Dr. James Edward Trosko

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Michigan State University
College of Human Medicine
Pediatrics & Human Development
ProfessorAppointed: 1966
Professional Headshot of James Edward Trosko

Mailing Address

Dept. of Pediatrics and Human Development
246 National Food Safety and Toxicolgy Building
Michigan State University
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 432-3100, ext. 188
Fax: (517) 432-6340
james.trosko@ht.msu.edu

Qualifications

Ph.D., Michigan State University, Radiation Genetics, 1963.
M.S., Michigan State University, Genetics, 1962.
B.A. (summa cum laude), Central Michigan University, Chemistry, Biology, 1960.

Expertise and Research Interests

My initial research involved the study of radiation-induced mammalian mutagenesis. This led to the discovery of deoxyribonucleic acid (DNA) repair in normal human cells and the lack of DNA repair and increased mutagenesis in the cancer-prone xeroderma pigmentosum syndrome. Later work with the tumor promoter, phorbolester, I discovered that the inhibition by tumor-promoting chemicals, oncogenes and growth factors were related to the mechanism of tumor promotion by their shared ability to modulate gap junction function. We then developed several in vitro assays to detect chemical modulators of gap junctional intercellular communication (GJIC) (e.g., metabolic cooperation assays; fluorescent recovery after photobleaching; scrape loading dye transfer, etc.) Later we found that modulation of GJIC was related to chemical induced teratogenesis, reproductive dysfunction and neurotoxicity. Most recently, we have demonstrated that normal human epithelial stem cells could be isolated from kidney tissues and breast tissues. In addition, anti-tumor chemicals, as well as tumor suppressor genes appear to up-regulate GJIC in a manner opposite to tumor promoters and oncogenes.We have recently discovered biomarkers for adult human stem cells and have provided the strongest evidence for the "stem cell theory" of cancer.

Other Expertise

Academic Experience:

Consultant to National Science Foundation; National Cancer Institute; Environmental Protection Agency, National
Institute of Environmental Health Sciences; Consultant to the Radiation Effects Research Foundation-RERF, Hiroshima, Japan;Scientific Advisor to the Princess Chulabhorn research Institute, Bangkok, Thailand.

Consultant to State of Michigan on genetic and environmental pollution matters

Consultant to Bristol-Myers-Squibb Pharmaceutic Company
Career Development Award
National Cancer Institute, 1972
Senior Scientist Award, Sigma Xi Society, 1985
Searle Award, United Kingdom Environment Mutagen Society, 1979
Fellow, TheAcademy of Toxicological Sciences, 1988

Business Experience:
Consultant to the Meridian Instruments Company

Consultant to National Cancer Institute ( Chem/Path Study Section)
Scientific Consultant to The College of Veterinary Medicine, Seoul National University;Scientific Consultant to The National Institute of Environmental Health- Tokyo, Japan; Consultant to the Princess Chulabhorn Research Institute-Bangkok, Thailand.

Scientific Adviser to the Radiation Effects Research Foundation-RERF ( 2004-2006)

Scientific Consultant to Medical Teachers Trainers College, Tokyo, Japan

Scientific reviewer for Cancer Research, Carcinogenesis, Cancer Letters, In Vitro Toxicology, Pharmacol. Toxicology, Toxicolog. Sci. ,Tox Appl. Pharm, Proc Natl. Acad Sci. USA, Molec. Carcinogenesis, J. Carcinogenesis, etc.

Future Research

1. Isolation of adult human stem cells based on our discovery of two molecular markers for all adult stem cells
2. Development of in vitro assay, using our adult human stem cells to screen for new chemo-preventive and chemotherapeutic drugs
3. Development of an in vitro assay to detect potential toxins/toxicants for humans ,using any of our adult human stem cells
4. To genetically-engineer our adult human stem cells for both basic mechanistic studies of stem cell differentiation or for gene therapy
5. To use our adult human stem cells for tissue regeneration/tissue replacement
6. To use our normal human adult stem cells for studying the mechanisms of human carcinogenesis in vitro( Test of stem cell theory of cancer)
7. To use the adult human stem cell markers for potential diagnostic screen of pre-malignant cancers

Industrial Relevance

1. Human screen for drugs and toxicants that might affect adult stem cells
2. Regeneration of human tissue using a non-ethically sensitive source of adult, not embryonic, stem cells
3. Pre-cancer diagnostic assay using our adult stem cell markers whichare found in cancer cells, as well as the pre-malignant lesions

Keywords

COS Keywords:

Cancer Or Carcinogenesis, Chemical Carcinogenesis, Diseases and Disorders, Environmental Toxicology, Genetic Toxicology, Genetics, Mutagenesis, Radiology, Risk Factor Analysis, Stem Cells, Toxicology.

Additional Terms:

Adult Human Stem Cells, Cancer Stem Cells, Chemical Induced Disease, Connexin Genes, Environmental Toxicology, Epigenetic Toxicology, Experimental Carcinogenesis, Gap Junctions, Genetic Toxicology, Human Diseases Theory, Human Mutagenesis, Human Radiation Mechanisms, Radiation Induced Disease, Risk Assessment Theory.

