Fred Hutchinson Cancer Research Center Human Biology Division Senior Vice-PresidentAppointed: 2000 Fred Hutchinson Cancer Research Center Human Biology Division MemberAppointed: 2000 Fred Hutchinson Cancer Research Center Human Biology Division Division DirectorAppointed: 2000 University of Washington School of Medicine Genome Sciences Professor |  |
QualificationsPh.D., University of Leiden, Biology/Medicine, 1985. M.S., Purdue University, Biology, 1977. B.S., Purdue University, Wildlife Ecology, 1975. Expertise and Research InterestsThe Trask group studies large-scale facets of genome organization. Our work relies on use of molecular cytogenetics and computational genomics. Two experimental techniques, fluorescence in situ hybridization (FISH), a means of fluorescently tagging specific DNA sequences in chromosomes or nuclei, and flow cytometry, a technology for isolating specific chromosomes for molecular analyses based on their DNA content, are used often in our research.
The structure, function, and evolution of some of the more complex and variable regions of the human genome are under investigation. One project focuses on the subtelomeric regions of human chromosomes. These regions are a patchwork of sequence-blocks that are duplicated near the ends of multiple chromosomes. They exhibit remarkable polymorphism: the number and location of large blocks can vary among individuals. Because these segments can contain genes, the compositional variability of subtelomeric DNA may have phenotypic consequences. A combination of molecular and cytogenetic techniques is currently being used to unravel the structure, evolution, and function of these highly dynamic regions of the genome. We have also recently embarked on a study of the epigenetic characteristics of subtelomeres, with a particular focus on the molecular defect results in facioscapulohumeral dystrophy (FSHD) and the regulation of WASH, a subtelomere gene involved in actin organization.
We are also studying the large and complex duplications encompassing members of the olfactory receptor gene family. Members of this large gene family are distributed over 40 sites in the human genome, yet each sensory neuron expresses only one gene. In order to determine how the expressed repertoire of olfactory receptors has evolved and is regulated, we are analyzing the genomic organization and function of these genes in mouse and man.
Finally, we are applying new cytogenetic technologies to study the DNA lost and gained as cancer cells develop the capacity to metastasize. This work involves development of CGH arrays and collaboration with several oncology research groups. KeywordsCOS Keywords:Biotechnology, Cell Biology, Cytogenetics, DNA, Evolution, Flow Cytometry, Gene Expression, Gene Mapping, Gene Regulation, Genetic Diseases, Genetics, Genomics, Microscopy, Nucleic Acid Hybridization, Olfaction or Smell.Additional Terms:Cancer Genomics, Cell Biology, Chromosomes, DNA, Evolution, Fluorescence in Situ Hybridization, Gene, Gene Expression, Gene Regulation, Genetic Diseases, Genetics, Genomics, Human Variation, Imaging, Microscopy, Nuclear Structure, Olfactory Receptor Genes.Languages(Reading, Writing, Speaking)English: (Fluent, Fluent, Fluent) Dutch: (Fluent, Basic, Fluent) French: (Basic, None, None) Previous Positions2000-2000, Acting Chair,
University of Washington,
School of Medicine,
Molecular Biotechnology
1997-2006, Adjunct Professor,
University of Washington,
School of Medicine,
Bioengineering
1997-2001, Professor,
University of Washington,
School of Medicine,
Molecular Biotechnology
1997-2001, Adjunct Professor,
University of Washington,
