glucocorticoids mediate behavioral responses to stress in piglets, $200,000, 2002 to 2004.
  • USDA-IFAFS: Functional genomics of well-being and milk quality in cattle., $2,818,000, 2001 to 2004.

Publications

  • Tempelman RJ (Jan 2009) Invited review: assessing experimental designs for research conducted on commercial dairies., Journal of dairy science, 92 (1), 1-15 Abstract
  • Cardoso FF, Rosa GJ, Steibel JP, Ernst CW, Bates RO, Tempelman RJ (Nov 2008) Selective transcriptional profiling and data analysis strategies for expression quantitative trait loci mapping in outbred F2 populations., Genetics, 180 (3), 1679-90 Abstract
  • Grant AC, Ortiz-Colón G, Doumit ME, Tempelman RJ, Buskirk DD (Oct 2008) Differentiation of bovine intramuscular and subcutaneous stromal-vascular cells exposed to dexamethasone and troglitazone., Journal of animal science, 86 (10), 2531-8 Abstract
  • Sporer KR, Xiao L, Tempelman RJ, Burton JL, Earley B, Crowe MA (Feb 2008) Transportation stress alters the circulating steroid environment and neutrophil gene expression in beef bulls., Veterinary immunology and immunopathology, 121 (3-4), 300-20 Abstract
  • Edwards DB, Ernst CW, Tempelman RJ, Rosa GJ, Raney NE, Hoge MD, Bates RO (Feb 2008) Quantitative trait loci mapping in an F2 Duroc x Pietrain resource population: I. Growth traits., Journal of animal science, 86 (2), 241-53 Abstract
  • Martínez-Montemayor MM, Hill GM, Raney NE, Rilington VD, Tempelman RJ, Link JE, Wilkinson CP, Ramos AM, Ernst CW (2008) Gene expression profiling in hepatic tissue of newly weaned pigs fed pharmacological zinc and phytase supplemented diets., BMC genomics, 9, 421 Abstract
  • Tempelman RJ (2008) Statistical analysis of efficient unbalanced factorial designs for two-color microarray experiments., International journal of plant genomics, 2008, 584360 Abstract
  • Almeida PE, Weber PS, Burton JL, Tempelman RJ, Steibel JP, Zanella AJ (Dec 2007) Gene expression profiling of peripheral mononuclear cells in lame dairy cows with foot lesions., Veterinary immunology and immunopathology, 120 (3-4), 234-45 Abstract
  • Cardoso FF, Rosa GJ, Tempelman RJ (Apr 2007) Accounting for outliers and heteroskedasticity in multibreed genetic evaluations of postweaning gain of Nelore-Hereford cattle., Journal of animal science, 85 (4), 909-18 Abstract
  • Jansen, J.,, Kirkwood, R.N., Zanella, A.J., Tempelman, R.J. (2007) Influence of gestation housing on sow behavior and fertility., Journal of Swine Health and Production, 15 (3), 132-136
  • Souza, A.S., Jansen, J., Tempelman, R.J., Zanella, A.J. (2006) A novel method for testing social recognition in young pigs and the modulating effects of relocation, Applied Animal Behavior, 99, 77-87
  • Edwards DB, Tempelman RJ, Bates RO (Feb 2006) Evaluation of Duroc- vs. Pietrain-sired pigs for growth and composition., Journal of animal science, 84 (2), 266-75 Abstract
  • Rozeboom DW, Shaw DT, Tempelman RJ, Miguel JC, Pettigrew JE, Connolly A (Nov 2005) Effects of mannan oligosaccharide and an antimicrobial product in nursery diets on performance of pigs reared on three different farms., Journal of animal science, 83 (11), 2637-44 Abstract
  • Wade J, Tang YP, Peabody C, Tempelman RJ (Aug 2005) Enhanced gene expression in the forebrain of hatchling and juvenile male zebra finches., Journal of neurobiology, 64 (2), 224-38 Abstract
  • Cardoso FF, Rosa GJ, Tempelman RJ (Aug 2005) Multiple-breed genetic inference using heavy-tailed structural models for heterogeneous residual variances., Journal of animal science, 83 (8), 1766-79 Abstract
