Dr. Peter S. Thorne

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University of Iowa
College of Public Health
Occupational & Environmental Health
Toxicology
ProfessorAppointed: 1999
University of Iowa
College of Public Health
Occupational and Environmental Health
Deputy Departmental Executive OfficerAppointed: 2009
University of Iowa
Vice President for Research
Environmental Health Sciences Research Center
Center DirectorAppointed: 2001
University of Iowa
College of Engineering
Civil and Environmental Engineering
ProfessorAppointed: 1997
Professional Headshot of Peter S. Thorne

Mailing Address

100 Oakdale Campus
176 IREH
University of Iowa
Iowa City, Iowa 52242-5000
United States

Contact Information

Phone: (319) 335-4216
Fax: (319) 335-4006
peter-thorne@uiowa.edu
http://www.public-health.uiowa.edu/faculty-staff/faculty/directory/faculty-detail.asp?emailAddress=peter-thorne@uiowa.edu

Qualifications

Post-Doctoral Fellowship, University of Pittsburgh, Immunotoxicology, 1987.
Ph.D., University of Wisconsin-Madison, Environmental Toxicology, 1984.
M.S., University of Wisconsin-Madison, Biomedical Engineering, 1980.
B.S., University of Wisconsin-Madison, Chemical Engineering, 1978.

Expertise and Research Interests

My research is focused in the area of bioaerosol toxicology. Current principal investigations include:

Assessment of exposures to various toxicants in occupational settings with particular emphasis on organic dust and endotoxin.

Development and useof inhalation animal models for studies of pulmonary inflammatory diseases and their prevention or treatment.

Toxic effect of environmental agents that lead to immunosuppression or hypersensitivity.

Efficacy and pulmonary toxicity of antimicrobial peptides as therapeutic agents for lung infection.

Aerosol delivery of adenoviral vectors and DNA/plasmid constructs for pulmonary gene therapy.

Important aspects of my work include aerosol physics, air pollution engineering, and occupational healthand safety. I place special emphasis on organic dust exposures, bioaerosols and aeroallergens in agricultural settings and their relevance to rural health.

Keywords

COS Keywords:

Air Pollution, Asthma, Biomedical Engineering, Chemical Engineering, Clinical Trial, Environmental Health, Environmental Medicine, Environmental Toxicology, Inflammation, Occupational Health and Safety, Pulmonary Diseases, Rural Health, Toxicology.

Additional Terms:

Aerosol Physics, Air Pollution, Anti-microbial Peptide, Asthma, Bioaerosol, Clinical Trial, Endotoxin, Environment, Environmental Health, Environmental Medicine, Glucan, Health and Safety Standards, Indoor Air, Indoor Environment, Inflammation, Inflammatory Disease, Inhalation, Innatae Immunity, Lipopolysaccharide, Occupational Health and Safety, Organic Dust Exposure, Pulmonary Disease, Rural Health, Toxicology.

Memberships

American Association for Aerosol Research
American Industrial Hygiene Association
American Public Health Association
American Society for Microbiology
American Thoracic Society
British Occupational Hygiene Society
European Respiratory Society
International Society for Exposrue Assessment
Society of Toxicology

Honors and Awards

2005, Thomas Bedford Memorial Prize, British Occupational Hygiene Society
1998, Developmental assignment in The Netherlands to conduct 'International Research in Bioaerosol Toxicology',
1982, Vilas Graduate Fellowship Recipient, University of Wisconsin
1982-1984, National Research Service Award Trainee, National Institute for Environmental Health Sciences (NIEHS), University of Wisconsin
1978, Dean's High Honor List, College of Engineering, University of Wisconsin
1978, Graduate with Honors, College of Enginering, University of Wisconsin
1978, Dean's Honor List, College of Engineering, University of Wisconsin
1977, Dean's Honor List, College of Engineering, University of Wisconsin

Previous Positions

1997-1999, Professor, University of Iowa, Carver College of Medicine, Preventive Medicine, Occupational and Environmental Health - Toxicology
1996, Professor, University of Iowa, Carver College of Medicine, Preventive Medicine and Environmental Health, Occupational and Environmental Health
1992-1997, Associate Professor, University of Iowa, Carver College of Medicine, Preventive Medicine, Occupational and Environmental Health - Toxicology and Indus
1988-1992, Assistant Professor, University of Iowa, Carver College of Medicine, Preventive Medicine, Occupational and Environmental Health - Toxicology and Indus
1987-1988, Assistant Professor, University of Pittsburgh, Industrial Environmental Health Sciences
1984-1987, Faculty Associate, University of Pittsburgh, Immunotoxicology
1982-1984, National Research Service Award Trainee, University of Wisconsin-Madison, Environmental Toxicology Center
1980-1981, Teaching Assistant, University of Wisconsin-Madison, Chemical Engineering
1980-1982, Research Assistant, University of Wisconsin-Madison, Environmental Toxicology Center
1978-1980, Research Assistant, University of Wisconsin-Madison, Graduate School, Veterinary Science
1977-1977, Engineering Intern, University of Wisconsin-Madison, College of Engineering, Mechanical Engineering
1976-1976, Engineering Intern, Automative Research Associate, Inc.