College of Arts and Sciences,
Genetics
1993-1997, Adjunct Research Professor,
University of Washington,
School of Medicine,
Bioengineering
1993-1997, Research Professor,
University of Washington,
School of Medicine,
Molecular Biotechnology
1985-1992, Senior Biomedical Scientist,
Lawrence Livermore National Laboratory,
Biomedical Sciences
1983-1985, Research Scientist,
Radiobiological Institute TNO
1983-1983, Visiting Scientist,
Lawrence Livermore National Laboratory
1982-1983, Visiting Scientist,
Los Alamos National Laboratory
1979-1982, Research Scientist,
Radiobiological Institute TNO
1975-1975, Research Assistant,
Purdue University,
Science,
Biological Sciences
Publications- Young JM, Endicott RM, Parghi SS, Walker M, Kidd JM, Trask BJ (2008) Extensive copy-number variation of the human olfactory receptor gene family, AM J Hum Genet, In Press
- Holcomb IN, Grove DI, Kinnunen M, Friedman C, Gallaher I, Morgan TM, Sather CL, Delrow JJ, Nelson PS, Lange PH, Ellis WJ, True LD, Young JM, Hsu L, Trask BJ*, Vessella RL* (2008) Genomic alterations indicate tumor origin and varied metastatic potential of disseminated cells from protate cancer patients, Cancer Research, 68, 5599-5608
- Raphael BJ, Volik S, Yu P, Wu C, Huang G, Linardopoulou EV, Trask BJ, Waldman F, Costello J, Pienta K, Mills G, Bajsarowicz K, Kobayashi Y (2008) A sequence-based survey of the complex structural organization of tumor genomes, Genome Biology, 9 (R59)
- Linardopoulou EV, Parghi SS, Friedman C, Osborn GE, Parkhurst SM, Trask BJ (2007) Human subtelomeric WASH genes encode a new subclass of the WASP family, PLoS Genetics, 3 (237)
- Young JM, Trask BJ (2007) V2R gene families degenerated in primates, dog and cow, but expanded in opossum., Trends Genet, 23, 212-215
- Rudd MK, Friedman C, Parghi SS, Linardopoulou EV, Hsu L, Trask BJ (2007) Elevated rates of sister chromatid exchange at chromosome ends, PLoS Genet, 3(2):e32
- Young JM, Kambere M, Trask BJ, Lane RP, Divergent V1R repertoires in five species: amplification in rodents, decimation in primates, and a surprisingly small repertoire in dogs, Genome Res, 15, 231-240, 2005
- Linardopoulou EV, Williams EM, Fan Y, Friedman C, Young JM, Trask BJ (2005) Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication, Nature, 437, 94-100
- Rowen L, Williams E, Glusman G, Linardopoulou E, Friedman C, Ahearn ME, Seto J, Boysen C, Qin S, Wang K, Kaur A, Bloom S, Hood L, Trask BJ (2005) Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen., Mol Biol Evol, 22, 1712-1720
- Rat Genome Sequencing Project Consortium (including Trask BJ), Genome sequence of the brown Norway rat yields insights into mammalian evolution, Nature, 428, 493-521, 2004
- Lane RP, Young J, Newman T, Trask BJ, Species specificity in rodent pheromone receptor repertoires, Genome Res, 14, 603-608, 2004
- Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, Maner S, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, Reiner A, Gilliam TC, Trask B, Patterson N, Zetterberg A, Wigler M, Large-scale copy number polymorphism in the human genome, Science, 305, 525-528, 2004
- Loo LW, Grove DI, Williams EM, Neal CL, Cousens LA, Schubert EL, Holcomb IN, Massa HF, Glogovac J, Li CI, Malone KE, Daling JR, Delrow JJ, Trask BJ, Hsu L, Porter PL, Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes, Cancer Res, 64, 8541-8549, 2004
- Newman T, Trask BJ, Complex evolution of 7E olfactory receptor genes in segmental duplications, Genome Res, 13, 781-793, 2003
- Heilig R et al. (including Trask B), The DNA sequence and analysis of human chromosome 14, Nature, 421, 601-607, 2003