Languages

(Reading, Writing, Speaking)

German: (Basic, None, None)
Spanish: (Basic, None, None)
Japanese: (None, None, Basic)

Memberships

Academy of Toxicological Sciences
American Association for the Advancement of Science
Environmental Mutagenesis Society
Genetics Society of America
Sigma Xi, The Scientific Research Society
Society of Toxicology

Honors and Awards

2006-2006, "Brain Pool" award, Korean Ministry of Science and Technology, Seoul National University, Adult Stem Cell Reswearch
2002, Distinguished Alumni Award, Central Michigan University, Academic teaching and research
2001, Scientific Achievement Award, Society of Toxicology, Mechanisms of Epigenetic Toxicity
2001, Japan Society for the Promotion of Science, Dr. Tohru Inoue, JSPS-Tokyo, Excellence in Scientific Research and Education of Science for Japanese Students
1995, Kenneth DuBois Award, Midwest Region-Society of Toxicology, Epigenetic Toxicology
1987, Distinguished Faculty Award, Chairman of Pediatrics and Human Development, Michigan State University, Undergraduate, graduate, and medical Student teaching and research
1979, United kingdom's 'Searle' Award for pioneering research on DNA repair in mammalianSept., 1979 (University of Sussex, Environmental Mutagen Society, Sussex University, England), Pioneering research in mammalian DNA repair/mutagenesis
1972-1977, Natl. Cancer Institute's Career Development Award, Dr. William Weil, Michigan State University, Cancer Research on Tumor Promotion
1971, Outstanding Educator of America, OEA, Michigan State University, Undergraduate Teaching
1970, Teacher/Scholar Award, Dr. W. Weil, Chairperson, Pediatrics/Human debvelopment, Michigan State University, Undergraduate teaching and basic cancer research
Senior Scientist Award, Society of Sigma Xi-Scientific Honorary Society, Michigan State University, Basic cancer research

Previous Positions

1996-1997, President, MSU-Chapter Sigma Xi
1996-1997, Japan Agency for Science and Technology Award - Visiting Scientists, National Institute of Radiological Sciences- Chiba
1990-1992, Chief of Research, Radiation Effects Research Foundation
1972-1973, Visiting Professor, University of Wisconsin-Madison, McArdle Laboratory for Cancer Research

Patents

Oct-4 and GJIC expression as markers for adult human stem cells and metastic cells, Patent Number: Pending, 2004, Institution-Self Owned, United States.
Oct-4 and GJIC expression as markers for adult human stem cells and metastic cells, Patent Number: Pending, 2004, Institution-Self Owned, United States.
Oct-4 and GJIC expression as markers for adult human stem cells and metastic cells, Patent Number: Pending, 2004, Institution-Self Owned, United States.
Human Pancreatic Pluripotential Stem cell line, Patent Number: Pending, 2002, Michigan State University, United States.
Expression of estrogen receptors in Type I and Type II human breast epithelial cells, Patent Number: 6,140,119, 2000, Institution - self owned, United States.
Human Breast Epithelial Cell Type with Stem Cell and luminal epithelial cell characteristics, Patent Number: # 5650 317; # 5813511, 1997, Institution-Self-owned.

Funding Received

  • NIEHS: Environmental , Microbial and Mammalian Biomolecular Responses to AhR ligands, $838,552, 2006 to 2011.
  • National Institutes of Health (NIH): Epigenetic toxicity of polycyclic aromatic hydrocarbons, 2005 to 2007.
  • Pfizer Pharmaceuticals: Preliminary Exploration of the Role of Gap Junctions in Cardiac Pro-Arrhythmia, 2003 to 2003.
  • Barros Research Institute: Human Pancreatic Stem Cell Research, 2002 to 2003.
  • The McLaren Foundation: Isolation and Characterization of Normal Human Pancreatic Stem Cells, 2001 to 2002.
  • Electric Power Research Institute: Potential Role of Extremely Low Frequency Electric Magnetic Fields on Their Ability to Modulate Cell-Cell Communications, 1999 to 2000.
  • National Institute of Environmental Health Sciences: Environmental; Microbial; and Mammalian Biomolecular Responses to AHR Ligands, 1989 to 2007.

