Timothy W. Randolph

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Fred Hutchinson Cancer Research Center
Biostatistics and Biomathematics
Public Health Sciences
Appointed: 2006

Mailing Address

1100 Fairview Ave. N
M2-B500
Seattle, Washington 98109
United States

Contact Information

Phone: (206) 667-1079
trandolp@fhcrc.org

Qualifications

Ph.D., University of Oregon, Mathematics, 1990.
M.S., University of Oregon, Mathematics, 1984.
B.S., University of Puget Sound, Mathematics, 1982.

Expertise and Research Interests

Current research focuses on processing, classification and analysis of high-dimensional and/or functional data output from protein mass spectrometry, genetic assays and a variety of spectroscopies and imaging modalities. Other interests include methods for the analysis of networks used to describe gene and/or protein interactions. Additional experience includes lead statistician on biomarker validation studies within the NIH Early Detection Research Network.

Other Expertise

A career in mathematics began with a focus on functional analysis, spectral theory of operators and Fredholm theory. Teaching experience as an associate professor includes over 20 different course titles in undergraduate and graduate mathematics and advising for undergraduate and graduate students.

My original research evolved into the study of mathematical control theory, including the study of dynamics and stability of infinite-dimensional linear control systems (those described by system of partial differential and delay equations). An NIH career-transition award provided the opportunity to shift from a research emphasis in pure mathematics to the development of methods for analysis, computation and models of biological/biomedical data.

Keywords

COS Keywords:

Analysis and Functional Analysis, Biostatistics, Data Processing, Harmonic Analysis.

Memberships

Society of Industrial and Applied Mathematics

Honors and Awards

1998, Dynamics and Control of Nonautonomous Systems, The Missouri Research Board
1994, Spectral Mapping Properties and Stabilization of Control Systems, The Missouri Research Board
1994-1995, Eigenproperties of Damped Dynamic Systems, The Missouri Research Board

Previous Positions

2002-2006, Senior Fellow, University of Washington, Biostatistics
1997, Visiting Associate Professor, University of Missouri-Columbia
1997-2003, Tenured Associate Professor, University of Missouri-Rolla, Department of Mathematics and Statistics
1991-1996, Assistant Professor, University of Missouri-Rolla, Department of Mathematics and Statistics
1984-1985, Instructor, University of the Pacific, Mathematics

Funding Received

  • NIGMS, (P. Wang, PI): Statistical Methods for Integrative Analysis of Genomics and Proteomics Data, 2008 to 2013.
  • NCI, P01-CA053996 (R. Prentice, PI): Statistical Methodologies, 2006 to 2011.
  • NCI, (T. Randolph, PI): Quantitative Methods for Spectral and Image Data in Proteomics Research, 2006 to 2011.
  • NIGMS, (T. Randolph, PI): Biomarkers in High-Dimensional Data From Genomics and Proteomics Technologies, 2002 to 2007.