- Young JM, Shykind BM, Lane RP, Tonnes-Priddy L, Ross JA, Walker M, Williams EM, Trask BJ, Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels, Genome Biol, 4, R71, 2003
- Lane RP, Roach JC, Lee IY, Boysen C, Smit A, Trask BJ, Hood L, Genomic analysis of the olfactory receptor region of the mouse and human T-cell receptor alpha/delta loci, Genome Res, 12, 81-87, 2002
 - Young JM, Friedman C, Williams EM, Ross JA, Tonnes-Priddy L, Trask BJ, Different evolutionary processes shaped the mouse and human olfactory receptor gene families, Hum Mol Genet, 11, 535-546, 2002
 - Lane RP, Cutforth T, Axel R, Hood L, Trask BJ, Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion, Proc Natl Acad Sci U S A, 99, 291-296, 2002
 - Tanaka H, Tapscott SJ, Trask BJ, Yao MC, Short inverted repeats initiate gene amplification through the formation of a large DNA palindrome in mammalian cells, Proc Natl Acad Sci U S A, 99, 8772-8777, 2002
 - Mefford HC, Trask BJ, The complex structure and dynamic evolution of human subtelomeres, Nat Rev Genet, 3, 91-102, 2002
 - Gygi MP, Ferguson MD, Mefford HC, Lund KP, O'Day C, Zhou P, Friedman C, van den Engh G, Stolowitz ML, Trask BJ, Use of fluorescent sequence-specific polyamides to discriminate human chromosomes by microscopy and flow cytometry, Nucleic Acids Res, 30, 2790-2799, 2002
 - Trask BJ, Human cytogenetics: 46 chromosomes, 46 years and counting, Nat Rev Genet, 3, 769-778, 2002
 - Young JM, Trask BJ, The sense of smell: genomics of vertebrate odorant receptors, Hum Mol Genet, 11, 1153-1160, 2002
 - Sultana R, Yu CE, Yu J, Munson J, Chen D, Hua W, Estes A, Cortes F, de la Barra F, Yu D, Haider ST, Trask BJ, Green ED, Raskind WH, Disteche CM, Wijsman E, Dawson G, Storm DR, Schellenberg GD, Villacres EC, Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins, Genomics, 80, 129-134, 2002
- Fan Y, Linardopoulou E, Friedman C, Williams E, Trask BJ, Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes, Genome Res, 12, 1651-1662, 2002
- Fan Y, Newman T, Linardopoulou E, Trask BJ, Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions, Genome Res, 12, 1663-1672, 2002
- Lane RP, Cutforth T, Young J, Athanasiou M, Friedman C, Rowen L, Evans G, Axel R, Hood L, Trask BJ, Genomic analysis of orthologous mouse and human olfactory receptor loci indicates partial cluster stability yet minimal conservation beyond the coding sequence, Proc Natl Acad Sci U S A, 98, 7390-7395, 2001
- BAC Resource Consortium (60 authors, including Trask BJ), Integration of cytogenetic landmarks into the draft sequence of the human genome, Nature, 409, 953-958, 2001
- International Human Genome Mapping Consortium (113 authors, including Trask BJ), A physical map of the human genome, Science, 409, 934-941, 2001
- Olivier M et al. (55 authors, including Trask BJ), A high-resolution radiation hybrid map of the human genome draft sequence, Science, 291, 1298-1302, 2001
- Bailey JA, Yavor AM, Massa H, Trask BJ, Eichler EE, Segmental duplications: organization and impact within the current Human Genome Project assembly, Genome Res, 11, 1-13, 2001
- Mefford HC, Linardopoulou E, Coil D, van den Engh G, Trask BJ, Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple Interactions between non-homologous chromosomes, Hum Mol Genet, 10, 2363-2372, 2001
 - Linardopoulou E, Mefford HC, Nguyen O, Friedman C, van den Engh G, Farwell DG, Coltrera M, Trask BJ, Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location, Hum Mol Genet, 10, 2373-2383, 2001
 - Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L, Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human jagged2 (JAG2) gene, Genomics, 63, 133-138, 2000