Publications

  • Umannová L, Neca J, Andrysík Z, Vondrácek J, Upham BL, Trosko JE, Hofmanová J, Kozubík A, Machala M (May 2008) Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: a partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1/2 signalling., Toxicology, 247 (1), 55-60 Abstract
  • Nakamura Y, Nakayama Y, Ando H, Tanaka A, Matsuo T, Okamoto S, Upham BL, Chang CC, Trosko JE, Park EY, Sato K (May 2008) 3-Methylthiopropionic acid ethyl ester, isolated from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon), enhanced differentiation in human colon cancer cells., Journal of agricultural and food chemistry, 56 (9), 2977-84 Abstract
  • Upham BL, Bláha L, Babica P, Park JS, Sovadinova I, Pudrith C, Rummel AM, Weis LM, Sai K, Tithof PK, Guzvić M, Vondrácek J, Machala M, Trosko JE (Apr 2008) Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C., Cancer science, 99 (4), 696-705 Abstract
  • Trosko JE (2008) Commentary: "re-programming or selecting adult stem cells?"., Stem cell reviews, 4 (2), 81-8 Abstract
  • Vondrácek J, Svihálková-Sindlerová L, Pencíková K, Marvanová S, Krcmár P, Ciganek M, Neca J, Trosko JE, Upham B, Kozubík A, Machala M (Nov 2007) Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines., Environmental toxicology and chemistry / SETAC, 26 (11), 2308-16 Abstract
  • Webster JD, Yuzbasiyan-Gurkan V, Trosko JE, Chang CC, Kiupel M (Nov 2007) Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasia., Veterinary pathology, 44 (6), 893-900 Abstract
  • Trosko JE (Aug 2007) Gap junctional intercellular communication as a biological "Rosetta stone" in understanding, in a systems biological manner, stem cell behavior, mechanisms of epigenetic toxicology, chemoprevention and chemotherapy., The Journal of membrane biology, 218 (1-3), 93-100 Abstract
  • Hirabayashi Y, Yoon BI, Tsuboi I, Huo Y, Kodama Y, Kanno J, Ott T, Trosko JE, Inoue T (Jun 2007) Membrane channel connexin 32 maintains Lin(-)/c-kit(+) hematopoietic progenitor cell compartment: analysis of the cell cycle., The Journal of membrane biology, 217 (1-3), 105-13 Abstract
  • Tai MH, Upham BL, Olson LK, Tsao MS, Reed DN, Trosko JE (May 2007) Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells., International journal of cancer. Journal international du cancer, 120 (9), 1855-62 Abstract
  • Hirabayashi Y, Yoon BI, Tsuboi I, Huo Y, Kodama Y, Kanno J, Ott T, Trosko JE, Inoue T (May 2007) Protective role of connexin 32 in steady-state hematopoiesis, regeneration state, and leukemogenesis., Experimental biology and medicine (Maywood, N.J.), 232 (5), 700-12 Abstract
  • Satoh AY, Trosko JE, Masten SJ (Apr 2007) Methylene blue dye test for rapid qualitative detection of hydroxyl radicals formed in a Fenton's reaction aqueous solution., Environmental science & technology, 41 (8), 2881-7 Abstract
  • Upham BL, Guzvić M, Scott J, Carbone JM, Blaha L, Coe C, Li LL, Rummel AM, Trosko JE (2007) Inhibition of gap junctional intercellular communication and activation of mitogen-activated protein kinase by tumor-promoting organic peroxides and protection by resveratrol., Nutrition and cancer, 57 (1), 38-47 Abstract
  • Trosko JE (Nov 2006) From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion., Annals of the New York Academy of Sciences, 1089, 36-58 Abstract
  • De Flora S, Scarfě S, Izzotti A, D'Agostini F, Chang CC, Bagnasco M, De Flora A, Trosko JE (Sep 2006) Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteine., International journal of oncology, 29 (3), 521-9 Abstract
  • Trosko JE, Tai MH (2006) Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells., Contributions to microbiology, 13, 45-65 Abstract
  • Trosko JE (2006) Dietary modulation of the multistage, multimechanisms of human carcinogenesis: effects on initiated stem cells and cell-cell communication., Nutrition and cancer, 54 (1), 102-10 Abstract
  • Nishikawa A, Sai K, Okazaki K, Son HY, Kanki K, Nakajima M, Kinae N, Nohmi T, Trosko JE, Inoue T, Hirose M (Jan 2006) MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells., Environmental and molecular mutagenesis, 47 (1), 48-55 Abstract
  • Trosko JE, Chang CC, Upham BL, Tai MH (Dec 2005) The role of human adult stem cells and cell-cell communication in cancer chemoprevention and chemotherapy strategies., Mutation research, 591 (1-2), 187-97 Abstract
  • Ogawa T, Hayashi T, Tokunou M, Nakachi K, Trosko JE, Chang CC, Yorioka N (Nov 2005) Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus., Cancer research, 65 (21), 9771-8 Abstract
  • Trosko JE (Oct 2005) The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy., Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie, 59 Suppl 2, S326-31 Abstract
  • Caruso RL, Upham BL, Harris C, Trosko JE (Aug 2005) Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells., Toxicological Sciences : an Official Journal of the Society of Toxicology, 86 (2), 417-26 Abstract
  • Loch-Caruso R, Upham BL, Harris C, Trosko JE (May 2005) Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions., Toxicological Sciences : an Official Journal of the Society of Toxicology, 85 (1), 694-702 Abstract