  • Vadnais ML, Kirkwood RN, Tempelman RJ, Sprecher DJ, Chou K (Jun 2005) Effect of cooling and seminal plasma on the capacitation status of fresh boar sperm as determined using chlortetracycline assay., Animal reproduction science, 87 (1-2), 121-32 Abstract
  • Tempelman RJ (May 2005) Assessing statistical precision, power, and robustness of alternative experimental designs for two color microarray platforms based on mixed effects models., Veterinary immunology and immunopathology, 105 (3-4), 175-86 Abstract
  • Kizilkaya, K., Tempelman, R.J. (2005) A general approach to mixed effects modeling of residual variances in generalized linear mixed models, Genetics, Selection, Evolution, 37, 31-56
  • Rosa GJ, Steibel JP, Tempelman RJ (2005) Reassessing Design and Analysis of two-Colour Microarray Experiments Using Mixed Effects Models., Comparative and functional genomics, 6 (3), 123-31 Abstract
  • Martínez, M.M., Hill, G.M., Link, J.E., Raney, N.E., Tempelman, R.J. and Ernst, C.W., Pharmacological zinc and phytase supplementation enhance metallothionein mRNA abundance and protein concentration in newly weaned pigs, Journal of Nutrition, 134, 538-544, 2004
  • Tempelman, R.J., Experimental design and statistical methods for classical and bioequivalence hypothesis testing with an application to dairy nutrition studies, Journal of Animal Science, 82 (E. Suppl.), E162-E172, 2004
  • Cardoso, F.F., and R.J. Tempelman, Hierarchical Bayes multiple-breed inference with an application to genetic evaluation of a Nelore-Hereford population, Journal of Animal Science, 82, 1589-1601, 2004
  • Gibson, S., R.J. Tempelman, and R.N. Kirkwood, Effect of oxytocin supplemented intra-uterine insemination on sow fertility, Journal of Swine Health and Production, 12, 182-185., 2004
  • Wade, J., C. Peabody, P. Coussens, R.J. Tempelman, D. Clayton, L. Liu, A.P. Arnold, and R. Agate, A cDNA microarray from the telencephalon of juvenile male and female zebra finches, ournal of Neuroscience Methods, 138, 199-206, 2004
  • Cardoso, F.F., and R.J. Tempelman, Genetic evaluation of beef cattle accounting for uncertain paternity, Livestock Production Science, in press, 2004
  • Guan, X., B.J. Bequette, P.K. Ku, R.J. Tempelman and N.L. Trottier, Amino acid need for milk synthesis is defined by the maximal uptake of plasma amino acid by the porcine mammary glands, Journal of Nutrition, in press, 2004
  • Saama, P.M., J.B. Jacob, M.E. Kehrli, Jr., A.E. Freeman, S.C. Kelm, A.L. Kuck, R.J. Tempelman, J.L. Burton., Genetic variation in bovine mononuclear leukocyte responses to dexamethasone, Journal of Dairy Science, in press, 2004
  • Tempelman, R.J., Rosa, G.J.M. (2004) Empirical Bayes Approaches to Mixed Model Inference in Quantitative Genetics, Genetic Analysis of Complex Traits Using SAS, Cary, N.C., SAS Institute Inc., 149-178 pages (bookchapter)
  • Rosa, G.J.M., Tempelman, R.J. (2004) Bayesian Mapping Methodology, Genetic Analysis of Complex Traits Using SAS, Cary, N.C., SAS Institute, Inc., 225-250 pages (bookchapter)
  • Kizilkaya, K., P. Carnier, A. Albera, G. Bittante, and R.J. Tempelman, Cumulative t-link threshold models for the quantitative genetic analysis of calving ease scores, Genetics, Selection, Evolution, 35, 489-512, 2003
  • Cardoso, F.F., and R.J. Tempelman, Bayesian inference on genetic merit under uncertain paternity, Genetics, Selection, Evolution, 35, 469-487, 2003