Funding Received

  • NIH/UCSF: Endotoxin & Glucan Assay Analysis for UCSF (PI: PS Thorne), $30,000, Oct 1, 2002 to Sep 30, 2004.
  • NCI: Trace Elements Among Iowa Pesticide Applicators (PI: L Dennis, Co-I: PS Thorne), $100,000, Jul 1, 2003 to Jun 30, 2005.
  • NIEHS: Environmental Health Sciences Training Program (PI: PS Thorne), $554,945, Jul 1, 1998 to Jun 30, 2004.
  • NIEHS: Peer Education in Pregnancy Study (PI: V Persky) Subcontract for Endotoxin & Allergen Assays (PI: PS Thorne), $25,000, Feb 1, 2003 to Jan 31, 2004.
  • National Institutes of Health (NIH): Environmental Health Impact of CAFO's Workshop (PI: PS Thorne), $50,000, Apr 1, 2003 to Mar 31, 2004.
  • NIEHS: Exposure Intervention in a Rural Pediatric Asthma Cohort: Louisa Environmental Intervention Project (PI: PS Thorne), $1,499,785, 9/30/01 to 7/31/06.
  • Contrib from Inhalation Toxicology Facility Core: Environmental Health Sciences Research Center (EHSRC) Pilot Grant Program: Ambient Air Quality in the Vicinity of Concentrated Animal Feeding Operations (PI: PS Thorne), $20,000, 7/1/02 to 6/30/03.
  • UAW-Daimler Chrysler National Training Center: Health Hazards from Microbial Growth in Metal Working Fluids (PI: PS Thorne), $199,578, 5/21/01 to 5/20/03.
  • US DOD: An Integrated Approach Toward Understanding the Toxicity of Inhaled Nanomaterials (PI: V Grassian), $454,000, 2008 to 2012.
  • FIC/NIH: Iowa International Research and Training in Environmental & Occupational Health (PI: T Cook), $3,311,976, 2007 to 2012.
  • NIAID: Study of Genetics, Endotoxin, and Allergen (PI: K Pacheco, PI of subcontract: PS Thorne), $50,000, 2006 to 2010.
  • NIEHS: Superfund Basic Research Program: Semi-volatile PCBs: Sources, Exposures, Toxicities (PI: LW Robertson), $12,304,673, 2006 to 2010.
  • NIAID: Study of Allergen, Genetics and Endotoxin (PI: LS Newman, PS Thorne PI of subcontract), $1,250,000, 2005 to 2010.
  • NIEHS: EHSRC (Center Director: PS Thorne), 5, 737,000, 2004 to 2012.
  • NIEHS: EHSRC: Administrative Core (Center Director: PS Thorne), $283,000, 2004 to 2007.
  • NIEHS: EHSRC: Community Outreach & Educatin Core (Steering Committee: PS Thorne), $75,000, 2004 to 2007.
  • NIEHS: EHSCR: Inhalation Toxicology Facility Core (ITF) (Facility Director: PS Thorne), $112,000, 2004 to 2007.
  • US EPA: Impacts of Manufactured Nanomaterials on Human Health and the Enviroment (PI: V Grassian), $237,287, 2004 to 2007.
  • NIAID: H. Influenzae: Los and Biofilms in Pathogenesis (PI: M Apicella), $6,974,218, 2004 to 2009.
  • Iowa Department of Economic Development: Science-Based Risk Assessment for Approval of Genetically Engineered Non-Food Crops (PI: PS Thorne), $78,900, 2003 to 2005.
  • Fogarty International Center/NIH: Iowa International Research and Training in Environmental and Occupational Health (PI: T Cook), $2,237,410, 1995 to 2006.