  • Trosko JE, Upham BL (Mar 2005) The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment., Mutagenesis, 20 (2), 81-92 Abstract
  • Luster-Teasley SL, Ganey PE, DiOrio M, Ward JS 3rd, Maleczka RE Jr, Trosko JE, Masten SJ (Mar 2005) Effect of byproducts from the ozonation of pyrene: biphenyl-2,2',6,6'-tetracarbaldehyde and biphenyl-2,2',6,6'-tetracarboxylic acid on gap junction intercellular communication and neutrophil function., Environmental Toxicology and Chemistry / Setac, 24 (3), 733-40 Abstract
  • Nakamura Y, Chang CC, Mori T, Sato K, Ohtsuki K, Upham BL, Trosko JE (Mar 2005) Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells., Carcinogenesis, 26 (3), 665-71 Abstract
  • Tai MH, Chang CC, Olson LK, Trosko JE (Feb 2005) Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis., Carcinogenesis, 26 (2), 495-502 Abstract
  • Trosko JE (2005) The role of stem cells and cell-cell communication in radiation carcinogenesis: ignored concepts., BJR supplement / BIR, 27, 132-8 Abstract
  • . Upham, B.L. and Trosko, J.E. (2005) A paradigm shift in the understanding of oxidative stress and its Implications to exposures of low level ionizing radiation, Acta Medica Nagasakiensia, 50, 63-68
  • Nakamura Y, Yoshikawa N, Hiroki I, Sato K, Ohtsuki K, Chang CC, Upham BL, Trosko JE (2005) Beta-sitosterol from psyllium seed husk (Plantago ovata Forsk) restores gap junctional intercellular communication in Ha-ras transfected rat liver cells., Nutrition and Cancer, 51 (2), 218-25 Abstract
  • Trosko JE, Chang CC, Upham BL, Tai MH (Dec 2004) Ignored hallmarks of carcinogenesis: stem cells and cell-cell communication., Annals of the New York Academy of Sciences, 1028, 192-201 Abstract
  • Trosko JE, Chang CC, Upham BL, Tai MH (Dec 2004) Ignored hallmarks of carcinogenesis: stem cells and cell-cell communication., Annals of the New York Academy of Sciences, 1028, 192-201 Abstract
  • Park JS, Noh DY, Kim SH, Kong G, Chang CC, Lee YS, Trosko JE, Kang KS (Jun 2004) Gene expression analysis in SV40-immortalized human breast luminal epithelial cells with stem cell characteristics using a cDNA microarray., International Journal of Oncology, 24 (6), 1545-58 Abstract
  • Moggs JG, Goodman JI, Trosko JE, Roberts RA (May 2004) Epigenetics and cancer: implications for drug discovery and safety assessment., Toxicology and Applied Pharmacology, 196 (3), 422-30 Abstract
  • Ogawa T, Hayashi T, Kyoizumi S, Kusunoki Y, Nakachi K, MacPhee DG, Trosko JE, Kataoka K, Yorioka N (Apr 2004) Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway., Journal of Cell Science, 117 (Pt 10), 2087-96 Abstract
  • Nakamura Y, Trosko JE, Chang CC, Upham BL (Jan 2004) Psyllium extracts decreased neoplastic phenotypes induced by the Ha-Ras oncogene transfected into a rat liver oval cell line., Cancer Letters, 203 (1), 13-24 Abstract
  • Hilscherova K, Blankenship A, Kannan K, Nie M, Williams LL, Coady K, Upham BL, Trosko JE, Bursian S, Giesy JP (Nov 2003) Oxidative stress in laboratory-incubated double-crested cormorant eggs collected from the Great Lakes., Archives of Environmental Contamination and Toxicology, 45 (4), 533-46 Abstract
  • Machala M, Blaha L, Vondracek J, Trosko JE, Scott J, Upham BL (Nov 2003) Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action., Toxicological Sciences : an Official Journal of the Society of Toxicology, 76 (1), 102-11 Abstract
  • Hilscherova K, Blankenship AL, Nie M, Coady KK, Upham BL, Trosko JE, Giesy JP (Sep 2003) Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD., Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp, 136 (1), 29-45 Abstract
  • Upham BL, Suzuki J, Chen G, Wang Y, McCabe LR, Chang CC, Krutovskikh VA, Yamasaki H, Trosko JE (Aug 2003) Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant-negative connexin 43., Molecular Carcinogenesis, 37 (4), 192-201 Abstract
  • Satoh AY, Trosko JE, Masten SJ (Jun 2003) Epigenetic toxicity of hydroxylated biphenyls and hydroxylated polychlorinated biphenyls on normal rat liver epithelial cells., Environmental Science & Technology, 37 (12), 2727-33 Abstract
  • Holland MS, Tai MH, Trosko JE, Griffin LD, Stasko JA, Cheville NC, Holland RE (Apr 2003) Isolation and differentiation of bovine mammary gland progenitor cell populations., American Journal of Veterinary Research, 64 (4), 396-403 Abstract
  • Upham BL, Rummel AM, Carbone JM, Trosko JE, Ouyang Y, Crawford RB, Kaminski NE (Mar 2003) Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line., International Journal of Cancer. Journal International Du Cancer, 104 (1), 12-8 Abstract
  • Na HK, Chang CC, Trosko JE (Mar 2003) Growth suppression of a tumorigenic rat liver cell line by the anticancer agent, ET-18-O-CH(3), is mediated by inhibition of cytokinesis., Cancer Chemotherapy and Pharmacology, 51 (3), 209-15 Abstract
  • Trosko JE (Mar 2003) Human stem cells as targets for the aging and diseases of aging processes., Medical Hypotheses, 60 (3), 439-47 Abstract