  • Sindelar, J.J., Prochaska, F., Britt, J., Smith, G.L., Miller, R.K., Templeman, R., Osburn, W.N., Strategies to eliminate atypical flavors and aromas in sow loins. I. Optimization of sodium tripolyphosphate, sodium bicarbonate, and injection level, Meat Science, 65, 1211-1222, 2003
  • Suchyta, S.P., Sipkovsky S., Halgren, R.G., Tempelman, R.J., Saama, P.M., Kruska, R., Jeffers, A., McNulty, A., Bauman, D.E., Burton, J.L. Collier, R.J., Ferris, T.A., Lucy, M.C., McGuire, M.A., Medrano, J.F., Smith, T.P., Sonstegard, T.S., Spiers, D.E.,, Development and Testing of a High-Density cDNA Microarray Resource for Cattle, Physiological Genomics, 15, 158-164, 2003
  • Pagan, M., Davis, M.E., Stick, D.A., Simmen, R.C.M., Raney, N.E., Tempelman, R.J., and C.W. Ernst, Evaluation of serum insulin-like growth factor binding proteins (IGFBP) in Angus cattle divergently selected for serum IGF-I concentration, Domestic Animal Endocrinology, 25, 345-358, 2003
  • Suchyta, S.P., Sipkovsky S., Halgren, R.G., Kruska, R.,Elftman, M., Weber-Nielsen, M., Vandehaar, M.J., Xiao, L., Tempelman, R.J., and Coussens, P.M., Bovine Mammary Gene Expression Profiling Using A cDNA Microarray Enhanced For Mammary Specific Transcripts, Physiological Genomics, 16, 8-18, 2003
  • Kizilkaya, K., B.D. Banks, P. Carnier, A. Albera, G. Bittante, and R.J. Tempelman, Bayesian inference strategies for the prediction of genetic merit using threshold models with an application to calving ease scores in Italian Piemontese cattle, Journal of Animal Breeding and Genetics, 119, 209-220, 2002
  • Tempelman, R.J., P.M. Saama, A.E. Freeman, S.C. Kelm, A.L. Kuck, M.E. Kehrli, Jr., J.L. Burton, Genetic variation in bovine neutrophil sensitivity to glucocorticoid challenge, Acta Agriculturć Scandinavica Section A: Animal Science, 52, 189-202, 2002
  • Tjardes, K.E., D.D. Buskirk, M.S. Allen, R.J. Tempelman, L. D. Bourquin, and S.R. Rust., Neutral detergent fiber concentration in corn silage influences dry matter intake, diet digestibility, and performance of Angus and Holstein steers, Journal of Animal Science, 80, 841-846, 2002
  • Mitchell, R.R., S.D. Fitzgerald, R.J. Aulerich, R.J. Balander, D.C. Powell, R.J. Tempelman, R.L Stickle, W. Stevens, and S.J. Bursian, Health effects following chronic dosing with tungsten-iron and tungsten-polymer shot in adult game-farm mallards, Journal of Wildlife Diseases, 37, 451-458, 2001
  • Mitchell, R.R., S.D. Fitzgerald, R.J. Aulerich, R.J. Balander, D.C. Powell, R. J. Tempelman, C. Cray, W. Stevens, and S.J. Bursian., Hematological effects and metal residue concentrations following chronic dosing with tungsten-iron and tungsten-polymer shot in adult game-farm mallards, Journal of Wildlife Diseases, 37, 459-467, 2001
  • Mitchell, R.R., S.D. Fitzgerald, R.J. Aulerich, R.J. Balander, R. J. Tempelman, W. Stevens, and S.J. Bursian, Reproductive effects and duckling survivability following chronic dosing with tungsten-iron and tungsten-polymer shot in adult game-farm mallards, Journal of Wildlife Diseases, 37, 468-474, 2001
  • Perkins, K.H., M.J. VandeHaar, R.J. Tempelman, J.L. Burton, Negative energy balance does not decrease expression of leukocyte adhesion or antigen-presenting molecules in cattle, Journal of Dairy Science, 84, 421-428, 2001
  • Preisler, M.T., P. S. D. Weber, R. J. Tempelman, R. J. Erskine, H. Hunt, and J. L. Burton, Glucocorticoid receptor expression profiles in mononuclear leukocyte populations of periparturient dairy cattle, Journal of Dairy Science, 83, 38-47, 2000
  • Preisler, M.T., P. S. D. Weber, R. J. Tempelman, R. J. Erskine, H. Hunt, and J. L. Burton, Glucocorticoid receptor down-regulation in neutrophils of periparturient cows, American Journal of Veterinary Research, 61, 14-19, 2000