Publications

  • Murthy S, Adamcakova-Dodd A, Perry SS, Tephly LA, Keller RM, Metwali N, Meyerholz DK, Wang Y, Glogauer M, Thorne PS, Carter AB (Aug 2009) Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis., American journal of physiology. Lung cellular and molecular physiology Abstract
  • Thorne PS, Cohn RD, Mav D, Arbes SJ, Zeldin DC (May 2009) Predictors of endotoxin levels in U.S. housing., Environmental health perspectives, 117 (5), 763-71 Abstract
  • Kulhankova K, George CL, Kline JN, Snyder JM, Darling M, Field EH, Thorne PS (Apr 2009) Early-life co-administration of cockroach allergen and endotoxin augments pulmonary and systemic responses., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Abstract
  • Zhao HX, Adamcakova-Dodd A, Hu D, Hornbuckle KC, Just CL, Robertson LW, Thorne PS, Lehmler HJ (Apr 2009) Development of a synthetic PCB mixture resembling the average polychlorinated biphenyl profile in Chicago air., Environment international Abstract
  • Klösener J, Peters TM, Adamcakova-Dodd A, Teesch L, Thorne PS, Robertson LW, Luthe G (2009) Innovative application of fluoro-tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures, Chem Res Toxicol, 22 (1), 179-86
  • Noss I, Wouters IM, Visser M, Heederik DJ, Thorne PS, Brunekreef B, Doekes G (Aug 2008) Evaluation of a low cost electrostatic dustfall collector for indoor air endotoxin exposure assessment., Applied and environmental microbiology Abstract
  • Spaan S, Doekes G, Heederik D, Thorne PS, Wouters IM (Apr 2008) Effect of extraction and assay media in the analysis of airborne endotoxin., Applied and environmental microbiology Abstract
  • Grassian VH, O'Shaughnessy PT, Adamcakova-Dodd A, Pettibone JM, Thorne PS (Apr 2008) Titanium dioxide nanoparticles: grassian et Al. Respond., Environmental health perspectives, 116 (4), A152-3 Abstract
  • Sigsgaard T, Hoffmann HJ, Thorne PS (Apr 2008) The role of innate immunity in occupational allergy: recent findings., Current opinion in allergy and clinical immunology, 8 (2), 120-125 Abstract
  • Salo PM, Arbes SJ, Crockett PW, Thorne PS, Cohn RD, Zeldin DC (Mar 2008) Exposure to multiple indoor allergens in US homes and its relationship to asthma., The Journal of allergy and clinical immunology, 121 (3), 678-684.e2 Abstract
  • Hadina S, Weiss JP, McCray Jr PB, Kulhankova K, Thorne PS (Jan 2008) MD-2-dependent Pulmonary Immune Responses to Inhaled Lipooligosaccharides: Effect of Acylation State. Abstract
  • Douwes J, Eduard W, Thorne PS (2008) Bioaerosols, Internataional Encyclopedia of Public Health, Vol 1 Edition, San Diego, Academic Press, 287-97 pages (bookchapter)
  • Lee JA, Thorne PS, Reynolds SJ, O'Shaughnessy PT (2007) Monitoring risks in association with exposure levels among wastewater treatment plant workers, J Occup Environ Med, 49 (11), 1235-48
  • Spaan S, Heederik DJ, Thorne PS, Wouters IM (2007) Optimization of airborne endotoxin exposure assessment: effects of filter type, transport conditions, extraction solutions and storage of samples and extracts, Appl Environ Microbiol
  • Thorne PS (2007) CAFOs: Thorne Responds, Environ Health Perspect., 115 (7), A343-4
  • Grassian VH, O'Shaughnessy PT, Adamcakova-Dodd A, Pettibone JM, Thorne PS (2007) Pettibone JM, Thorne PS. "Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm, Environ Health Perspect, 115 (3), 397-402
  • Thorne PS (2007) Environmental health impacts of concentrated animal feeding operations: anticipating hazards--searching for solutions, Environ Health Perspect, 115 (2), 296-7
  • Gilchrist MJ, Greko C, Wallinga DB, Beran GW, Riley DG, Thorne PS (2007) The potential role of concentrated animal feeding operations in infectious disease epidemics and antibiotic resistance, Environ Health Perspect, 115 (2), 313-6
  • Donham KJ, Wing S, Osterberg D, Flora JL, Hodne C, Thu KM, Thorne PS (2007) Community health and socioeconomic issues surrounding concentrated animal feeding operations, Environ Health Perspect, 115 (2), 317-20
  • George CL, White ML, Kulhankova K, Mahajan A, Thorne PS, Snyder JM, Kline JN (2006) Early exposure to organic dust alters pulmonary immunity and allergic responses., Am J Physiol Lung Cell Mol Physiol, 291 (3), L512-22
  • Mueller-Anneling LJ, O'Neill ME, Thorne PS (2006) Biomonitoring for assessment of organic dust-induced lung inflammation, Eur Respir J, 27 (6), 1096-102
  • Perzanowki MS, Miller RL, Thorne PS, Barr RG, Divjan A, Sheares BJ, Garfinkel RS, Goldstein IF, Perera FP, Chew GL (2006) Endotoxin inner-city homes and the association with atopy and wheeze in the first two years of life, J Allergy Clin Immunol, 117 (5), 1082-9
  • Thorne PS, Adamcakova-Dodd A, Kelly KM, O'neill ME, Duchaine C (2006) Metal working fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in mice, Am J Respir Crit Care Med, 173 (7), 759-68
  • Chun DT, Bartlett K, Gordon T, Jacobs RR, Larsson BM, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown ME, Gunn VS, Wurtz H (2006) History and results of the two inter-laboratory round robin endotoxin assay studies on cotton dust, Am J Ind Med, 49 (4), 301-6
  • Rao CY, Riggs MA, Chew GL, Muilenberg ML, Thorne PS, Sickle DV, Dunn KH, Brown C (2006) Characterizing airborne molds, endotoxins and glucans in homes in New Orleans after Hurricanes Katrina and Rita, Appl Environ Microbiol
  • Lee JA, Johnson JC, Reynolds SJ, Thorne PS, O'Shaughnessy PT (2006) Indoor and outdoor air quality assessment of four wastewater treatment plants, Journal of Occupational and Environmental Hygiene, 3, 36-43
