Timothy W. Randolph

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Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Biostatistics and Biomathematics
Appointed: 2006
Professional Headshot of Timothy W. Randolph

Mailing Address

1100 Fairview Ave. N
M2-B500
Seattle, Washington 98109
United States

Contact Information

Phone: (206) 667-1079
trandolp@fhcrc.org

Qualifications

Ph.D., University of Oregon, Mathematics, 1990.
M.S., University of Oregon, Mathematics, 1984.
B.S., University of Puget Sound, Mathematics, 1982.

Expertise and Research Interests

Current research focuses on processing, classification and analysis of high-dimensional and/or functional data output from protein mass spectrometry, genetic assays and a variety of spectroscopies and imaging modalities. Other interests include methods for the analysis of networks used to describe gene and/or protein interactions. Additional experience includes lead statistician on biomarker validation studies within the NIH Early Detection Research Network.

Other Expertise

A career in mathematics began with a focus on functional analysis, spectral theory of operators and Fredholm theory. Teaching experience as an associate professor includes over 20 different course titles in undergraduate and graduate mathematics and advising for undergraduate and graduate students.

My original research evolved into the study of mathematical control theory, including the study of dynamics and stability of infinite-dimensional linear control systems (those described by system of partial differential and delay equations). An NIH career-transition award provided the opportunity to shift from a research emphasis in pure mathematics to the development of methods for analysis, computation and models of biological/biomedical data.

Keywords

COS Keywords:

Analysis and Functional Analysis, Biostatistics, Data Processing, Harmonic Analysis.

Additional Terms:

Bioinformatics, Functional Data Analysis, Mass Spectrometry.

Memberships

Society of Industrial and Applied Mathematics

Honors and Awards

1998, Dynamics and Control of Nonautonomous Systems, The Missouri Research Board
1994, Spectral Mapping Properties and Stabilization of Control Systems, The Missouri Research Board
1994-1995, Eigenproperties of Damped Dynamic Systems, The Missouri Research Board

Previous Positions

2002-2006, Senior Fellow, University of Washington, Biostatistics
1997, Visiting Associate Professor, University of Missouri-Columbia, Mathematics
1997-2003, Tenured Associate Professor, University of Missouri-Rolla, (Missouri University of Science and Technology)
1991-1996, Assistant Professor, University of Missouri-Rolla, Mathematics & Statistics
1984-1985, Instructor, University of the Pacific, Mathematics

Funding Received

  • R21 RR025787 (R. Gardner and T. Randolph, PI): Discovery of substrates of ubiquitin-protein ligases---the development of integrated experimental and computational methods, 2009 to 2011.
  • R01-GM082802, NIGMS, (co-investigator; P. Wang, PI): Statistical Methods for Integrative Analysis of Genomics and Proteomics Data, 2008 to 2013.
  • R01-CA126205, NCI, (T. Randolph, PI): Quantitative Methods for Spectral and Image Data in Proteomics Research, 2007 to 2012.
  • P01-CA053996, NCI (R. Prentice, PI): Statistical Methodologies, 2006 to 2011.
  • K25-GM067211 NIGMS, (T. Randolph, PI): Biomarkers in High-Dimensional Data From Genomics and Proteomics Technologies, 2002 to 2007.