 - Sachs RK, Hlatky LR, Trask BJ, Radiation-produced chromosome aberrations: colourful clues, Trends Genet, 16, 143-146, 2000
 - Lin B, White JT, Ferguson C, Bumgarner R, Friedman C, Trask B, Ellis W, Lange P, Hood L, Nelson PS, PART-1: a novel human prostate-specific, androgen-regulated gene that maps to chromosome 5q12, Cancer Res, 60, 858-860, 2000
- Singer MJ, Mesner LD, Friedman C, Trask BJ, Hamlin JL, Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks, Proc Natl Acad Sci U S A, 97, 7921-7926, 2000
- Siegel AF, van den Engh G, Hood L, Trask BJ, Roach J, Modeling the feasibility of whole genome shotgun sequencing using a pairwise end strategy, Genomics, 68, 247-252, 2000
- Giorgi D, Friedman C, Trask BJ, Rouquier S, Characterization of nonfunctional V1R-like pheromone receptor sequences in human, Genome Res, 10, 1979-1985, 2000
 - Yokota H, Fung K, Trask BJ, van den Engh G, Sarikaya M, Aebersold R, Sharp DNA bends as landmarks of protein-binding sites on straightened DNA, Anal Chem, 71, 1663-1667, 1999
 - Katz SG, Schneider SS, Bartuski A, Trask BJ, Massa H, Overhauser J, Lalande M, Lansdorp PM, Silverman GA, An 18q-syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA, Hum Mol Genet, 8, 87-92, 1999
 - Brand-Arpon V, Rouquier S, Massa H, de Jong PJ, Ferraz C, Ioannou PA, Demaille JG, Trask BJ, Giorgi D, A genomic region encompassing a cluster of olfactory receptor ggenomic region encompassing a cluster of olfactory receptor genes and a myosin light chain kinase (MYLK) gene is duplicated on human chromosome regions 3q13-q21 and 3p13, Genomics, 56, 98-110, 1999
 - DeSilva U, Massa H, Trask BJ, Green ED, Comparative mapping of the region of human chromosome 7 deleted in Williams Syndrome, Genome Res, 9, 428-436, 1999
 - Siegel AF, Trask BJ, Roach J, Mahairas GG, Hood L, van den Engh G, Analysis of sequence-tagged conector (STC) strategies for DNA sequencing, Genomics, 9, 297-307, 1999
- Vissinga CS, Yeo TC, Woessner J, Massa HF, Wilson RK, Trask BJ, Concannon P, Identification and characterization of a mouse homologue of the gene mutated in Nijmegen breakage, Cytogenet Cell Genet, 87, 80-84, 1999
- Roach JC, Siegel AF, van den Engh G, Trask BJ, Hood L, Gaps in the Human Genome Project, Nature, 401, 843-845, 1999
- Sharma V, Poorkaj P, Hisama F, Bonnycastle L, Yu CE, Massa H, Trask B, Clancy KP, Patterson D, Weissman SM, Schellenberg GD, An expression map from human chromosome 14q24.3, Genomics, 47, 314-318, 1998
 - Yokota H, Nickerson DA, Trask BJ, van den Engh G, Hirst M, Sadowski I, Aebersold R, Mapping a protein-binding site on straightened DNA by atomic force microscopy, Anal Biochem, 264, 158-164, 1998
 - Rouquier S, Friedman C, Delettre C, van den Engh G, Blancher A, Crouau-Roy B, Trask B J, Giorgi D, A gene recently inactivated in human defines a new olfactory receptor family in mammals, Hum Mol Genet, 7, 1337-1345, 1998
 - La Spada AR, Peterson KR, Meadows SA, McClain ME, Jeng G, Chmelar RS, Haugen HA, Chen K, Singer MJ, Moore D,Trask BJ, Fischbeck KH, Clegg CH, McKnight GS, Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability, Hum Mol Genet, 7, 959-967, 1998
 - Chaudhary PM, Ferguson C, Nguyen V, Nguyen O, Massa HF, Eby M, Jasmin A, Trask BJ, Hood L, Nelson PS, Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans, Blood, 91, 4020-4027, 1998
 - Li L, Huang GM, Banta AB, Deng Y, Smith T, Dong P, Friedman C, Chen L, Trask BJ, Spies T, Rowen L, Hood L, Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene, Genomics, 51, 45-58, 1998
 - Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D, Distribution of olfactory receptor genes in the human genome, Nat Genet, 18, 243-250, 1998