  • Svendsen ER, O'Shaughnessy PT, Reynolds SJ, Quinones A, Zimmerman D (2006) House dust collection efficiency of the high volume small surface sampler on worn carpets, J Occup Environ Hyg, 3, 334-41
  • Thorne PS, Kulhankova K, Yin M, Cohn R, Arbes SJ, Zeldin DC (2005) Endotoxin exposure is a risk factor for asthma - The National Survey of Endotoxin in United States Housing, American Journal of Respiratory & Critical Care Medicine, 172 (11), 1371-7
  • Blanc PD, Eisner MD, Katz PP, Yen IH, Archea C, Earnest G, Janson S, Masharani UB, Quinlan PJ, Hammond SK, Thorne PS, Balmes JR, Trupin L, Yelin EH, Impact of the Home Indoor Environment on Adult Asthma and Rhinitis., Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine., 47(4), 362-72, Apr 2005 Abstract
  • McConnell R, Milam J, Richardson J, Galvan J, Jones C, Thorne PS, Berhane K, Educational Intervention to Control Cockroach Allergen Exposure in the Homes of Hispanic Children in Los Angeles: Results of the La Casa Study., Clinical & Experimental Allergy, 35(4), 426-33, Apr 2005
  • Merchant JA, Naleway AL, Svendsen ER, Kelly KM, Burmeister LF, Stromquist AM, Taylor CD, Thorne PS, Reynolds SJ, Sanderson WT, Chrischilles EA, Asthma and Farm Exposures in a Cohort of Rural Iowa Children, Environmental Health Perspectives, 113(3), 350-6, 2005
  • Reynolds SJ, Milton DK, Heederik D, Thorne PS, Donham KJ, Croteau EA, Kelly KM, Douwes J, Lewis D, Whitmer M, Connaughton I, Koch S, Malmberg P, Larsson BM, Deddens J, Saraf A, Larsson L (2005) Interlaboratory evaluation of endotoxin analyses in agricultural dusts - comparison of LAL assay and mass spectrometry, Journal of Environmental Monitoring, 7 (12), 1371-7
  • Thorne PS, Metwali N, Avol E, McConnell R (2005) Surface sampling for endotosin assessment using electrostatic wiping cloths, Ann Occup Hyg, 49 (5), 401-6
  • Veillette M, Page G, Thorne PS, Duchaine C (2005) Recovery and quantification of mycobacterium immunogenum DNA from metalworking fluids using dual-labeled probes, ASTM International, 2 (4), 1-9
  • Beane Freeman LE, Dennis LK, Thorne P, Lynch C, Toenail arsenic content and cutaneous melanoma in Iowa, Am J Epidemiology, 160(7), 1 October 2004
  • Thorne PS, Duchaine C, Douwes J, Eduard W, Gorny R, Jacobs R, Reponen T, Schierl R, Szponar B, Working Group report 4: exposure assessment for biological agents, American Journal of Industrial Medicine, 46(4), 419-22, Oct 2004 Abstract
  • Durairaj L, Launspach J, Watt JL, Businga TR, Kline JN, Thorne PS, Zabner J, Safety assessment of inhaled xylitol in mice and healthy volunteers - art. no. 13, Respiratory Research, 5(13), 13, 16 Sep 2004
  • Veillette M, Thorne PS, Gordon T, Duchaine C, Six month tracking of microbial growth in a metalworking fluid after system cleaning and recharging, The Annals of Occupational Hygiene, 48(6), 541-6, August 2004 Abstract
  • Mueller-Anneling L, Avol E, Peters JM, Thorne PS, Ambient endotoxin concentrations in PM10 from Southern California, Environmental Health Perspectives, 112(5), 583-8, 2004
  • Doerschug KC, Powers LS, Monick MM, Thorne PS, Hunninghake GW, Antibiotics delay but do not prevent bacteremia and lung injury in murine sepsis, Critical Care Medicine, 32(2), 489-94, February 2004 Abstract
  • Chrischilles E, Ahrens R, Kuehl A, Kelly KM, Thorne PS, Burmeister LF, Merchant JA, Asthma prevalence and morbidity among rural Iowa school children, Journal of Allergy and Clinical Immunology, 113(1), January 2004
  • Bartlett KH, McCray PB Jr, Thorne PS, Reduction in the bactericidal activity of selected cathelicidin peptides by bovine calf serum or exogenous endotoxin, Int J Antimicrob Agents, 23(6), 606-12, 2004
  • Lee K, Lawson RJ, Olenchock SA, Vallyathan V, Southard RJ, Thorne PS, Saiki C, Schenker MB, Personal exposures to inorganic and organic dust in manual harvest of California citrus and table grapes, J Occup Environ Hyg, 1(8), 505-14, 2004
  • Bartlett KH, McCray PB Jr, Thorne PS, Novispirin G10-Induced Lung Toxicity in a Klebsiella pneumoniae Infection Model, Antimicrobial Agents and Chemotherapy, 47(12), 3901-6, December 2003 Abstract
  • Carney CP, Sampson TR, Voelker M, Woolson R, Thorne P, Doebbeling BN, Women in the Gulf War: combat experience, exposures, and subsequent health care use, Military Medicine, 168(8), 654-61, August 2003 Abstract
  • Thorne PS, Correspondence: asthma and gulf war exposures: response, Environmental Health Perspectives, 111(9), A452, July 2003 Abstract
  • Pacheco KA, McCammon C, Liu AH, Thorne PS, O'Neill ME, Martyny J, Newman LS, Hamman RF, Rose CS, Airborne Endotoxin Predicts Symptoms in Non-Mouse-sensitized Technicians and Research Scientists Exposed to Laboratory Mice, American Journal of Respiratory and Critical Care Medicine, 167(7), 983-90, April 2003 Abstract
  • O'Shaughnessy PT, Achutan C, O'Neill ME, Thorne PS, A small whole-body exposure chamber for laboratory use, Inhalation Toxicology, 15(3), 251-63, March 2003
  • Douwes J, Thorne PS, Heedrik D, Monitoring and evaluation of bioaerasol exposure, Journal for Applied Health and Safety Studies, (in press), 2003
  • Thorne PS, Bartlett KH, Phipps J, Kulhankova K, Evaluation of five extraction protocols for quantification of endotoxin in metalworking fluid (MWF) aerosol, Annals of Occupational Hygiene, 47(1), 31-36, January 2003
  • Douwes J, Thorne PS, Pearce N, Heedrik D, Bioaerosol health affects and exposure assessment: progress and prospects, Annals of Occupational Hygiene, 47(3), 187-200, 2003