  • Upham BL, Koski TR, Rummel AM, Wilson MR, Horvath A, Trosko JE (Feb 2003) Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis., Cancer Letters, 191 (1), 27-34 Abstract
  • Tai MH, Olson LK, Madhukar BV, Linning KD, Van Camp L, Tsao MS, Trosko JE (Jan 2003) Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with stem cell characteristics., Pancreas, 26 (1), e18-26 Abstract
  • Trosko JE, Chang CC (2003) Isolation and characterization of normal adult human epithelial pluripotent stem cells., Oncology Research, 13 (6-10), 353-7 Abstract
  • Trosko JE (Jan 2003) The role of stem cells and gap junctional intercellular communication in carcinogenesis., Journal of Biochemistry and Molecular Biology, 36 (1), 43-8 Abstract
  • Trosko JE, Ruch RJ (Dec 2002) Gap junctions as targets for cancer chemoprevention and chemotherapy., Current Drug Targets, 3 (6), 465-82 Abstract
  • Hu W, Jones PD, Upham BL, Trosko JE, Lau C, Giesy JP (Aug 2002) Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo., Toxicological Sciences : an Official Journal of the Society of Toxicology, 68 (2), 429-36 Abstract
  • Horvath A, Upham BL, Ganev V, Trosko JE (Mar 2002) Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line., Toxicon : Official Journal of the International Society On Toxinology, 40 (3), 273-82 Abstract
  • Horvath A, Upham BL, Ganev V, Trosko JE (Mar 2002) Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line., Toxicon : Official Journal of the International Society On Toxinology, 40 (3), 273-82 Abstract
  • Luster-Teasley SL, Yao JJ, Herner HH, Trosko JE, Masten SJ (Mar 2002) Ozonation of chrysene: evaluation of byproduct mixtures and identification of toxic constituent., Environmental Science & Technology, 36 (5), 869-76 Abstract
  • Carruba G, Webber MM, Quader ST, Amoroso M, Cocciadiferro L, Saladino F, Trosko JE, Castagnetta LA (Feb 2002) Regulation of cell-to-cell communication in non-tumorigenic and malignant human prostate epithelial cells., The Prostate, 50 (2), 73-82 Abstract
  • Trosko JE, Chang CC (Sep 2001) Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer., Mutation Research, 480-481, 219-29 Abstract
  • Masten SJ, Tian M, Upham BL, Trosko JE (Jul 2001) Effect of selected pesticides and their ozonation by-products on gap junctional intercellular communication using rat liver epithelial cell lines., Chemosphere, 44 (3), 457-65 Abstract
  • Trosko JE (Mar 2001) Commentary: is the concept of "tumor promotion" a useful paradigm?, Molecular Carcinogenesis, 30 (3), 131-7 Abstract
  • Hayashi T, Trosko JE, Hamada K (Mar 2001) Inhibition of gap junctional intercellular communication in rat liver epithelial cells with transforming RNA., Febs Letters, 491 (3), 200-6 Abstract
  • Ruch RJ, Trosko JE, Gap-junction communication in chemical carcinogenesis., Drug Metabolism Reviews, 33(1), 117-24, Feb 2001 Abstract
  • Trosko JE, Chang CC (Jan 2001) Role of stem cells and gap junctional intercellular communication in human carcinogenesis., Radiation Research, 155 (1 Pt 2), 175-180 Abstract
  • Chang CC, Sun W, Cruz A, Saitoh M, Tai MH, Trosko JE (Jan 2001) A human breast epithelial cell type with stem cell characteristics as target cells for carcinogenesis., Radiation Research, 155 (1 Pt 2), 201-207 Abstract
  • Chen G, Upham BL, Sun W, Chang CC, Rothwell EJ, Chen KM, Yamasaki H, Trosko JE (Oct 2000) Effect of electromagnetic field exposure on chemically induced differentiation of friend erythroleukemia cells., Environmental Health Perspectives, 108 (10), 967-72 Abstract
  • Sai K, Kanno J, Hasegawa R, Trosko JE, Inoue T (Sep 2000) Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol., Carcinogenesis, 21 (9), 1671-6 Abstract
  • Na HK, Wilson MR, Kang KS, Chang CC, Grunberger D, Trosko JE (Aug 2000) Restoration of gap junctional intercellular communication by caffeic acid phenethyl ester (CAPE) in a ras-transformed rat liver epithelial cell line., Cancer Letters, 157 (1), 31-8 Abstract
  • DeoCampo ND, Wilson MR, Trosko JE (Aug 2000) Cooperation of bcl-2 and myc in the neoplastic transformation of normal rat liver epithelial cells is related to the down-regulation of gap junction-mediated intercellular communication., Carcinogenesis, 21 (8), 1501-6 Abstract
  • Trosko JE (Jul 2000) Human health consequences of environmentally-modulated gene expression: potential roles of ELF-EMF induced epigenetic versus mutagenic mechanisms of disease., Bioelectromagnetics, 21 (5), 402-6 Abstract
  • Trosko JE (Jun 2000) Cloning of human stem cells: some broad scientific and philosophical issues., The Journal of Laboratory and Clinical Medicine, 135 (6), 432-6 Abstract
  • Kang KS, Kang BC, Lee BJ, Che JH, Li GX, Trosko JE, Lee YS (Apr 2000) Preventive effect of epicatechin and ginsenoside Rb(2) on the inhibition of gap junctional intercellular communication by TPA and H(2)O(2)., Cancer Letters, 152 (1), 97-106 Abstract
  • Wilson MR, Close TW, Trosko JE, Cell population dynamics \(apoptosis, mitosis, and cell-cell communication\) during disruption of homeostasis., Experimental Cell Research, 254(2), 257-68, 1 2000 Abstract