 - Thai TH, Du F, Tsan JT, Jin Y, Phung A, Spillman MA, Massa HF, Muller CY, Ashfaq R, Mathis JM, Miller DS, Trask BJ, Baer R, Bowcock AM, Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers, Hum Mol Genet, 7, 195-202, 1998
 - Li L, Milner LA, Deng Y, Iwata M, Banta A, Graf L, Marcovina S, Friedman C, Trask BJ, Hood L, Torok-Storb B, The human homolog of rat jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with notch1, Immunity, 8, 43-55, 1998
 - Trask BJ, Friedman C, Martin-Gallardo A, Rowen L, Akinbami C, Blankenship J, Collins C, Giorgi D, Iadonato S, Johnson F, Kuo WL, Massa H, Morrish T, Naylor S, Nguyen OT, Rouquier S, Smith T, Wong DJ, Youngblom J, van den Engh G, Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes, Hum Mol Genet, 7, 13-26, 1998
 - Meng X, Lu X, Li Z, Green ED, Massa H, Trask BJ, Morris CA, Keating MT, Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes, Hum Genet, 103, 590-599, 1998
 - Trask BJ, Massa H, Brand-Arpon V, Chan K, Friedman C, Nguyen OT, Eichler E, van den Engh G, Rouquier S, Shizuya H, Giorgi D, Large multi-chromosomal duplications encompass many members of the olfactory receptor gene family in the human genome, Hum Mol Genet, 7, 2007-2020, 1998
 - Bartuski AJ, Kamachi Y, Schick C, Massa H, Trask BJ, Silverman GA, A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases, Genomics, 54, 297-306, 1998
 - Geier SJ, Algate PA, Carlberg K, Flowers D, Friedman C, Trask B, Rohrschneider LR, The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood, Blood, 89, 1876-1885, 1997
 - Han DK, Chaudhary PM, Wright ME, Friedman C, Trask BJ, Riedel RT, Baskin DG, Schwartz SM, Hood L, MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell dinitiates cell death, Proc Natl Acad Sci U S A, 94, 11333-11338, 1997
 - Yokota H, Singer MJ, van den Engh GJ, Trask BJ, Regional differences in the compaction of chromatin in human G0/G1 interphase nuclei, Chromosome Res, 5, 157-166, 1997
 - Mefford H, van den Engh G, Friedman C, Trask BJ, Analysis of the variation in chromosome size among diverse human populations by bivariate flow karyotyping, Hum Genet, 100, 138-144, 1997
 - Yokota H, Johnson F, Lu H, Robinson RM, Belu AM, Garrison MD, Ratner BD, Trask BJ, Miller DL, A new method for straightening DNA molecules for optical restriction mapping, Nucleic Acids Res, 25, 1064-1070, 1997
 - Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, Qi M, Trask BJ, Kuo WL, Cochran J, Costa T, Pierpont ME, Rand EB, Piccoli DA, Hood L, Spinner NB, Alagille syndrome is caused by mutations in human jagged1, which encodes a ligand for notch1, Nat Genet, 16, 243-251, 1997
 - Lanyi A, Li B, Li S, Talmadge CB, Brichacek B, Davis JR, Kozel BA, Trask B, van den Engh G, Uzvolgyi E, Stanbridge EJ, Nelson DL, Chinault C, Heslop H, Gross TG, Seemayer TA, Klein G, Purtilo DT, Sumegi J, A yeast artificial chromosome (YAC) contig encompassing the critical region of the X-linked lymphoproliferative disease (XLP) locus, Genomics, 39, 55-65, 1997
 - Gorski JL, Bialecki MD, McDonald MT, Massa HF, Trask BJ, Burright EN, Cosmids map two incontinentia pigmenti type 1 (IP1) translocation breakpoints to a 180-kb region within a 1.2-Mb YAC contig, Genomics, 35, 338-345, 1996
 - Yu CE, Oshima J, Hisama FM, Matthews S, Trask BJ, Schellenberg GD, A YAC, P1, and cosmid contig and 17 new polymorphic markers for the werner syndrome region At 8p12-p21, Genomics, 35, 431-440, 1996
 - Trask BJ, Mefford H, van den Engh G, Massa HF, Juyal RC, Potocki L, Finucane B, Abuelo DN, Witt DR, Magenis E, Baldini A, Greenberg F, Lupski JR, Patel PI, Quantification by flow cytometry of chromosome-17 deletions in Smith-Magenis syndrome patients, Hum Genet, 98, 710-718, 1996