  • Roy CJ, Thorne PS, Exposure to particulates, microorganisms, â(1-3) glucans and endotoxins during soybean harvesting, Am Ind Hyg Assoc J, 64(4), 487-95, 2003
  • Chun DTW, Chew V, Bartlett K, Gordon T, Jacobs RR, Larsson B-M, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown ME., A round robin endotoxin assay study using cotton dust. Appl Occup Envir Hyg, (in press), 2003
  • Kullman GJ, Thorne PS, Marx JJ, Ault B, Olenchock SA, Merchant JA., Organic dust exposures and respiratory symptoms among dairy farmers, Am J Ind Med, (in press), 2003
  • Wouters I, Douwes J, Thorne PS, Heederik D, Doekes G., Inter- and Intra- individual variation of endotoxin and B(1à3) – glucan induced cytokine responses in a whole blood assay, Toxicol Industr Health, (in press), 2003
  • Vojta PJ, Freedman W, Marker DA, Clickner R, Rogers JW, Viet SM, Muilenberg ML, Thorne PS, Arbes SJ Jr, Zeldin DC, First national survey of lead and allergens in housing: survey design and methods for the allergen and endotoxin components, Environmental Health Perspectives, 110(5), 527-32, 2002
  • Heederik D, Thorne PS, Doekes G, Health-based occupational exposure limits for high molecular weight sensitizers: How long is the road we must travel?, Annals of Occupational Hygiene, 46(5), 439-46, 2002
  • Reynolds SJ, Thorne PS, Donham KJ, Croteau EA, Kelly KM, Lewis D, Whitmer M, Heederik D, Douwes J, Connaughton I, Koch S, Malmberg P, Larsson B-M, Milton DK, Interlaboratory comparison of endotoxin assays using agricultural dusts, American Industrial Hygiene Association Journal, 63(4), 430-8, 2002
  • Chun DTW, Chew V, Bartlett K, Gordon T, Jacobs RR, Larsson B-M, Lewis DM, Liesivuori J, Michel O, Rylander R, Thorne PS, White EM, Gunn VC, Würtz H, Second interlaboratory study comparing endotoxin assay results from cotton dust, Annals of Agricultural and Environmental Medicine, 9, 49-53, 2002
  • Lange JL, Schwartz DA, Doebbeling BN, Heller JM, Thorne PS, Exposures to the Kuwait oil fires and their association with asthma and bronchitis among Gulf War Veterans, Environmental Health Perspectives, 110(ll), 1141-6, 2002
  • Kullman GJ, Thorne PS, Marx JJ, Ault B, Olenchock SA, Merchant JA, Organic dust exposures and respiratory symptoms among dairy farmers, American Journal of Industrial Medicine, (in press), 2002
  • Carney C, Sampson T, Voelker M, Woolson RF, Thorne PS, Doebbeling BN., Women in theater: The Gulf War experience in combat, Military Medicine, (in press), 2002
  • O’Shaughnessy PT, Achutan C, O'Neill ME, Thorne PS, A small whole-body exposure chamber for laboratory use, Inhalation Toxicology, (in press), 2002
  • Roy CJ, Thorne PS., Exposure to particulates, microorganisms, â(1-3) glucans and endotoxins during soybean harvesting, American Industrial Hygiene Association Journal, (in press), 2002
  • Wouters I, Douwes J, Thorne PS, Heederik D, Doekes G, Inter- and Intra- individual variation of endotoxin and B(1à3) – glucan induced cytokine reponses in a whole blood assay, Toxicology and Industrial Health, (in press), 2002
  • Pacheco KA, McCammon C, Liu AH, Thorne PS, O’Neill ME, Martyny J, Newman LS, Hamman RF, Rose CS, Airborne endotoxin predicts symptoms in nonsensitized technicians and research scientists exposed to laboratory animals, American Journal of Respiratory and Critical Care Medicine, (in press), 2002
  • Chun DTW, Chew V, Bartlett K, Gordon T, Jacobs RR, Larsson B-M, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown ME, A round robin endotoxin assay study using cotton dust, Applied Occupational and Environmental Hygiene, (in press), 2002
  • George CL, Jin H, Wohlford-Lenane CL, O'Neill ME, Phipps JC, O'Shaughnessy P, Kline JN, Thorne PS, Schwartz DA, Endotoxin responsiveness and subchronic grain dust-induced airway disease, American Journal of Physiology. Lung Cellular and Molecular Physiology, 280(2), L203-13, February 2001 Abstract
  • Chun DT, Bartlett K, Chew V, Gordon T, Jacobs RR, Larsson B-M, Lewis DM, Liesivuori J, Michel O, Rylander R, Thorne PS, White EM, Brown ME, Wurtz H., Second interlaboratory study comparing endotoxin assay results from cotton dust, Proceedings of the Beltwide Cotton Conferences; Jan 9-13; Anaheim, CA. National Cotton Council of America, Memphis, TN, 2001
  • Duchaine C, Thorne PS, Meriaux A, Grimard Y, Whitten P, Cormien Y, Comparison of endotoxin exposure assessment by bioaerosol impinger and filter sampling methods, Applied and Environmental Microbiology, 67(6), 2775-80, 2001
  • Reynolds SJ, Black DW, Borin S, Breuer G, Burmeister LF, Fuortes LJ, Smith TF, Stein M, Subramanian P, Thorne PS, Whitten P, Indoor environmental quality in six commercial office buildings in the Midwest United States, Applied Occupational and Environmental Hygiene, 16(11), 1065-77, 2001
  • Thorne PS, Inhalation toxicology models of endotoxin- and bioaerosol-induced inflammation, Toxicology, 152(1-3), 13-23, November 2000 Abstract
  • Mueller-Anneling L, Gilchrist MJ, Thorne PS, Ehrlichia chaffeensis antibodies in white-tailed deer, Iowa, 1994 and 1996, Emerging Infectious Diseases, 6(4), 397-400, 2000 Abstract
  • Wouters IM, Douwes J, Doekes G, Thorne PS, Heederik DJJ, Increased levels of markers of microbial exposure in homes with indoor storage of organic household waste, Applied and Environmental Microbiology, 66(2), 627-31, 2000
  • Howard WT, Loberiza FR, Pfohl BM, Woolson RF, Magpantay RL, Thorne PS, Logistical and methodological challenges in conducting a survey of Mount Pinatubo disaster victims, Transcultural Psych, 37, 101-18, 2000
