Dr. Wolfgang A. Tomé

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University of Wisconsin-Madison
School of Medicine and Public Health
Human Oncology and Medical Physics
Associate Professor (Tenure)Appointed: 2006
Professional Headshot of Wolfgang A. Tomé

Mailing Address

600 Highland Avenue
CSC K4/314
Madison, Wisconsin 53792-0600
United States

Contact Information

Phone: (608) 263-8510
Fax: (608) 263-9947
wtome@wisc.edu

Qualifications

Ph.D., University of Florida, Physics, 1995.
M.Sc., University of Denver, Physics, 1989.
Vordiplom, Eberhard-Karls Universitaet, Physik, 1986.

Expertise and Research Interests

My research interests include:
Biomathematical Modeling of Cancer Treatments
Multimodality Imaging using MRSI, Perfusion and Diffusion MRI
Multimodality Image Guided Radiation Therapy
Optical Guided Fractionated Stereotactic Radiation Therapy
Optical Guided 3D Ultrasound Target Localization
Optical Guided Intensity Modulated Radiation Therapy (IMRT)
Quality Assurance Methods for IMRT
Stereotactic Radiosurgery

Future Research

My current and future research efforts are directed towards incorporating advanced imaging techniques into the radiotherapy planning process. These adavnced imaging techniques include chemical shift imaging (CSI), which can identify malignant cells by their metabolic "fingerprint," blood oxygen-dependent imaging (BOLD MR), which can identify hypoxic regions in tumors, and Perfusion MR, which can identify regions of neovascularization in rapidly developing malignant tissue, Diffusion MR, which can identify regions of active cell proliferation within a tumor. It is hypothesized that the incorporation of these new imaging modalities in radiation treatment planning process will allow the planner to determine the extend of the tumor more accurately and aid theplanner in determining regions within the tumor that may be boosted to higher radiation doses, and therefore increase tumor control.

Funding Received

  • Philips Radiation Onoclogy Systems: Development of IMRT treatment planning techniques for tumor volumes defined using advanced imaging techniques, $287,000, Oct 1, 2002 to Sep 30, 2005.
  • ADAC Laboratories: Incorporation of advanced imaging techniques into radiotherapy planning, $135,000, Oct 1, 2000 to Sep 30, 2002.
  • National Institutes of Health (NIH): Intracranial conformal avoidance radiotherapy (RO-1), $675,000, 2005 to 2008.
  • ADAC Laboratories: ADAC Development Grant, $75,000, 1999 to 2000.
  • Wisconsin Alumni Research Foundation: UIR-IND & ECON DEV AWARD, $29,902, 1999 to 2000.
  • University of Florida Division of Sponsored Research: Graduate Research, $9,207, 1993 to 1994.