 - Liao X, Ma C, Trask B, Massa H, Gilbert DJ, Staudt LM, Jenkins NA, Copeland NG, LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12, Mamm Genome, 7, 467-468, 1996
 - Ignatius J, Knuutila S, Scherer SW, Trask B, Kere J, Split hand/split foot malformation, deafness, and mental retardation with a complex cytogenetic rearrangement involving 7q21.3, J Med Genet, 33, 507-510, 1996
 - Sachs RK, van den Engh G, Trask B, Yokota H, Hearst JE, A random-walk/giant-loop model for interphase chromosomes, Proc Natl Acad Sci U S A, 92, 2710-2714, 1995
 - Wilson AC, Parrish JE, Massa HF, Nelson DL, Trask BJ, Herr W, The gene encoding the VP16-accessory protein HCF (HCFC1) resides in human Xq28 and is highly expressed in fetal tissues and the adult kidney, Genomics, 25, 462-468, 1995
 - Bryson GL, Massa H, Trask BJ, Van Etten RL, Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1, Genomics, 30, 133-140, 1995
 - Yokota H, van den Engh G, Mostert M, Trask BJ, Treatment of cells with alkaline borate buffer extends the capability of interphase FISH mapping, Genomics, 25, 485-491, 1995
 - Hui SM, Trask B, van den Engh G, Bartuski AJ, Smith A, Flint A, Lalande M, Silverman GA, Analysis of randomly amplified flow-sorted chromosomes using the polymerase chain reaction, Genomics, 26, 364-371, 1995
 - Pietenpol JA, Bohlander SK, Sato Y, Papadopoulos N, Liu B, Friedman C, Trask BJ, Roberts JM, Kinzler KW, Rowley JD, et al., Assignment of the human P27Kip1 gene to 12p13 and its analysis in leukemias, Cancer Res, 55, 1206-1210, 1995
 - Rouquier S, Trask BJ, Taviaux S, van den Engh G, Diriong S, Lennon GG, Giorgi D, Direct selection of CDNAs using whole chromosomes, Nucleic Acids Res, 23, 4415-4420, 1995
 - Juyal RC, Greenberg F, Mengden GA, Lupski JR, Trask BJ, van den Engh G, Lindsay EA, Christy H, Chen KS, Baldini A, et al, Smith-Magenis syndrome deletion: a case with equivocal cytogenetic findings resolved by fluorescence in situ hybridization, Am J Med Genet, 58, 286-291, 1995
 - Silverman GA, Schneider SS, Massa HF, Flint A, Lalande M, Leonard JC, Overhauser J, van den Engh G, Trask BJ, The 18q-syndrome: analysis of chromosomes by bivariate flow karyotyping and the PCR reveals a successive set of deletion breakpoints within 18q21.2-q22.2, Am J Hum Genet, 56, 926-937, 1995
 - Yokota H, van den Engh G, Hearst JE, Sachs RK, Trask BJ, Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus, J Cell Biol, 130, 1239-1249, 1995
 - Martin-Gallardo A, Lamerdin J, Sopapan P, Friedman C, Fertitta AL, Garcia E, Carrano A, Negorev D, Macina RA, Trask BJ, Molecular analysis of a novel subtelomeric repeat with polymorphic chromosomal distribution, Cytogenet Cell Genet, 71, 289-95, 1995
 - Scherer SW, Poorkaj P, Massa H, Soder S, Allen T, Nunes M, Geshuri D, Wong E, Belloni E, Little S, Zhou L, Becher D, Kere J, Ignatius J, Niikawa N, Fukushima Y, Hasegawa T, Weissenbach J, Boncinelli E, Trask BJ, Tsui LC, Evans JP, Physical mapping of the split hand/split foot locus on chromosome 7 and implication in syndromic ectrodactyly, Hum Mol Genet, 3, 1345-1354, 1994
 - Green ED, Idol JR, Mohr-Tidwell RM, Braden VV, Peluso DC, Fulton RS, Massa HF, Magness CL, Wilson AM, Kimura J, Weissenbach J, Trask BJ, Integration of physical, genetic and cytogenetic maps of human chromosome 7: isolation and analysis of yeast artificial chromosome clones for 117 mapped genetic markers, Hum Mol Genet, 3, 489-501, 1994
 - Bonnycastle LL, Yu CE, Hunt CR, Trask BJ, Clancy KP, Weber JL, Patterson D, Schellenberg GD, Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2), Genomics, 23, 85-93, 1994