Publications

  • D.F. McLerran, Z. Feng, O.J. Semmes, L. Cazares, T. Randolph (2008) Signal detection in high-resolution mass spectrometry data, Journal of Proteome Research, 7, 276-285
  • D.F. McLerran, W.E. Grizzle, Z. Feng, I.M. Thompson, W.L. Bigbee, W.H. Cazares, D.W. Chan, J. Dahlgren, J. Diaz, J. Kagan, D.W. Lin, G. Malik, D. Oelschlager, A. Partin, T.W. Randolph, L. Sokoll, S. Srivastava, S. Srivastava, M. Thornquist, D. Troyer, G.L (2008) SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate Cancer, Clinical Chemistry, 54 (1), 53-60
  • D.F. McLerran, W.E. Grizzle, Z. Feng, W.L. Bigbee, L.L. Banez, L.H. Cazares, D.W. Chan, J. Diaz, E. Izbicka, J. Kagan, D.E. Malehorn, G. Malik, D. Oelschlager, A. Partin, T.W. Randolph, N. Rosenzweig; S. Srivastava, S. Srivastava, I.M. Thompson, M.D. Thor (2008) Analytical Validation of Serum Proteomic Profiling for Diagnosis of Prostate Cancer: Sources of Sample Bias, Clinical Chemistry, 54 (1), 44-52
  • T. Randolph (2006) Scale-based normalization of spectral data, Cancer Biomarkers, 2 (3-4), 135-144
  • T. Randolph, Y. Yasui (2006) Multiscale processing of mass spectrometry data, Biometrics, 62, 589-597
  • N. Sundararajan, D. Mao, S. Chan, T-W. Koo, X. Su, L. Sun, J. Zhang, K-b. Sung, M. Yamakawa, P. Gafken, T. Randolph, D. McLerran, Z. Feng, A. Berlin, M. Roth (2006) Ultra-sensitive detection and analysis of post-translational modifcations using surface enhanced Raman spectroscopy, Analytical Chemistry, 78 (11), 3543-3550
  • Y. Yasui, T. Randolph, Z. Feng (2006) Profiling High-Dimensional Protein Expression Using MALDI-TOF Mass Spectrometry for Biomarker Discovery, Handbook of Statistics in Clinical Oncology, 2nd Edition, Boca Raton, FL, Taylor and Francis (bookchapter)
  • T. Randolph, B. Mitchell, D. Mclerran, P. Lampe, Z. Feng (2005) Quantifying peptide signal in MALDI-TOF mass spectrometry data, Molecular and Cellular Proteomics, 4, 1990-1999
  • M. Bellew*, M. Coram*, M. Igra*, M. Fitzgibbon*, T. Randolph*, P. Wang, J. Eng, C. Lin, D. Goodlett, R. Fang, A. Detter, H. Zhang, J. Whiteaker, A. Paulovich, M. McIntosh, { * Authors appear alphabetically} (2005) Informatics method for generating peptide arrays from high resolution LC-MS measurements from complex protein mixtures (msInspect), Bioinformatics, 22 (15), 1902-1909
  • L. Hsu, S.G. Self, D. Grove, T. Randolph, K. Wang, J.J. Delrow, L. Loo, P. Porter (2005) Denoising array-based comparative genomic hybridization data using wavelets., Biostatistics, 6 (2), 211-226 Abstract
  • {Authors appear alphabetically} Y. Latushkin, T. Randolph, R. Schnaubelt (2001) Regularization and frequency-domain stability for well-posed systems, Mathematics of Control, Signals, and Systems, 37 (6), 1757-1793
  • R. Padhi, S. N. Balakrishnan, T. Randolph (2001) Adaptive-critic based optimal neuro control synthesis for distributed parameter systems, Automatica, 37, 1223-1234
  • {Authors appear alphabetically} S. Clark, Y. Latushkin, S. Montgomery-Smith, T. Randolph (2000) Stability radius and internal versus external stability in Banach spaces: an evolution semigroup approach, SIAM Journal of Control and Optimization, 38 (6), 1757-1793
  • {Authors appear alphabetically} Y. Latushkin, T. Randolph, R. Schnaubelt (1998) Mild solutions and exponential dichotomy of nonautonomous differential equations in Banach spaces, Journal of Dynamics Differential Equations, 10 (3), 489-510
  • D. Malone, D. Cronin, T. Randolph (1997) Eigenvalues and eigenvectors for damped gyroscopic systems, Transactions of the ASME Journal of Applied Mechanics, 64 (3), 710-712
  • T. Randolph, Y. Latushkin, S. Clark (1997) Evolution semigroups and stability of time-varying systems on Banach spaces, Proceedings of the IEEE Conf. on Decision and Control, 36, 3932-3937
  • {Authors appear alphabetically} Y. Latushkin, S. Montgomery-Smith, T. Randolph (1996) Evolutionary semigroups and dichotomy of linear skew-product flows on locally compact Banach spaces, Journal of Differential Equations, 121 (1), 73-116
  • {Authors appear alphabetically} Y. Latushkin, T. Randolph (1995) Dichotomy of differential equations on Banach spaces and an algebra of weighted translation operators, Journal of Integral Equations and Operator Theory, 23, 472-500
  • S. Peres-da-Silva, D. Cronin, T. Randolph (1995) Eigenvalues and eigenvectors of nonclassically damped systems, Computers and Structures, 57 (5), 883-891
  • T. Randolph, P. Patterson (1994) Semigroups affiliated with algebras of operators, Studia Mathematica, 108, 87-102
  • T. Randolph (1993) Spectral relationships in Banach algebras, Proceedings of the Royal Irish Academy, 93 (1), 1--16
  • J. Qiu, G. Choi, L. Li, H. Wang, S.J. Pitteri, S.R. Pereira-Faca, A.L. Krasnoselsky, T.W. Randolph, C. Edelstein, M. Barnett, M. Thornquist, G. Goodman, G. Omenn, D. Brenner, Z. Feng,S.M. Hanash, Occurrence of autoantibodies to annexin 1, 14-3-3 theta and LAMR1 in pre-diagnostic lung cancer sera, Journal of Clinical Oncology, In Press

Profile Details

Last Updated: 11/16/2008

COS Expertise ID #1269883
Reference this profile directly: http://myprofile.cos.com/trandolp