Publications

  • Bentzen, SM, Harari, PM, Tomé, WA, Mehta, MP (2007) Radiation Oncology Advances, 1 Edition, Vol. 139, Cancer Treatment and Research, Berlin, London, New York, Springer, 344 pages, ISBN=978-0-387-367
  • Gutíerrez AN, Deveau M, Forrest LJ, Tomé WA, Mackie TR (2007) Radiobiological and treatment planning study of a simultaneously integrated boost for canine nasal tumors using helical tomotherapy., Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 48 (6), 594-602 Abstract
  • Kim Y, Tomé WA (Nov 2007) On the radiobiological impact of metal artifacts in head-and-neck IMRT in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP)., Medical & biological engineering & computing, 45 (11), 1045-51 Abstract
  • Gutiérrez AN, Westerly DC, Tomé WA, Jaradat HA, Mackie TR, Bentzen SM, Khuntia D, Mehta MP (Oct 2007) Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost: a planning study., International journal of radiation oncology, biology, physics, 69 (2), 589-97 Abstract
  • Ghia A, Tomé WA, Thomas S, Cannon G, Khuntia D, Kuo JS, Mehta MP (Jul 2007) Distribution of brain metastases in relation to the hippocampus: implications for neurocognitive functional preservation., International journal of radiation oncology, biology, physics, 68 (4), 971-7 Abstract
  • Cannon GM, Tomé WA, Robins HI, Howard SP (Jul 2007) Pulsed reduced dose-rate radiotherapy: case report : a novel re-treatment strategy in the management of recurrent glioblastoma multiforme., Journal of neuro-oncology, 83 (3), 307-11 Abstract
  • Ehler ED, Nelms BE, Tomé WA (Apr 2007) On the dose to a moving target while employing different IMRT delivery mechanisms., Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 83 (1), 49-56 Abstract
  • Tomé WA, Jaradat HA, Nelson IA, Ritter MA, Mehta MP (2007) Helical tomotherapy: image guidance and adaptive dose guidance., Frontiers of radiation therapy and oncology, 40, 162-78 Abstract
  • Gondi V, Bradley K, Mehta M, Howard A, Khuntia D, Ritter M, Tomé W (Jan 2007) Impact of hybrid fluorodeoxyglucose positron-emission tomography/computed tomography on radiotherapy planning in esophageal and non-small-cell lung cancer., International journal of radiation oncology, biology, physics, 67 (1), 187-95 Abstract
  • Tomé WA, Howard SP (Jan 2007) On the possible increase in local tumour control probability for gliomas exhibiting low dose hyper-radiosensitivity using a pulsed schedule., The British journal of radiology, 80 (949), 32-7 Abstract
  • Wagner TH, Meeks SL, Bova FJ, Friedman WA, Willoughby TR, Kupelian PA, Tome W (2007) Optical tracking technology in stereotactic radiation therapy., Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 32 (2), 111-20 Abstract
  • Orton NP, Jaradat HA, Tomé WA (Dec 2006) Clinical assessment of three-dimensional ultrasound prostate localization for external beam radiotherapy., Medical physics, 33 (12), 4710-7 Abstract
  • Kim Y, Tomé WA (Dec 2006) Risk-adaptive optimization: selective boosting of high-risk tumor subvolumes., International journal of radiation oncology, biology, physics, 66 (5), 1528-42 Abstract
  • Fenwick JD, Tomé WA, Soisson ET, Mehta MP, Rock Mackie T (Oct 2006) Tomotherapy and other innovative IMRT delivery systems., Seminars in radiation oncology, 16 (4), 199-208 Abstract
  • Welsh JS, Lock M, Harari PM, Tomé WA, Fowler J, Mackie TR, Ritter M, Kapatoes J, Forrest L, Chappell R, Paliwal B, Mehta MP (Oct 2006) Clinical implementation of adaptive helical tomotherapy: a unique approach to image-guided intensity modulated radiotherapy., Technology in cancer research & treatment, 5 (5), 465-79 Abstract
  • Siker ML, Tomé WA, Mehta MP (Sep 2006) Tumor volume changes on serial imaging with megavoltage CT for non-small-cell lung cancer during intensity-modulated radiotherapy: how reliable, consistent, and meaningful is the effect?, International journal of radiation oncology, biology, physics, 66 (1), 135-41 Abstract
  • Kim Y, Tomé WA, Bal M, McNutt TR, Spies L (May 2006) The impact of dental metal artifacts on head and neck IMRT dose distributions., Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 79 (2), 198-202 Abstract
  • Khuntia D, Jaradat H, Orton N, Tomé W, Mehta MP, Welsh JS (Mar 2006) Helical tomotherapy as a means of administering total or partial scalp irradiation: In regards to Bedford et al. (Int J Radiat Oncol Biol Phys 2005;62:1549-1558)., International journal of radiation oncology, biology, physics, 64 (4), 1288-9; author reply Abstract
  • Soisson ET, Tomé WA, Richards GM, Mehta MP (Mar 2006) Comparison of linac based fractionated stereotactic radiotherapy and tomotherapy treatment plans for skull-base tumors., Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 78 (3), 313-21 Abstract
  • Aoyama H, Westerly DC, Mackie TR, Olivera GH, Bentzen SM, Patel RR, Jaradat H, Tome WA, Ritter MA, Mehta MP (Mar 2006) Integral radiation dose to normal structures with conformal external beam radiation., International journal of radiation oncology, biology, physics, 64 (3), 962-7 Abstract