 - Trask BJ, Allen S, Massa H, Fertitta A, Sachs R, van den Engh G, Wu M, Studies of metaphase and interphase chromosomes using fluorescence in situ hybridization, Cold Spring Harb Symp Quant Biol, 58, 767-775, 1993
 - Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A, et al., Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers, Genomics, 15, 133-145, 1993
 - Gurrieri F, Trask BJ, van den Engh G, Krauss CM, Schinzel A, Pettenati MJ, Schindler D, Dietz-Band J, Vergnaud G, Scherer SW, et al., Physical mapping of the holoprosencephaly critical region on chromosome 7q36, Nat Genet, 3, 247-251, 1993
 - Rouquier S, Giorgi D, Trask B, Bergmann A, Phillips MS, MacLennan DH, de Jong P, A cosmid and yeast artificial chromosome contig containing the complete ryanodine receptor (RYR1) gene, Genomics, 17, 330-340, 1993
 - Roa BB, Garcia CA, Pentao L, Killian JM, Trask BJ, Suter U, Snipes GJ, Ortiz-Lopez R, Shooter EM, Patel PI, et al., Evidence for a recessive PMP22 point mutation in Charcot-Marie-Tooth disease type 1A, Nat Genet, 5(2), 189-194, 1993
 - Pasteris NG, Trask BJ, Sheldon S, Gorski JL, Discordant phenotype of two overlapping deletions involving the PAX3 gene in chromosome 2q35, Hum Mol Genet, 2, 953-959, 1993
 - Ma C, Martin S, Trask B, Hamlin JL, Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in chinese hamster cells, Genes Dev, 7, 605-620, 1993
 - Malo D, Gros P, Bergmann A, Trask B, Mohrenweiser HW, Canfield VA, Levenson R, Genes encoding the H,K-ATPase alpha and Na,K-ATPase alpha 3 subunits are linked on mouse chromosome 7 and human chromosome 19, Mamm Genome, 4, 644-649, 1993
 - Tynan K, Olsen A, Trask B, de Jong P, Thompson J, Zimmermann W, Carrano A, Mohrenweiser H, Assembly and analysis of cosmid contigs in the CEA-gene family region of human chromosome 19, Nucleic Acids Res, 20, 1629-1636, 1992
 - Yen RW, Vertino PM, Nelkin BD, Yu JJ, el-Deiry W, Cumaraswamy A, Lennon GG, Trask BJ, Celano P, Baylin SB, Isolation and characterization of the CDNA encoding human DNA methyltransferase, Nucleic Acids Res, 20, 2287-2291, 1992
 - van den Engh G, Sachs R, Trask BJ, Estimating genomic distance from DNA sequence location in cell nuclei by a random walk model, Science, 257, 1410-1412, 1992
 - Barnes DE, Kodama K, Tynan K, Trask BJ, Christensen M, De Jong PJ, Spurr NK, Lindahl T, Mohrenweiser HW, Assignment of the gene encoding DNA ligase I to human chromosome 19q13.2-13.3, Genomics, 12, 164-166, 1992
 - Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al., Evolution of the mammalian G protein alpha subunit multigene family, Nat Genet, 1, 85-91, 1992
 - Trask BJ, Massa HF, Burmeister M, Fluorescence in situ hybridization establishes the order Cen-DXS28(C7)-DXS67(B24)-DXS68(L1)-tel in human chromosome Xp21.3, Genomics, 13, 455-457, 1992
 - Patel PI, Roa BB, Welcher AA, Schoener-Scott R, Trask BJ, Pentao L, Snipes GJ, Garcia CA, Francke U, Shooter EM, et al., The gene for the peripheral myelin protein PMP-22 Is a candidate for Charcot-Marie-Tooth disease type 1A, Nat Genet, 1, 159-165, 1992
 - Guzzetta V, Franco B, Trask BJ, Zhang H, Saucedo-Cardenas O, Montes de Oca-Luna R, Greenberg F, Chinault AC, Lupski JR, Patel PI, Somatic cell hybrids, sequence-tagged sites, simple repeat polymorphisms, and yeast artificial chromosomes for physical and genetic mapping of proximal 17p, Genomics, 13, 551-559, 1992
 - Samson F, de Jong PJ, Trask BJ, Koza-Taylor P, Speer MC, Potter T, Roses AD, Gilbert JR, Assignment of the human slow skeletal troponin T gene to 19q13.4 using somatic cell hybrids and fluorescence in situ hybridization analysis, Genomics, 13, 1374-1375, 1992