  • Duchaine C, Meriaux A, Thorne PS, Cormier Y, Assessment of particulates and bioaerosols in Eastern Canadian sawmills, American Industrial Hygiene Association Journal, 61(5), 727-32, 2000
  • Wouters IM, Douwes J, Doekes G, Thorne PS, Heederik DJJ, Increased levels of markers of microbial exposure in homes with indoor storage of organic household waste, Applied and Environmental Microbiology, 66(2), 627-31, 2000
  • Chun DT, Chew V, Bartlett K, Gordon T, Jacobs RR, Larsson B-M, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown ME, Preliminary report on the results of the second phase of a round-robin endotoxin assay study using cotton dust, Applied Occupational and Environmental Hygiene, 15(1), 152-7, 2000
  • Mahar S, Reynolds SJ, Thorne PS, Worker exposures to particulates, endotoxins, and bioaerosols in two refuse-derived fuel plants, American Industrial Hygiene Association Journal, 60(5), 679-83, 1999 Abstract
  • McCray PB Jr, Zabner J, Jia HP, Welsh MJ, Thorne PS, Efficient killing of inhaled bacteria in DeltaF508 mice: role of airway surface liquid composition., American Journal of Physiology, 277(1 Pt 1), L183-90, July 1999 Abstract
  • Thorne PS, McCray PB, Howe TS, O''Neill MA, Early-onset inflammatory responses in vivo to adenoviral vectors in the presence or absence of lipopolysaccharide-induced inflammation., American Journal of Respiratory Cell and Molecular Biology, 20(6), 1155-64, June 1999 Abstract
  • Nonnenmann MW, Rautiainen RH, Donham KJ, Kirychuk SP, Reynolds SJ, O'Shaughnessy PT, Thorne PS., Vegetable oil sprinkling as a dust reduction method in a swine confinement, Proceedings of the International Symposium on Dust Control in Animal Production Facilities, Aarhus, Denmark, 271-8, May 30-Jun2, 1999
  • Kirychuk S, Donham K, Reynolds S, Burmeister L, Barber E, Thorne P, Senthilselvan A, Rautiainen R, Oil/water sprinkling intervention in a swine building, Proceedings of the International Symposium on Dust Control in Animal Production Facilities, Aarhus, Denmark, 335-42, May 30-Jun 2, 1999
  • Chun DT, Chew V, Gordon T, Jacobs RR, Larsson B-M, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown M, A quick summary of the highlights of parts 1 and 2 of the first round robin endotoxin assay study and a brief preview of the next round, 1999 Proceedings of the Beltwide Cotton Conferences, Orlando, FL, 1, 132-38, Jan 1999
  • Howard WT, Loberiza FR, Pfohl BM, Woolson RF, Magpantay RL, Thorne PS, Initial results, reliability, and validity of a mental health survey of Mount Pinatubo disaster victims, Journal of Nervous and Mental Dis, 187, 661-672, 1999
  • Mahar S, Thorne PS., Respiratory, gastrointestinal, and other health effects among workers in two refuse-derived fuel plants, Arhiv Za Higijenu Rada i Toksikologiju, 50(3), 249-61, 1999
  • Kullman G J, Thorne P S, Waldron P F, Marx J J, Ault B, Lewis D M, Siegel P D, Olenchock S A, Merchant J A, Organic dust exposures from work in dairy barns., American Industrial Hygiene Association Journal, 59(6), 403-13, June 1998 Abstract
  • Kline J N, Waldschmidt T J, Businga T R, Lemish J E, Weinstock J V, Thorne P S, Krieg A M, Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma., Journal of Immunology, 160(6), 2555-9, 15 Mar 1998 Abstract
  • Reynolds SJ, Chao DY, Thorne PS, Subramanian P, Waldron PF, Selim M, Whitten PS, Popendorf WJ, Field comparison of methods for evaluation of vapor/particle phase distribution of ammonia in livestock buildings, Journal of Agricultural Safety and Health, 4(2), 81-93, 1998
  • Heederik D, Thorne PS, section editors, Exposures in agricultural populations affecting respiratory health. In: Schenker MB, et al. Respiratory Health Hazards in Agriculture, American Journal of Respiratory and Critical Care Medicine Supplement, 158(Part 2), S1-S76, 1998
  • Skorska C, Mackiewicz B, Dutkiewicz J, Krysinska-Traczyk E, Milanowski J, Feltovich H, Lange J, Thorne PS, Effects of exposure to grain dust in Polish farmers: work-related symptoms and immunologic response to microbial antigens assosicated with dust, Annals of Agricultural and Environmental Medicine, 5, 147-53, 1998
  • Chun DT, Chew V, Bartlett K, Gordon T, Jacobs RR, Larsson B, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown ME, Preliminary report on the results of the first phase of a round robin endotoxin assay study using cotton dust. In: Dugger P, Richter DA, editorial coordinators, 1998 Proceedings of the Beltwide Cotton Conferences; Jan 5-9; San Diego, CA. National Cotton Council of America, Memphis, TN, 1, 195-8, 1998
  • Reynolds SJ, Black DW, Breuer G, Burmeister LF, Fuortes LJ, Smith TF, Stein M, Subramanian P, Thorne PS, Whitten P, Indoor environmental quality in large office buildings in the Midwest U.S, In: Measurement of Toxic and Related Air Pollutants, Proceedings of a Specialty Conference Cosponsored by the Air & Waste Management Association and the U.S. Environmental Protection Agency’s National Exposure Research Laboratory, 1, 207-23, 1998
  • Fuortes L J, Weih L, Pomrehn P, Thorne P S, Jones M, Burmeister L, Merchant J A, Prospective epidemiologic evaluation of laboratory animal allergy among university employees., American Journal of Industrial Medicine, 32(6), 665-9, December 1997 Abstract
  • Thorne P S, Reynolds S J, Milton D K, Bloebaum P D, Zhang X, Whitten P, Burmeister L F, Field evaluation of endotoxin air sampling assay methods., American Industrial Hygiene Association Journal, 58(11), 792-9, November 1997 Abstract