  • Hodge W, Tomé WA, Jaradat HA, Orton NP, Khuntia D, Traynor A, Weigel T, Mehta MP (2006) Feasibility report of image guided stereotactic body radiotherapy (IG-SBRT) with tomotherapy for early stage medically inoperable lung cancer using extreme hypofractionation., Acta oncologica (Stockholm, Sweden), 45 (7), 890-6 Abstract
  • Hong TS, Tomé WA, Jaradat H, Raisbeck BM, Ritter MA (2006) Pelvic nodal dose escalation with prostate hypofractionation using conformal avoidance defined (H-CAD) intensity modulated radiation therapy., Acta oncologica (Stockholm, Sweden), 45 (6), 717-27 Abstract
  • Tomé WA, Fenwick JD, Bentzen SM (2006) Does a local bystander effect necessitate a revision of TCP models that are based on observed clinical data?, Acta oncologica (Stockholm, Sweden), 45 (4), 406-11 Abstract
  • Welsh JS, Mehta MP, Mackie TR, Orton N, Jaradat H, Khuntia D, Tomé W (Dec 2005) Helical tomotherapy as a means of delivering scalp-sparing whole brain radiation therapy., Technology in cancer research & treatment, 4 (6), 661-2; author reply Abstract
  • Richards GM, Bradley KA, Tomé WA, Bentzen SM, Resnick DK, Mehta MP (Dec 2005) Linear accelerator radiosurgery for trigeminal neuralgia., Neurosurgery, 57 (6), 1193-200; discussion Abstract
  • Zhang T, Orton NP, Tomé WA (Nov 2005) On the automated definition of mobile target volumes from 4D-CT images for stereotactic body radiotherapy., Medical physics, 32 (11), 3493-502 Abstract
  • Manon RR, Jaradat H, Patel R, Zhang T, Fenwick J, Tome W, Fowler J, Paliwal B, Soisson E, Yuan Z, Mehta M (Sep 2005) Potential for radiation therapy technology innovations to permit dose escalation for non-small-cell lung cancer., Clinical lung cancer, 7 (2), 107-13 Abstract
  • Meeks SL, Tome WA, Willoughby TR, Kupelian PA, Wagner TH, Buatti JM, Bova FJ (Jul 2005) Optically guided patient positioning techniques, 15 (3), 192-201
  • Hong TS, Tome WA, Harari PM (May 2005) Intensity-modulated radiation therapy in the management of head and neck cancer, 17 (3), 231-5
  • Hong TS, Ritter MA, Tome WA, Harari PM (May 2005) Intensity-modulated radiation therapy: emerging cancer treatment technology, British Journal of Cancer, 92 (10), 1819-24
  • Fenwick JD, Tome WA, Kissick MW, Mackie TR, Modelling Simple Helically Delivered Dose Distributions., Physics in Medicine and Biology, 50(7), 1505-17, Apr 2005 Abstract
  • Welsh JS, Limmer JP, Howard SP, Diamond D, Harari PM, Tome W (Apr 2005) Precautions in the use of intensity-modulated radiation therapy, Technology in Cancer Research & Treatment, 4 (2), 203-10
  • Hong TS, Tome WA, Chappell RJ, Chinnaiyan P, Mehta MP, Harari PM, The Impact of Daily Setup Variations on Head-and-neck Intensity-modulated Radiation Therapy., International Journal of Radiation Oncology, Biology, Physics, 61(3), 779-88, Mar 2005 Abstract
  • Orton N, Jaradat H, Welsh J, Tomé W (2005) Total scalp irradiation using helical tomotherapy., Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 30 (3), 162-8 Abstract
  • Fowler JF, Tome WA, Fenwick JD, Mehta MP, A challenge to traditional radiation oncology, International Journal of Radiation Oncology, Biology, Physics, 60(4), 1241-56, Nov 2004 Abstract
  • Tome WA, Welsh J, Fowler JF, The effect of fraction time in intensity modulated radiotherapy: theoretical and experimental evaluation of an optimization problem (the real conclusions): in regard to Mu et al. Radiother, Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology., 72(1), 113-4; author reply, July 2004 Abstract
  • Fenwick JD, Tome WA, Jaradat HA, Hui SK, James JA, Balog JP, DeSouza CN, Lucas DB, Olivera GH, Mackie TR, Paliwal BR, Quality assurance of a helical tomotherapy machine, Physics in Medicine and Biology, 49(13), 2933-53, July 2004 Abstract
  • Tome WA, Fenwick JD, Analysis of radiation-induced liver disease using the Lyman NTCP model: In regard to Dawson et al. IJROBP 2002;53:810-821, International Journal of Radiation Oncology, Biology, Physics, 58(4), 1318-9; author reply, March 2004
  • Keller H, Tome W, Ritter MA, Mackie TR, Design of adaptive treatment margins for non-negligible measurement uncertainty: Application to ultrasound-guided prostate radiation therapy, Physics in Medicine and Biology, 49(1), 69-86, January 2004
  • Chinnaiyan P, Tome W, Patel R, Chappell R, Ritter M, 3D-Ultrasound Guided Radiation Therapy in the Post-Prostatectomy Setting, Technol Cancer Res Treat, 2(5), 455-8, October 2003 Abstract
  • Richardson SL, Tome WA, Orton NP, McNutt TR, Paliwal BR, IMRT delivery verification using a spiral phantom, Medical Physics, 30(9), 2553-8, September 2003 Abstract
  • Tome WA, Fowler JF, On the inclusion of proliferation in tumour control probability calculations for inhomogeneously irradiated tumours, Physics in Medicine and Biology, 48(18), N261-8, September 2003 Abstract
  • Patel RR, Orton N, Tome WA, Chappell R, Ritter MA, Rectal dose sparing with a balloon catheter and ultrasound localization in conformal radiation therapy for prostate cancer, 67(3), 285-94, June 2003
