Dr. Lawrence T. Reiter

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University of Tennessee
Health Science Center
Neurology
Assistant ProfessorAppointed: 2005
UTHSC
Pediatrics
Assistant ProfessorAppointed: 2006
University of Tennessee
Molecular Resource Center
Drosophila Transgenic Core
DirectorAppointed: 2006
University of Tennessee
Medical School
Neurology
Neurogenetics
DirectorAppointed: 2005
Professional Headshot of Lawrence T. Reiter

Mailing Address

855 Monroe Ave.
Room 431
Memphis, Tennessee 38163
United States

Contact Information

Phone: (901) 448-2635
Mobile: (619) 520-2529
lreiter@utmem.edu
http://curlyo.utmem.edu

Qualifications

Ph.D., Baylor College of Medicine, Cell and Molecular Biology, 1997.
B.S., University of Southern California, Molecular Biology, 1991.

Future Research

One of my long-term goals is to continue to develop my skills in informatics, human genetic disease mechanisms and basic science. My lab currently utilizes the model organism Drosophila melanogaster to investigate human genetic disease gene function. I am currently working on several projects to this end. The main focus of my research is to identify the targets of the human E3 ligase UBE3A. Mutations in this gene cause a mental retardation disorder known as Angelman syndrome and may also be resposible for some cases of autism. We are currently doing biochemistry as genetic screening using the Drosophila version of the UBE3A gene to identify these targets. I feel that the targets of UBE3A will play key roles in basic neuron functions like synaptic plasticity and that the misregulation of these targets by altered UBE3A levels can result in clinical manifestations ranging from autism to mental retardation.

Industrial Relevance

We have found that over 75% of known human disease associated genes have counterparts in Drosophila. Since Drosophila is a simple model organism that is ideal for doing genetic screening, it is our hope that we will be able to identify proteins which interact with these disease associated proteins. In this way we hope to quickly identify putative therapeutic targets for such diseases.

In 2002 Dr. Ethan Bier and I founded a small biotechnology company called Novascape sciences. The goal of Novascapesciences is to utilize the tools of Drosophila melanogaster to determine the eitiology of human disease. This project involves several patents, on which two I am a co-author.

Keywords

COS Keywords:

Anatomy, Ataxia, Autism, Biological Modeling, Biological Sciences, Genetics, Neurobiology, Neuroscience, Proteomics.

Additional Terms:

Genetic Models, Human Drosophila Disease, Proteomics.

Memberships

American Society of Human Genetics
Genetics Society of America

Honors and Awards

2006, Invited Speaker, Epigenetics and Neural Developmental Disorders
2005-2005, Co-chair, ASHG, Model organsims from yeast to humans (minus the mouse)
2003-2005, Postdoctoral Fellowship, Cure Autism Now Foundation, University of California, San Diego, Using Drosophila to study Angelman syndrome
2003, Postdoctoral Translational Award, ASHG, Best Postdoctoral Presentation
2002, Invited Speaker, ASHG, Using Drosophila to study Alzheimer's disease
2001, Scholarship, Bioinformatics Course, Cold Spring Harbor Laboratory, Bioinformatics
2000-2001, Postdoctoral Fellowship, Glaucoma Foundation, University of California, San Diego
1998, Outstanding Dissertation Award, Sigma Xi, Baylor College of Medicine, CMT1A Duplication/ HNPP Deletion
1998, Invited Speaker, ASHG, CMT1A Duplication/ HNPP Deletion
1997, Invited Speaker, FASEB, CMT1A
1997, Inivted Speaker, ASHG, CMT1A
1997-1998, Postdoctoral Fellowship, CMT Association, Baylor College of Medicine
1996, Claude W. Smith Fellowship Award, Baylor College of Medicine, Outstanding Graduate Student
1996, Boehringer Ingelheim Fellowship Award, Boehringer Ingelheim, Baylor College of Medicine, Travel Award
1996, Young Scientist Fellowship Award, Baylor College of Medicine

Previous Positions

1998-2005, Postdoctoral Fellow, University of California, San Diego, Biology
1997-1998, Postdoctoral Fellow CMT Association, Baylor College of Medicine, Medicine, Molecular and Human Genetics
1993-1997, Graduate Student, Baylor College of Medicine, Medicine, Molecular and Human Genetics

Funding Received

  • Cure Autism Now Foundation: Young Investigator Award, Jun 1, 2003 to Jun 1, 2005.
  • LeBonheur Children's Hospitial: Shainberg Neruoscience Fund, $80,000, 2007 to 2009.
  • Autism Speaks: Autism Speaks, Pilot Research Award, $120,000, 2007 to 2009.
  • Cure Autism Now: Pilot Research Award, $120,000, 2005 to 2007.