  • Schwartz D A, Quinn T J, Thorne P S, Sayeed S, Yi A K, Krieg A M, CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract., Journal of Clinical Investigation, 100(1), 68-73, 1 Jul 1997 Abstract
  • Reynolds S J, Etre L, Thorne P S, Whitten P, Selim M, Popendorf W J, Laboratory comparison of vacuum, OSHA, and HUD sampling methods for lead in household dust., American Industrial Hygiene Association Journal, 58(6), 439-46, June 1997 Abstract
  • Lange J L, Thorne P S, Lynch N, Application of flow cytometry and fluorescent in situ hybridization for assessment of exposures to airborne bacteria., Applied and Environmental Microbiology, 63(4), 1557-63, April 1997 Abstract
  • Sprince N L, Thorne P S, Popendorf W, Zwerling C, Miller E R, DeKoster J A, Respiratory symptoms and lung function abnormalities among machine operators in automobile production., American Journal of Industrial Medicine, 31(4), 403-13, April 1997 Abstract
  • Deetz D C, Jagielo P J, Quinn T J, Thorne P S, Bleuer S A, Schwartz D A, The kinetics of grain dust-induced inflammation of the lower respiratory tract., American Journal of Respiratory and Critical Care Medicine, 155(1), 254-9, January 1997 Abstract
  • Thu K, Donham K, Ziegenhorn R, Reynolds S, Thorne PS, Subramanian P, Whitten P, Stookesberry J, A control study of the physical and mental health of residents living near a large-scale swine operation, Journal of Agricultural Safety and Health, 3(1), 13-26, 1997
  • Reynolds SJ, Donham KJ, Stookesberry J, Thorne PS, Subramanian P, Thu K, Whitten P, Air quality assessments in the vicinity of swine production facilities, Journal of Agromedicine, 4, 37-45, 1997
  • Lange JL, Thorne PS, Kullman GJ, Determinants of viable bioaerosol concentrations in dairy barns, Annals of Agricultural and Environmental Medicine, 4, 187-94, 1997
  • The Iowa Persian Gulf Study Group, Thorne PS, Self-reported illness and health status among Gulf War veterans: A population-based study, JAMA, 277(3), 238-45, 1997
  • Thorne PS, Subramanian P, Sutphin JE, O’Neill ME, Rautiainen R, Reynolds SJ, Merchant JA, Ocular trauma from ballast fluid after a tractor tire explosion, Journal of Agricultural Safety and Health, 3(1), 41-54, 1997
  • Thorne P S, DeKoster J A, Pulmonary effects of machining fluids in guinea pigs and mice., American Industrial Hygiene Association Journal, 57(12), 1168-72, December 1996 Abstract
  • Popendorf W, Miller E R, Sprince N L, Selim M S, Thorne P S, Davis C S, Jones M L, The utility of preliminary surveys to detect the cause of acute metalworking fluid hazards., American Journal of Industrial Medicine, 30(6), 744-9, December 1996 Abstract
  • Sprince N L, Palmer J A, Popendorf W, Thorne P S, Selim M I, Zwerling C, Miller E R, Dermatitis among automobile production machine operators exposed to metal-working fluids., American Journal of Industrial Medicine, 30(4), 421-9, October 1996 Abstract
  • Blaski C A, Clapp W D, Thorne P S, Quinn T J, Watt J L, Fress K L, Yagla S J, Schwartz D A, The role of atopy in grain dust-induced airway disease., American Journal of Respiratory and Critical Care Medicine, 154(2 Pt 1), 334-40, August 1996 Abstract
  • Jagielo P J, Thorne P S, Watt J L, Frees K L, Quinn T J, Schwartz D A, Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects., Chest, 110(1), 263-70, July 1996 Abstract
  • Jagielo P J, Thorne P S, Kern J A, Quinn T J, Schwartz D A, Role of endotoxin in grain dust-induced lung inflammation in mice., American Journal of Physiology, 270(6 Pt 1), L1052-9, June 1996 Abstract
  • Blaski C A, Watt J L, Quinn T J, Thorne P S, Schwartz D A, Nasal lavage cellularity, grain dust, and airflow obstruction., Chest, 109(4), 1086-92, April 1996 Abstract
  • Fuortes L J, Weih L, Jones M L, Burmeister L F, Thorne P S, Pollen S, Merchant J A, Epidemiologic assessment of laboratory animal allergy among university employees., American Journal of Industrial Medicine, 29(1), 67-74, January 1996 Abstract
  • Subramanian P, Teesch LM, Thorne PS, Degradation of 3,5-dimethyl-tetrahydro-2H-1,3,5-thiadiazine-2-thione in aqueous aerobic media, Environmental Toxicology and Chemistry, 15(4), 503-13, 1996
  • Thorne PS, DeKoster JA, Subramanian P, Environmental assessment of aerosols, bioaerosols, and airborne endotoxin in a machining plant, American Industrial Hygiene Association Journal, 57(12), 1163-7, 1996
  • Subramanian P, Reynolds S, Thorne PS, Donham K, Stookesberry J, Thu K, Assessment of airborne ammonia in a swine farming environment by the fluorimetric enzyme method, International Journal of Environmental and Analytical Chemistry, 64, 301-12, 1996
  • Schwartz D A, Thorne P S, Yagla S J, Burmeister L F, Olenchock S A, Watt J L, Quinn T J, The role of endotoxin in grain dust-induced lung disease., American Journal of Respiratory and Critical Care Medicine, 152(2), 603-8, August 1995 Abstract
  • Kiekhaefer MS, Donham KJ, Whitten P, Thorne PS, Cross seasonal studies of airborne microbial populations and environment in swine buildings: Implications for worker and animal health, Annals of Agricultural and Environmental Medicine, 2, 37-44, 1995
  • DeKoster JA, Thorne PS, Bioaerosol concentrations in non-complaint, complaint, and intervention homes in the Midwest, American Industrial Hygiene Association Journal, 56, 573-80, 1995
  • Schwartz D A, Thorne P S, Jagielo P J, White G E, Bleuer S A, Frees K L, Endotoxin responsiveness and grain dust-induced inflammation in the lower respiratory tract., American Journal of Physiology, 267(5 Pt 1), L609-17, November 1994 Abstract