  • Mackie TR, Kapatoes J, Ruchala K, Lu W, Wu C, Olivera G, Forrest L, Tome WA, Welsh J, Jeraj R, Harari P, Reckwerdt P, Paliwal B, Ritter M, Keller H, Fowler J, Mehta M, Image guidance for precise conformal radiotherapy, International Journal of Radiation Oncology, Biology, Physics, 56(1), 89-105, May 2003
  • Stieber VW, Bourland JD, Tome WA, Mehta MP, Gentlemen (and Ladies), Choose your Weapons: Gamma Knife vs. Linear Accelerator Radiosurgery, Technol Cancer Res Treat, 2(2), 79-86, April 2003
  • Scrimger RA, Tome WA, Olivera GH, Reckwerdt PJ, Mehta MP, Fowler JF, Reduction in radiation dose to lung and other normal tissues using helical tomotherapy to treat lung cancer, in comparison to conventional field arrangements, 26(1), 70-8, February 2003
  • Jaradat HA, Tome WA, McNutt TR, Meyerand ME, On the incorporation of multi-modality image registration into the radiotherapy treatment planning process, Technol Cancer Res Treat, 2(1), 1-12, February 2003 Abstract
  • McNutt TR, Tome WA, A method of scaling the 3D electron pencil-beam dose calculation to obtain accurate monitor units for irregularly-shaped electron beams, 27(3), 209-13, 2002
  • Tome WA, Meeks SL, Orton NP, Bouchet LG, Bova FJ, Commissioning and quality assurance of an optically guided three-dimensional ultrasound target localization system for radiotherapy, Medical Physics, 29(8), 1781-8, Aug 2002 Abstract
  • Tome WA, Fowler JF, On cold spots in tumor subvolumes, Medical Physics, 29(7), 1590-8, July 2002 Abstract
  • Tome WA, Mehta MP, Meeks SL, Bautti JM, Fractionated stereotactic radiotherapy: A short review, Technol Cancer Res Treat, 1(3), 153-72, June 2002
  • Tome WA, Beam modeling for a convolution/superposition-based treatment planning system, 27(1), 11-9, Spring 2002
  • Tome WA, In stereotactic radiosurgery, implanted fiducials are superior to an external coordinate system. Against the proposition, 29(1), 101-2, January 2002
  • Tome WA, Meeks SL, McNutt TR, Buatti JM, Bova FJ, Friedman WA, Mehta M, Optically guided intensity modulated radiotherapy, 61(1), 33-44, October 2001
  • Miranpuri AS, Tome WA, Paliwal BR, Kesslering C, Mehta MP, Assessment of patient-independent intrinsic error for a noninvasive frame for fractionated stereotactic radiotherapy, International Journal of Cancer. Journal International Du Cancer, 96(5), 320-5, October 2001 Abstract
  • Li Z, Nalcacioglu IA, Ranka S, Sahni SK, Palta JR, Tome W, Kim S, An algorithm for automatic, computed-tomography-based source localization after prostate implant, Medical Physics, 28(7), 1410-5, July 2001 Abstract
  • Paliwal B, Tome W, Richardson S, Makie TR, A spiral phantom for IMRT and tomotherapy treatment delivery verification, Medical Physics, 27(11), 2503-7, November 2000 Abstract
  • Tome WA, Fowler JF, Selective boosting of tumor subvolumes, International Journal of Radiation Oncology, Biology, Physics, 48(2), 593-9, 2000 Abstract
  • Mehta MP, Tome WA, Olivera GH, Radiotherapy for brain tumors, Current Oncology Reports, 2(5), 438-44, September 2000 Abstract
  • Tome WA, Meeks SL, Buatti JM, Bova FJ, Friedman WA, Li Z, A high-precision system for conformal intracranial radiotherapy, International Journal of Radiation Oncology, Biology, Physics, 47(4), 1137-43, 2000 Abstract
  • Tome WA, Steeves RA, Paliwal BP, On the use of virtual simulation in radiotherapy of the intact breast, 1(2), 58-67, Spring 2000
  • Tomé W, Mehta M, Paliwal B, From roots to realizations-radiosurgery, ADVANCE for Administrators in Radiology and Radiation Oncology, 10(7), 45-50, 2000
  • Meeks SL, Bova FJ, Kim S, Tome WA, Buatti JM, Friedman, Dosimetric characteristics of a double-focused miniature multileaf collimator, Medical Physics, 26(5), 729-33, May 1999 Abstract
  • Sanghavi S,Skrupky R, Badie B, Robins I, Tomé W, Mehta M, Recurrent Malignant Glioma treated with Radiosurgery, Journal of Radiosurgery, 119-124, 1999
  • Wolfgang A Tomé (1998) Path Integrals on Group Manifolds: the Representation Independent Propagator for General Lie Groups (Hardcover), 1st edition, World Scientific Publishing Company, 213 pages, ISBN=9810233558
  • Tome WA, Palta JR, On the calculation of mean restricted collision stopping powers, Medical Physics, 25(5), 758-72, May 1998 Abstract
  • Tomé WA (1996) A representation independent propagator. II: Lie groups with square integral representations, Ann. Inst. Henri Poincare, Theor. Phys., 56, 175-222
  • Tomé WA (1995) A representation independent propagator. I: Compact Lie groups, Ann. Inst. Henri Poincare, Theor. Phys, 63, 1-40
  • Klauder JR, Tomé WA (1994) The universal propagator for group-related coherent states, Acta Phys. Polonica A, 85, 655-666
  • Tomé WA, and Klauder J, The universal propagator for spin [or SU(2)] coherents states, Math. Phys, 2893-2913, 1993
  • Klauder JR, Tomé WA (1992) The universal propagator for affine [or SU(1,1)] coherent states, Math. Phys, 33, 33
  • Tomé W, and Gudder S, The convergence of observables on quantum logics, 20, 417-434, 1990