Publications

  • Reiter, L.T. (2007) Accentuate the Negative: Proteome Comparisons Using the Negative Proteome Database, Fly, 1 (3), In Press
  • Reiter, LT (2006) Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase., Human Molecular Genetics, 15 (18), 2825-35
  • Bier E, Reiter LT, Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins, Expert Opinion On Therapeutic Targets, 6(3), 387-99, June 2002 Abstract
  • Chien S, Reiter LT, Bier E, Gribskov M, Homophila: human disease gene cognates in Drosophila, Nucleic Acids Research, 30(1), 149-51, January 2002 Abstract
  • Reiter LT, Potocki L, Chien S, Gribskov M, Bier E, A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster, Genome Research, 11(6), 1114-25, June 2001 Abstract
  • Inoue K, Dewar K, Katsanis N, Reiter LT, Lander ES, Devon KL, Wyman DW, Lupski JR, Birren B, The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes, Genome Research, 11(6), 1018-33, June 2001 Abstract
  • Liehr T, Reiter LT, Lupski JR, Murakami T, Claussen U, Rautenstrauss B, Regional localization of 10 mariner transposon-like ESTs by means of FISH--evidence for a correlation with fragile sites, Mammalian Genome, 12(4), 326-8, April 2001 Abstract
  • Boerkoel CF, Inoue K, Reiter LT, Warner LE, Lupski JR, Molecular mechanisms for CMT1A duplication and HNPP deletion, Annals of the New York Academy of Sciences, 883, 22-35, 1999 Abstract
  • Reiter LT, Liehr T, Rautenstrauss B, Robertson HM, Lupski JR, Localization of mariner DNA transposons in the human genome by PRINS, Genome Research, 9(9), 839-43, September 1999 Abstract
  • Reiter LT, Hastings PJ, Nelis E, De Jonghe P, Van Broeckhoven C, Lupski JR, Human meiotic recombination products revealed by sequencing a hotspot for homologous strand exchange in multiple HNPP deletion patients, American Journal of Human Genetics, 62(5), 1023-33, May 1998 Abstract
  • Reiter LT, Murakami T, Koeuth T, Gibbs RA, Lupski JR, The human COX10 gene is disrupted during homologous recombination between the 24 kb proximal and distal CMT1A-REPs, Human Molecular Genetics, 6(9), 1595-603, September 1997 Abstract
  • Timmerman V, Rautenstrauss B, Reiter LT, Koeuth T, Lofgren A, Liehr T, Nelis E, Bathke KD, De Jonghe P, Grehl H, Martin JJ, Lupski JR, Van Broeckhoven C, Detection of the CMT1A/HNPP recombination hotspot in unrelated patients of European descent, Journal of Medical Genetics, 34(1), 43-9, January 1997 Abstract
  • Murakami T, Garcia CA, Reiter LT, Lupski JR, Charcot-Marie-Tooth disease and related inherited neuropathies, Medicine, 75(5), 233-50, September 1996 Abstract
  • Reiter LT, Murakami T, Koeuth T, Pentao L, Muzny DM, Gibbs RA, Lupski JR, A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element, Nature Genetics, 12(3), 288-97, March 1996 Abstract
  • Warner LE, Reiter LT, Murakami T, Lupski JR, Molecular mechanisms for Charcot-Marie-Tooth disease and related demyelinating peripheral neuropathies, Cold Spring Harbor Symposia On Quantitative Biology, 61, 659-71, 1996 Abstract
  • Hubar JS, Oeschger MP, Reiter LT, Effectiveness of radiographic film barrier envelopes, General Dentistry, 42(5), 406-8, 1994 Abstract

Profile Details

Last Verified: 7/20/2007

COS Expertise ID #1012474
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