Publications

  • X. Yu, T.W. Randolph, H. Tang, L. Hsu (2009) Detecting genomic aberrations using products in a multiscale analysis, Biometrics, In Press
  • J. Qiu, G. Choi, L. Li, H. Wang, S.J. Pitteri, S.R. Pereira-Faca, A.L. Krasnoselsky, T.W. Randolph, C. Edelstein, M. Barnett, M. Thornquist, G. Goodman, G. Omenn, D. Brenner, Z. Feng,S.M. Hanash (2008) Occurrence of autoantibodies to annexin 1, 14-3-3 theta and LAMR1 in pre-diagnostic lung cancer sera, Journal of Clinical Oncology, 5060--5066
  • D.F. McLerran, W.E. Grizzle, Z. Feng, W.L. Bigbee, L.L. Banez, L.H. Cazares, D.W. Chan, J. Diaz, E. Izbicka, J. Kagan, D.E. Malehorn, G. Malik, D. Oelschlager, A. Partin, T.W. Randolph, N. Rosenzweig; S. Srivastava, S. Srivastava, I.M. Thompson, M.D. Thor (2008) Analytical Validation of Serum Proteomic Profiling for Diagnosis of Prostate Cancer: Sources of Sample Bias, Clinical Chemistry, 54 (1), 44-52
  • D.F. McLerran, W.E. Grizzle, Z. Feng, I.M. Thompson, W.L. Bigbee, W.H. Cazares, D.W. Chan, J. Dahlgren, J. Diaz, J. Kagan, D.W. Lin, G. Malik, D. Oelschlager, A. Partin, T.W. Randolph, L. Sokoll, S. Srivastava, S. Srivastava, M. Thornquist, D. Troyer, G.L (2008) SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate Cancer, Clinical Chemistry, 54 (1), 53-60
  • D.F. McLerran, Z. Feng, O.J. Semmes, L. Cazares, T. Randolph (2008) Signal detection in high-resolution mass spectrometry data, Journal of Proteome Research, 7, 276-285
  • N. Sundararajan, D. Mao, S. Chan, T-W. Koo, X. Su, L. Sun, J. Zhang, K-b. Sung, M. Yamakawa, P. Gafken, T. Randolph, D. McLerran, Z. Feng, A. Berlin, M. Roth (2006) Ultra-sensitive detection and analysis of post-translational modifcations using surface enhanced Raman spectroscopy, Analytical Chemistry, 78 (11), 3543-3550
  • T. Randolph, Y. Yasui (2006) Multiscale processing of mass spectrometry data, Biometrics, 62, 589-597
  • T. Randolph (2006) Scale-based normalization of spectral data, Cancer Biomarkers, 2 (3-4), 135-144
  • Y. Yasui, T. Randolph, Z. Feng (2006) Profiling High-Dimensional Protein Expression Using MALDI-TOF Mass Spectrometry for Biomarker Discovery, Handbook of Statistics in Clinical Oncology, 2nd Edition, Boca Raton, FL, Taylor and Francis (bookchapter)
  • M. Bellew*, M. Coram*, M. Igra*, M. Fitzgibbon*, T. Randolph*, P. Wang*, J. Eng, C. Lin, D. Goodlett, R. Fang, A. Detter, H. Zhang, J. Whiteaker, A. Paulovich, M. McIntosh, { * Authors appear alphabetically} (2005) Informatics method for generating peptide arrays from high resolution LC-MS measurements from complex protein mixtures (msInspect), Bioinformatics, 22 (15), 1902-1909
  • T. Randolph, B. Mitchell, D. Mclerran, P. Lampe, Z. Feng (2005) Quantifying peptide signal in MALDI-TOF mass spectrometry data, Molecular and Cellular Proteomics, 4, 1990-1999
  • L. Hsu, S.G. Self, D. Grove, T. Randolph, K. Wang, J.J. Delrow, L. Loo, P. Porter (2005) Denoising array-based comparative genomic hybridization data using wavelets., Biostatistics, 6 (2), 211-226 Abstract
  • R. Padhi, S. N. Balakrishnan, T. Randolph (2001) Adaptive-critic based optimal neuro control synthesis for distributed parameter systems, Automatica, 37, 1223-1234
  • {Authors appear alphabetically} Y. Latushkin, T. Randolph, R. Schnaubelt (2001) Regularization and frequency-domain stability for well-posed systems, Mathematics of Control, Signals, and Systems, 37 (6), 1757-1793
  • {Authors appear alphabetically} S. Clark, Y. Latushkin, S. Montgomery-Smith, T. Randolph (2000) Stability radius and internal versus external stability in Banach spaces: an evolution semigroup approach, SIAM Journal of Control and Optimization, 38 (6), 1757-1793
  • {Authors appear alphabetically} Y. Latushkin, T. Randolph, R. Schnaubelt (1998) Mild solutions and exponential dichotomy of nonautonomous differential equations in Banach spaces, Journal of Dynamics Differential Equations, 10 (3), 489-510
  • T. Randolph, Y. Latushkin, S. Clark (1997) Evolution semigroups and stability of time-varying systems on Banach spaces, Proceedings of the IEEE Conf. on Decision and Control, 36, 3932-3937
  • D. Malone, D. Cronin, T. Randolph (1997) Eigenvalues and eigenvectors for damped gyroscopic systems, Transactions of the ASME Journal of Applied Mechanics, 64 (3), 710-712
  • {Authors appear alphabetically} Y. Latushkin, S. Montgomery-Smith, T. Randolph (1996) Evolutionary semigroups and dichotomy of linear skew-product flows on locally compact Banach spaces, Journal of Differential Equations, 121 (1), 73-116
  • S. Peres-da-Silva, D. Cronin, T. Randolph (1995) Eigenvalues and eigenvectors of nonclassically damped systems, Computers and Structures, 57 (5), 883-891
  • {Authors appear alphabetically} Y. Latushkin, T. Randolph (1995) Dichotomy of differential equations on Banach spaces and an algebra of weighted translation operators, Journal of Integral Equations and Operator Theory, 23, 472-500
  • T. Randolph, P. Patterson (1994) Semigroups affiliated with algebras of operators, Studia Mathematica, 108, 87-102
  • T. Randolph (1993) Spectral relationships in Banach algebras, Mathematical Proceedings of the Royal Irish Academy, 93 (1), 1--16

Profile Details

Last Verified: 8/29/2009

COS Expertise ID #1269883
Reference this profile directly: http://myprofile.cos.com/trandolp