Memberships

American Association of Physicists in Medicine
American College of Medical Physics
American Society for Therapeutic Radiology and Oncology
European Society for Therapeutic Radiology and Oncology

Honors and Awards

1996, ALPHA NU SIGMA National Nuclear Engineering Honor Society, University of Florida
1996, Full Member, SIGMA XI, The Scientific Research Society, University of Florida, Physics
1994, President's Recognition of Outstanding Students Award, University of Florida-Gainesville
1992-1995, Doctoral Fellow of the Studienstiftung des Deutschen Volkes
1991, Graduate Teaching Assistant of the Year Award, University of Florida-Gainesville, Physics
1989, PI MU EPSILON National Mathematical Honor Society, University of Denver
1989, PHI BETA DELTA International Scholar Honor Society, University of Denver
1986-1989, Fellow Studienstiftung des deutschen Volkes
1983-1986, Fellow Oskar Kalbfell Stiftung

Patents

Radiation therapy volume phantom using film, Patent Number: 6974254, 2005, Institution, United States of America.

Previous Positions

2003-2006, Associate Professor (CHS), University of Wisconsin-Madison, School of Medicine and Public Health, Human Oncology
1998-2003, Assistant Professor (CHS), University of Wisconsin-Madison, School of Medicine and Public Health, Human Oncology
1996-1998, Postdoctoral Associate, University of Florida, College of Medicine, Radiation Oncology Department
1995-1996, Assistant Researcher, University of Florida, College of Engineering, Physics and Radiation Oncology
1994-1995, Instructor, University of Florida, College of Liberal Arts and Sciences, Physics
1992-1993, Instructor, University of Florida, College of Liberal Arts and Sciences, Physics

Other Expertise

Quantization of Physical Systems moving on Group Manifolds
Path Integrals on Group Manifolds
Coherent States
Quantum Logics

Keywords

COS Keywords:

Biological Modeling, Brain Tumors, Medical Physics, Physics, Radiation Oncology, Radiotherapy.

Additional Terms:

Biomathematical Modeling, Brain Tumors, Fractionated Stereotactic Radiotherapy, Image Guided Therapy, Multimodality Imaging, Radiotherapy Physics, Stereotactic Radiosurgery.

Languages

(Reading, Writing, Speaking)

German: (Fluent, Fluent, Fluent)

Profile Details

Last Updated: 1/20/2008

COS Expertise ID #460465
Reference this profile directly: http://myprofile.cos.com/tome