  • Trosko JE, Chang CC, Wilson MR, Upham B, Hayashi T, Wade M (Feb 2000) Gap junctions and the regulation of cellular functions of stem cells during development and differentiation., Methods (san Diego, Calif.), 20 (2), 245-64 Abstract
  • Trosko JE, Chang CC (2000) Modulation of cell-cell communication in the cause and chemoprevention/chemotherapy of cancer., Biofactors (oxford, England), 12 (1-4), 259-63 Abstract
  • Suzuki J, Na HK, Upham BL, Chang CC, Trosko JE (2000) Lambda-carrageenan-induced inhibition of gap-junctional intercellular communication in rat liver epithelial cells., Nutrition and Cancer, 36 (1), 122-8 Abstract
  • Sun W, Kang KS, Morita I, Trosko JE, Chang CC, High susceptibility of a human breast epithelial cell type with stem cell characteristics to telomerase activation and immortalization., Cancer Research, 59(24), 6118-23, 15 Dec 1999 Abstract
  • Rummel AM, Trosko JE, Wilson MR, Upham BL, Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity., Toxicological Sciences, 49(2), 232-40, June 1999 Abstract
  • Kamendulis LM, Jiang J, Zhang H, deFeijter-Rupp H, Trosko JE, Klaunig JE, The effect of acrylonitrile on gap junctional intercellular communication in rat astrocytes., Cell Biology and Toxicology, 15(3), 173-83, 1999 Abstract
  • Trosko JE, Chang CC, Upham B, Wilson M, Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication., Toxicology Letters, 102-103, 71-8, 28 Dec 1998 Abstract
  • Sai K, Upham B L, Kang K S, Hasegawa R, Inoue T, Trosko J E, Inhibitory effect of pentachlorophenol on gap junctional intercellular communication in rat liver epithelial cells in vitro., Cancer Letters, 130(1-2), 9-17, 14 Aug 1998 Abstract
  • Upham B L, Weis L M, Trosko J E, Modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity: structure-function relationship., Environmental Health Perspectives, 106 Suppl 4, 975-81, August 1998 Abstract
  • Hayashi T, Nomata K, Chang C C, Ruch R J, Trosko J E, Cooperative effects of v-myc and c-Ha-ras oncogenes on gap junctional intercellular communication and tumorigenicity in rat liver epithelial cells., Cancer Letters, 128(2), 145-54, 19 Jun 1998 Abstract
  • Lawrence T S, Rehemtulla A, Ng E Y, Wilson M, Trosko J E, Stetson P L, Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine., Cancer Research, 58(12), 2588-93, 15 Jun 1998 Abstract
  • Rae R S, Mehta P P, Chang C C, Trosko J E, Ruch R J, Neoplastic phenotype of gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32., Molecular Carcinogenesis, 22(2), 120-7, June 1998 Abstract
  • de Feijter-Rupp H L, Hayashi T, Kalimi G H, Edwards P, Redpath J L, Chang C C, Stanbridge E J, Trosko J E, Restored gap junctional communication in non-tumorigenic HeLa-normal human fibroblast hybrids., Carcinogenesis, 19(5), 747-54, May 1998 Abstract
  • Kang K S, Sun W, Nomata K, Morita I, Cruz A, Liu C J, Trosko J E, Chang C C, Involvement of tyrosine phosphorylation of p185(c-erbB2/neu) in tumorigenicity induced by X-rays and the neu oncogene in human breast epithelial cells., Molecular Carcinogenesis, 21(4), 225-33, April 1998 Abstract
  • Trosko J E, Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents., Environmental Health Perspectives, 106 Suppl 1, 331-9, February 1998 Abstract
  • Trosko, J.E, R. Ruch, Cell to cell communication in carcinogenesis, Frontiers in Bioscience, 3, 208-236, 1998
  • Weis LM, Rummel AM, Masten SJ, Trosko JE, Upham BL, Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication., Environmental Health Perspectives, 106(1), 17-22, Jan 1998 Abstract
  • Wygoda M R, Wilson M R, Davis M A, Trosko J E, Rehemtulla A, Lawrence T S, Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: the Good Samaritan effect., Cancer Research, 57(9), 1699-703, 1 May 1997 Abstract
  • Trosko J E, Challenge to the simple paradigm that 'carcinogens' are 'mutagens' and to the in vitro and in vivo assays used to test the paradigm., Mutation Research, 373(2), 245-9, 3 Feb 1997 Abstract
  • Kang K S, Morita I, Cruz A, Jeon Y J, Trosko J E, Chang C C, Expression of estrogen receptors in a normal human breast epithelial cell type with luminal and stem cell characteristics and its neoplastically transformed cell lines., Carcinogenesis, 18(2), 251-7, February 1997 Abstract
  • Hayashi T, Matesic D F, Nomata K, Kang K S, Chang C C, Trosko J E, Stimulation of cell proliferation and inhibition of gap junctional intercellular communication by linoleic acid., Cancer Letters, 112(1), 103-11, 15 Jan 1997 Abstract
  • Trosko J E, Inoue T, Oxidative stress, signal transduction, and intercellular communication in radiation carcinogenesis., Stem Cells, 15 Suppl 2, 59-67, 1997 Abstract
  • Upham B L, Kang K S, Cho H Y, Trosko J E, Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells., Carcinogenesis, 18(1), 37-42, January 1997 Abstract
  • Upham B L, Weis L M, Rummel A M, Masten S J, Trosko J E, The effects of anthracene and methylated anthracenes on gap junctional intercellular communication in rat liver epithelial cells., Fundamental and Applied Toxicology, 34(2), 260-4, December 1996 Abstract