  • Radke, B. R., J. W. Lloyd, R. J. Tempelman, J. B. Kaneene, J. R. Black, and S. Harsh, Parents' predicted transmitting abilities are not associated with culling prior to second lactation of Michigan, USA dairy cows, Preventive Veterinary Medicine, 43, 91-102, 2000
  • Tempelman RJ and D. Gianola, Genetic analysis of fertility in dairy cattle using negative binomial mixed models, Journal of Dairy Science, 82, 1834-1847, 1999
  • Kelly, M.E., S.D. Fitzgerald, R.J. Aulerich, R.J. Balander, D.C. Powell, R.L. Stickle, W.Stevens, C. Cray, R.J. Tempelman, S.J. Bursian, Acute effects of lead, steel, tungsten-iron, and tungsten-polymer shot administered to game-farm mallards, Journal of Wildlife Diseases, 34, 673-687, 1998
  • Truett, G.E., R. J. Tempelman, J.A. Walker and J. K. Wilson, Misty (m) affects growth traits, American Journal of Physiology, 44((Regulatory, Integra), R29-R32, 1998
  • Tempelman, R.J., Generalized linear mixed models in dairy cattle breeding, Journal of Dairy Science, 81, 1428-1444, 1998
  • Matos, C.A.P., D.L. Thomas, D. Gianola, R.J. Tempelman and L.D. Young, Genetic analysis of discrete reproductive traits in sheep using linear and nonlinear models: I. Estimation of genetic parameters, Journal of Animal Science, 75, 76-87, 1997
  • Tempelman, R.J. and D. Gianola, A mixed effects model for overdispersed count data with an animal breeding application, Biometrics, 52, 265-279, 1996
  • Chapa, A.M., J.M. Fernandez, D.L. Thompson, Jr., R. J. Tempelman, L.F. Berrio, W.J. Croom, Jr., W.M. Hagler, Jr., Endocrine and metabolic response to muscarinic stimulation and inhibition in the ruminant: effects of slaframine, Journal of Animal Science, 73, 3673-3680, 1995
  • Henderson, G., S.A. Manweiler,W.J. Lawrence, R.J. Tempelman, and L.D. Foil, The effects of Steinernema carpocapsae (Weiser) application to different life stages on adult emergence of the cat flea Ctenocephalides felis (Bouche), Veterinary Dermatology, 6, 159-163, 1995
  • Truett, G.E, R.J. Tempelman and J.A. Walker, Codominant effects of the fatty (fa) gene during early development of obesity, American Journal of Physiology, 268(Endocrinology and Me), E15-20, 1995
  • Tempelman, R.J., D. Gianola, Assessment of a Poisson animal model for embryo yield in a simulated multiple ovulation-embryo transfer scheme, Genetics, Selection, Evolution, 26, 263-290, 1994
  • Tempelman, R.J. and D. Gianola, Marginal maximum likelihood estimation of variance components in Poisson mixed models using Laplacian integration, Genetics, Selection, Evolution, 25, 305-319, 1993
  • Weigel, K.A., D. Gianola, R.J. Tempelman, C.A.P. Matos, I.H.C. Chen, T. Wang, R. Bunge, and L.L. Lo, Improving estimates of fixed effects in a mixed linear model, Journal of Dairy Science, 74, 3174-3182, 1991
  • Tempelman, R.J. and E.B. Burnside, Additive and dominance genetic variation for dairy production traits under an animal model, Journal of Animal Breeding and Genetics, 108, 330-342, 1990
  • Tempelman, R.J. and E.B. Burnside, Additive and nonadditive genetic variation for conformation traits in Canadian Holsteins, Journal of Dairy Science, 73, 2214-2220, 1990
  • Tempelman, R.J., and E.B. Burnside, Additive and nonadditive genetic variation for production traits in Canadian Holsteins, Journal of Dairy Science, 73, 2206-2213, 1990

Profile Details

Last Updated: 1/6/2009

COS Expertise ID #570421
Reference this profile directly: http://myprofile.cos.com/tempelman