  • Thorne P S, Lange J L, Bloebaum P, Kullman G J, Bioaerosol sampling in field studies: can samples be express mailed?, American Industrial Hygiene Association Journal, 55(11), 1072-9, November 1994 Abstract
  • Clapp W D, Becker S, Quay J, Watt J L, Thorne P S, Frees K L, Zhang X, Koren H S, Lux C R, Schwartz D A, Grain dust-induced airflow obstruction and inflammation of the lower respiratory tract., American Journal of Respiratory and Critical Care Medicine, 150(3), 611-7, September 1994 Abstract
  • Thorne P S, Experimental grain dust atmospheres generated by wet and dry aerosolization techniques., American Journal of Industrial Medicine, 25(1), 109-12, January 1994 Abstract
  • Donham K J, Thorne P S, Agents in organic dust: criteria for a causal relationship., American Journal of Industrial Medicine, 25(1), 33-9, January 1994 Abstract
  • Lacey J, Auger P, Eduard W, Norn S, Rohrbach MS, Thorne PS, Tannins and mycotoxins, American Journal of Industrial Medicine, 25, 141-4, 1994
  • Clapp W D, Thorne P S, Frees K L, Zhang X, Lux C R, Schwartz D A, The effects of inhalation of grain dust extract and endotoxin on upper and lower airways., Chest, 104(3), 825-30, September 1993 Abstract
  • Thorne P S, Sump additives as a source of bioaerosols in a school building., Veterinary and Human Toxicology, 35(2), 141-3, April 1993 Abstract
  • Thorne P S, Kiekhaefer M S, Whitten P, Donham K J, Comparison of bioaerosol sampling methods in barns housing swine., Applied and Environmental Microbiology, 58(8), 2543-51, August 1992 Abstract
  • Schmidt L E, Thorne P S, Watt J L, Schwartz D A, Is an abbreviated bronchial challenge with histamine valid?, Chest, 101(1), 141-5, January 1992 Abstract
  • Thorne P S, Hawk C, Kaliszewski S D, Guiney P D, The noninvasive mouse ear swelling assay. I. Refinements for detecting weak contact sensitizers [see comments], Fundamental and Applied Toxicology, 17(4), 790-806, November 1991 Abstract
  • Thorne P S, Hawk C, Kaliszewski S D, Guiney P D, The noninvasive mouse ear swelling assay. II. Testing the contact sensitizing potency of fragrances., Fundamental and Applied Toxicology, 17(4), 807-20, November 1991 Abstract
  • Karol MH, Hillebrand JA, Thorne PS, Characteristics of weekly pulmonary hypersensitivity responses elicited in the guinea pig by inhalation of ovalbumin aerosols, Toxicology and Applied Pharmacology, 100, 234-6, 1989
  • Thorne PS, Karol MH, Association of fever with late-onset pulmonary hypersensitivity responses in the guinea pig, Toxicology and Applied Pharmacology, 100, 247-58, 1989
  • Thorne PS, Karol MH, Assessment of airway reactivity in guinea pigs: Comparison of methods employing whole body plethysmography, Toxicology, 52, 141-63, 1988
  • Karol MH, Thorne PS, Hillebrand J, The immune response as a biological indicator of exposure, Proceedings of the International Symposium on Biochemical & Cellular Indices of Human Toxicity in Occupational Environmental Medicine, Occupational & Environmental Chemical Hazards, 6, 86-90, 1987
  • Lightfoot EN, Thorne PS, Jones RL, Hansen JL, Romine RR, Laboratory studies on mechanisms for the degradation of aldicarb, aldicarb sulfoxide, and aldicarb sulfone, Environmental Toxicology and Chemistry, 6, 377-94, 1987
  • Hillebrand JA, Thorne PS, Karol MH, Experimental sensitization to subtilisin. II. production of specific antibodies following inhalation exposure of guinea pigs, Toxicology and Applied Pharmacology, 449-456, 1987
  • Thorne PS, Yeske CP, Karol MH, Monitoring guinea pig core temperature by telemetry during inhalation exposures, Fundamental and Applied Toxicology, 9, 398-408, 1987
  • Thorne PS, Hillebrand J, Magreni C, Riley EJ, Karol MH., Experimental sensitization to subtilisin: I. production of immediate and late-onset pulmonary reactions, Toxicology and Applied Pharmacology, 86, 112-123, 1986
  • Jones WG, Thorne PS, Clere JL, Low cost polarized light microscopy, Applied Industrial Hygiene, 1, 191-5, 1986
  • Thorne PS, Hillebrand JA, Lewis GR, Karol MH, Contact sensitivity by diisocyanates: potencies and cross-reactivities, Toxicology and Applied Pharmacology, 87, 155-65, 1986
  • Olaniran N, Thorne PS, Ellakkani M, Karol MH, Serologic evaluation of guinea pigs exposed during twelve months to cotton dust. In: Wakelyn PJ, Jacobs RR, editors. Cotton Dust, Proceedings of the Tenth Cotton Dust Research Conference, 134-7, 1986
  • Cockrell B, Ellakkani M, Thorne PS, Karol MH, Histopathology of guinea pigs exposed for 12 months to cotton dust. In: Wakelyn PJ, Jacobs RR, editors. Cotton Dust, Proceedings of the Tenth Cotton Dust Research Conference, 138-9, 1986
  • Thorne PS, Lightfoot EN, Albrecht RM, Physicochemical characterization of cryogenically ground, size separated, fibrogenic particles, Environmental Research, 36, 89-110, 1985
  • Fischer JJ, Ellakkani M, Thorne PS, Weyel D, Alarie Y, Karol MH, Endotoxin activity and microbial study of cotton dust particles of known sizes. In: Jacobs RR, Wakelyn PJ, editors. Cotton Dust, Proceedings of the Ninth Cotton Dust Research Conference, 144-45, 1985
  • Thorne PS, Lightfoot EN, Gonder JC, Will JA, Animal chamber for in vivo testing of toxic gases, Laboratory Animal Science, 33, 476-80, 1984
  • Lightfoot EN, Thorne PS, Stoll LL, Dimensionless presentation of performance data for fans and blowers, American Institute of Chemical Engineers Journal, 30, 341-5, 1984

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