  • Matesic D F, Hayashi T, Trosko J E, Germak J A, Upregulation of gap junctional intercellular communication in immortalized gonadotropin-releasing hormone neurons by stimulation of the cyclic AMP pathway., Neuroendocrinology, 64(4), 286-97, October 1996 Abstract
  • Madhukar B V, de Feijter-Rupp H L, Trosko J E, Pulse treatment with the tumor promoter TPA delays the onset of desensitization response and prolongs the inhibitory effect on gap junctional intercellular communication of a rat liver epithelial cell, Cancer Letters, 106(1), 117-23, 23 Aug 1996 Abstract
  • de Feijter A W, Matesic D F, Ruch R J, Guan X, Chang C C, Trosko J E, Localization and function of the connexin 43 gap-junction protein in normal and various oncogene-expressing rat liver epithelial cells., Molecular Carcinogenesis, 16(4), 203-12, August 1996 Abstract
  • Hofer A, Saez J C, Chang C C, Trosko J E, Spray D C, Dermietzel R, C-erbB2/neu transfection induces gap junctional communication incompetence in glial cells., Journal of Neuroscience, 16(14), 4311-21, 15 Jul 1996 Abstract
  • Trosko J E, Role of low-level ionizing radiation in multi-step carcinogenic process., Health Physics, 70(6), 812-22, June 1996 Abstract
  • Nomata K, Kang K S, Hayashi T, Matesic D, Lockwood L, Chang C C, Trosko J E, Inhibition of gap junctional intercellular communication in heptachlor- and heptachlor epoxide-treated normal human breast epithelial cells., Cell Biology and Toxicology, 12(2), 69-78, April 1996 Abstract
  • Hashimoto M W, Nikaido O, Kobayashi N, Chang C C, Trosko J E, Mori T, A comparison of the propensity for gene amplification between near-tetraploid and near-diploid V79 clones resistant to 150 nM methotrexate., Carcinogenesis, 17(3), 389-94, March 1996 Abstract
  • Kang K S, Wilson M R, Hayashi T, Chang C C, Trosko J E, Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures., Environmental Health Perspectives, 104(2), 192-200, February 1996 Abstract
  • Lyng F M, de Feijter-Rupp H L, Hayashi T, O'Malley K, Murphy D M, Cottell D C, Trosko J E, Seymour C B, Mothersill C, Effect of a tobacco-related nitrosamine on intercellular communication in human urothelial cells: a possible factor in smoking-related bladder carcinogenesis., Oncology Research, 8(9), 371-8, 1996 Abstract
  • Trosko J E, Biomarkers for low-level exposure causing epigenetic responses in stem cells., Stem Cells, 13 Suppl 1, 231-9, May 1995 Abstract
  • Esinduy C B, Chang C C, Trosko J E, Ruch R J, In vitro growth inhibition of neoplastically transformed cells by non-transformed cells: requirement for gap junctional intercellular communication., Carcinogenesis, 16(4), 915-21, April 1995 Abstract
  • Jou Y S, Layhe B, Matesic D F, Chang C C, de Feijter A W, Lockwood L, Welsch C W, Klaunig J E, Trosko J E, Inhibition of gap junctional intercellular communication and malignant transformation of rat liver epithelial cells by neu oncogene., Carcinogenesis, 16(2), 311-7, February 1995 Abstract
  • Upham B L, Masten S J, Lockwood B R, Trosko J E, Nongenotoxic effects of polycyclic aromatic hydrocarbons and their oxygenation by-products on the intercellular communication of rat liver epithelial cells., Fundamental and Applied Toxicology, 23(3), 470-5, October 1994 Abstract
  • Trosko J E, Goodman J I, Intercellular communication may facilitate apoptosis: implications for tumor promotion., Molecular Carcinogenesis, 11(1), 8-12, September 1994 Abstract
  • Matesic D F, Rupp H L, Bonney W J, Ruch R J, Trosko J E, Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells., Molecular Carcinogenesis, 10(4), 226-36, August 1994 Abstract
  • Trosko J E, Chang C C, Madhukar B V, The role of modulated gap junctional intercellular communication in epigenetic toxicology., Risk Analysis, 14(3), 303-12, June 1994 Abstract
  • Ruch R J, Bonney W J, Sigler K, Guan X, Matesic D, Schafer L D, Dupont E, Trosko J E, Loss of gap junctions from DDT-treated rat liver epithelial cells., Carcinogenesis, 15(2), 301-6, February 1994 Abstract
  • Chaudhuri R, Sigler K, Dupont E, Trosko J E, Malkinson A M, Ruch R J, Gap junctional intercellular communication in mouse lung epithelial cell lines: effects of cell transformation and tumor promoters., Cancer Letters, 71(1-3), 11-8, 30 Jul 1993 Abstract
  • Oh S Y, Dupont E, Madhukar B V, Briand J P, Chang C C, Beyer E, Trosko J E, Characterization of gap junctional communication-deficient mutants of a rat liver epithelial cell line., European Journal of Cell Biology, 60(2), 250-5, April 1993 Abstract
  • Ruch R J, Madhukar B V, Trosko J E, Klaunig J E, Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorigenesis by lovastatin., Molecular Carcinogenesis, 7(1), 50-9, 1993 Abstract
  • Trosko J E, Madhukar B V, Chang C C, Endogenous and exogenous modulation of gap junctional intercellular communication: toxicological and pharmacological implications., Life Sciences, 53(1), 1-19, 1993 Abstract