 - Trask B, Christensen M, Fertitta A, Bergmann A, Ashworth L, Branscomb E, Carrano A, Van Den Engh G, Fluorescence in situ hybridization mapping of human chromosome 19: mapping and verification of cosmid contigs formed by random restriction enzyme fingerprinting, Genomics, 14, 162-167, 1992
 - McCabe ER, Towbin JA, van den Engh G, Trask BJ, Xp21 contiguous gene syndromes: deletion quantitation with bivariate flow karyotyping allows mapping of patient breakpoints, Am J Hum Genet, 51, 1277-1285, 1992
 - Brandriff BF, Gordon LA, Tynan KT, Olsen AS, Mohrenweiser HW, Fertitta A, Carrano AV, Trask BJ, Order and genomic distances among members of the carcinoembryonic antigen (CEA) gene family determined by fluorescence in situ hybridization, Genomics, 12, 773-779, 1992
 - Hendricks-Taylor LR, Bachinski LL, Siciliano MJ, Fertitta A, Trask B, de Jong PJ, Ledbetter DH, Darlington GJ, The CCAAT/enhancer binding protein (C/EBP Alpha) gene (CEBPA) maps to human chromosome 19q13.1 and the related nuclear factor NF-IL6 (C/EBP Beta) gene (CEBPB) maps to human chromosome 20q13.1, Genomics, 14, 12-17, 1992
 - Lupski JR, de Oca-Luna RM, Slaugenhaupt S, Pentao L, Guzzetta V, Trask BJ, Saucedo-Cardenas O, Barker DF, Killian JM, Garcia CA, et al., DNA duplication associated with Charcot-Marie-Tooth disease type 1A, Cell, 66, 219-232, 1991
 - Brandriff BF, Gordon LA, Trask BJ, DNA sequence mapping by fluorescence in situ hybridization, Environ Mol Mutagen, 18, 259-262, 1991
 - Trask BJ, DNA sequence localization in metaphase and interphase cells by fluorescence in situ hybridization, Methods Cell Biol, 35, 3-35, 1991
 - Trask BJ, Massa H, Kenwrick S, Gitschier J, Mapping of human chromosome Xq28 by two-color fluorescence in situ hybridization of DNA sequences to interphase cell nuclei, Am J Hum Genet, 48, 1-15, 1991
 - Trask BJ, van den Engh G, Christensen M, Massa HF, Gray JW, Van Dilla M, Characterization of somatic cell hybrids by bivariate flow karyotyping and fluorescence in situ hybridization, Somat Cell Mol Genet, 17, 117-136, 1991
 - Brandriff B, Gordon L, Trask B, A new system for high-resolution DNA sequence mapping interphase pronuclei, Genomics, 10, 75-82, 1991
 - Trask BJ, Fluorescence in situ hybridization: applications in cytogenetics and gene mapping, Trends Genet, 7, 149-154, 1991
 - Trask BJ, Gene mapping by in situ hybridization, Curr Opin Genet Dev, 1, 82-87, 1991
 - Franco B, Lai LW, Patterson D, Ledbetter DH, Trask BJ, van den Engh G, Iannaccone S, Frances S, Patel PI, Lupski JR, Molecular characterization of a patient With Del(1)(q23-q25), Hum Genet, 87, 269-277, 1991
 - Kwiatkowski TJ Jr, Beaudet AL, Trask BJ, Zoghbi HY, Linkage mapping and fluorescence in situ hybridization of TCTE1 on human chromosome 6p: analysis of dinucleotide polymorphisms on native gels, Genomics, 10, 921-926, 1991
 - van den Engh G, Hanson D, Trask B, A computer program for analyzing bivariate flow karyotypes, Cytometry, 11, 173-183, 1990
 - Trask B, van den Engh G, Nussbaum R, Schwartz C, Gray J, Quantification of the DNA content of structurally abnormal X Chromosomes and X chromosome aneuploidy using high resolution bivariate flow karyotyping, Cytometry, 11, 184-195, 1990
 - Gray JW, Kuo WL, Liang J, Pinkel D, van den Engh G, Trask B, Tkachuk D, Waldman F, Westbrook C, Analytical approaches to detection and characterization of disease-linked chromosome aberrations, Bone Marrow Transplantation, 6 (Suppl 1), 14-19, 1990
 - Trask B, van den Engh G, Chromosome and nuclei isolation with the MgSO4 procedure, Methods Cell Biol, 33, 363-367, 1990
 - Trask B, Pinkel D, Fluorescence in situ hybridization with DNA probes, Methods Cell Biol, 33, 383-400, 1990

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