  • Jou Y S, Matesic D, Dupont E, Lu S C, Rupp H L, Madhukar B V, Oh S Y, Trosko J E, Chang C C, Restoration of gap-junctional intercellular communication in a communication-deficient rat liver cell mutant by transfection with connexin 43 cDNA., Molecular Carcinogenesis, 8(4), 234-44, 1993 Abstract
  • de Feijter A W, Trosko J E, Krizman D B, Lebovitz R M, Lieberman M W, Correlation of increased levels of Ha-ras T24 protein with extent of loss of gap junction function in rat liver epithelial cells., Molecular Carcinogenesis, 5(3), 205-12, 1992 Abstract
  • Kalimi G H, Hampton L L, Trosko J E, Thorgeirsson S S, Huggett A C, Homologous and heterologous gap-junctional intercellular communication in v-raf-, v-myc-, and v-raf/v-myc-transduced rat liver epithelial cell lines., Molecular Carcinogenesis, 5(4), 301-10, 1992 Abstract
  • Hasler C M, Trosko J E, Bennink M R, Incorporation of n-3 fatty acids into WB-F344 cell phospholipids inhibits gap junctional intercellular communication., Lipids, 26(10), 788-92, October 1991 Abstract
  • Hasler C M, Bennink M R, Trosko J E, Inhibition of gap junction-mediated intercellular communication by alpha-linolenate., American Journal of Physiology, 261(1 Pt 1), C161-8, July 1991 Abstract
  • Kuslikis B I, Trosko J E, Braselton W E Jr, Mutagenicity and effect on gap-junctional intercellular communication of 4,4'-methylenebis(2-chloroaniline) and its oxidized metabolites., Mutagenesis, 6(1), 19-24, January 1991 Abstract
  • Loch-Caruso R, Corcos I A, Trosko J E, Inhibition of metabolic coupling by metals., Journal of Toxicology and Environmental Health, 32(1), 33-48, January 1991 Abstract
  • Trosko J E, Chang C C, Madhukar B V, Modulation of intercellular communication during radiation and chemical carcinogenesis., Radiation Research, 123(3), 241-51, September 1990 Abstract
  • Mori T, Matsunaga T, Chang C C, Trosko J E, Nikaido O, In situ (6-4)photoproduct determination by laser cytometry and autoradiography., Mutation Research, 236(1), 99-105, July 1990 Abstract
  • Hasler C M, Frick M A, Bennink M R, Trosko J E, TPA-induced inhibition of gap junctional intercellular communication is not mediated through free radicals., Toxicology and Applied Pharmacology, 103(3), 389-98, May 1990 Abstract
  • Ye Y X, Bombick D, Hirst K, Zhang G X, Chang C C, Trosko J E, Akera T, The modulation of gap junctional communication by gossypol in various mammalian cell lines in vitro., Fundamental and Applied Toxicology, 14(4), 817-32, May 1990 Abstract
  • Lin Z X, Chang C C, Trosko J E, Gap junctional intercellular communication (GJIC) in rat glioma cells--characterizations to detect inhibitors of metabolic cooperation., Science In china. Series B, Chemistry, Life Sciences and Earth Sciences, 33(4), 435-43, April 1990 Abstract
  • Li I C, Chang C C, Trosko J E, Thymidylate synthetase gene as a quantitative mutation marker in Chinese hamster cells., Mutation Research, 243(3), 233-9, March 1990 Abstract
  • De Feijter A W, Ray J S, Weghorst C M, Klaunig J E, Goodman J I, Chang C C, Ruch R J, Trosko J E, Infection of rat liver epithelial cells with v-Ha-ras: correlation between oncogene expression, gap junctional communication, and tumorigenicity., Molecular Carcinogenesis, 3(2), 54-67, 1990 Abstract
  • Trosko J E, Chang C C, Madhukar B V, Cell-to-cell communication: relationship of stem cells to the carcinogenic process., Progress In Clinical and Biological Research, 331, 259-76, 1990 Abstract
  • Trosko J E, Chang C C, Madhukar B V, Klaunig J E, Chemical, oncogene and growth factor inhibition gap junctional intercellular communication: an integrative hypothesis of carcinogenesis., Pathobiology, 58(5), 265-78, 1990 Abstract
  • Jankun J, Matsumura F, Kaneko H, Trosko J E, Pellicer A, Greenberg A H, Plasmid-aided insertion of MMTV-LTR and ras DNAs to NIH 3T3 fibroblast cells makes them responsive to 2,3,7,8-TCDD causing overexpression of p21ras and down-regulation of EGF receptor., Molecular Toxicology, 2(3), 177-86, July 1989 Abstract
  • Trosko, J.E., Chang, C.C., Madhukar, B.V., and Klaunig, J.E.: Chemical, oncogene and growth factor inhibition of gap junction intercellular communication: An integrative hypothesis of carcinogenesis. Pathobiol. 58:265-278, 1990
  • Chang, C.C., Trosko, J.E., El-Fouly, M., Gibson, R.E., and D'Ambrosio, S.: Contact insensitivity of a subpopulation of normal human fetal kidney epithelial cells and of human carcinoma cell lines. Cancer Res. 47:1634-1645, 1987
  • Wade, M.H., Trosko, J.E., and Schindler, M.: A fluorescence photobleaching assay of gap junction mediated cell-cell communication in human cells. Science 232:525-528, 1986
  • Chang, C.C., Trosko, J.E., Kung, H.J., Bombick, D., and Matsumura F: Potential role of src gene product in the inhibition of gap-junctional communication in NIH3T3 cells. Proc. Natl. Acad. Sci. 82:5360-5364, 1985
  • Yotti, L.P., Chang, C.C., and Trosko, J.E.: elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter. Science 206:1089-1091, 1979

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