Michael R. Van Scott

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East Carolina University
Brody School of Medicine
Physiology
ProfessorAppointed: 1990

Mailing Address

Brody 6N-98
East Carolina University
Greenville, North Carolina 27834-4354
United States

Contact Information

Phone: (252) 744-3654
Fax: (252) 744-3460
VANSCOTTMI@mail.ecu.edu

Qualifications

Post-doctoral fellow, Respiratory Division, 1986.
Ph.D., West Virginia University, Physiology, 1984.

Expertise and Research Interests

Mechanisms underlying obstructive airways diseases. Past projects include characterization of respiratory burst activity by alveolar macrophages in the context of black lung disease, definition of electrogenic ion transport processes across nonciliated bronchiolar epithelial cells as related to impaired mucociliary clearance in cystic fibrosis, and investigation of epithelial modulation of smooth muscle activity in allergic asthma. Current projects focus on the regulation and physiological manifestations of allergen- and particulate-induced airway inflammation. Collaborations with industry have supported the development of a non-human primate model of asthma for elucidation of the mechanisms underlying the chronic disease and evaluation of novel putative therapeutic approaches.

Other Expertise

Ion transport and epithelial biology; induction of allergic asthma in rodents, rabbits, and non-human primates; in vivo assessment of aerosolized therapeutics in laboratory animals.

Industrial Relevance

This laboratory collaborates extensively with industry in preclinical testing of emerging therapeutics for lung disease, particularly asthma.

Keywords

COS Keywords:

Animal Physiology or Morphology, Asthma, Human Physiology.

Additional Terms:

Airway Inflammation, Asthma, Particulate Matter.

Memberships

American Physiological Society

Previous Positions

1986-1990, Research Assistant Professor, University of North Carolina at Chapel Hill, School of Medicine, Medicine, Respiratory Diseases

Publications

  • Hazarika S, Van Scott MR, Lust RM, Myocardial Ischemia-reperfusion Injury Is Enhanced in a Model of Systemic Allergy and Asthma., American Journal of Physiology. Heart and Circulatory Physiology, 286(5), H1720-5, May 2004 Abstract
  • Van Scott MR, Hooker JL, Ehrmann D, Shibata Y, Kukoly C, Salleng K, Westergaard G, Sandrasagra A, Nyce J, Dust Mite-induced Asthma in Cynomolgus Monkeys., Journal of Applied Physiology (bethesda, Md. : 1985), 96(4), 1433-44, Apr 2004 Abstract
  • Fedan JS, Dowdy JA, Johnston RA, Van Scott MR, Hyperosmolar Solution Effects in Guinea Pig Airways. I. Mechanical Responses to Relative Changes in Osmolarity., The Journal of Pharmacology and Experimental Therapeutics, 308(1), 10-8, Jan 2004 Abstract
  • Fedan JS, Dowdy JA, Van Scott MR, Wu DX, Johnston RA, Hyperosmolar Solution Effects in Guinea Pig Airways. III. Studies on The Identity of Epithelium-derived Relaxing Factor in Isolated Perfused Trachea Using Pharmacological Agents., The Journal of Pharmacology and Experimental Therapeutics, 308(1), 30-6, Jan 2004 Abstract
  • Wu DX, Johnston RA, Rengasamy A, Van Scott MR, Fedan JS, Hyperosmolar Solution Effects in Guinea Pig Airways. II. Epithelial Bioelectric Responses to Relative Changes in Osmolarity., The Journal of Pharmacology and Experimental Therapeutics, 308(1), 19-29, Jan 2004 Abstract
  • Johnston RA, Van Scott MR, Kommineni C, Millecchia LL, Dortch-Carnes J, Fedan JS, Hyperosmolar Solution Effects in Guinea Pig Airways. IV. Lipopolysaccharide-induced Alterations in Airway Reactivity and Epithelial Bioelectric Responses to Methacholine and Hyperosmolarity., The Journal of Pharmacology and Experimental Therapeutics, 308(1), 37-46, Jan 2004 Abstract
  • Justice JP, Borchers MT, Lee JJ, Rowan WH, Shibata Y, Van Scott MR, Ragweed-induced Expression of GATA-3, IL-4, and IL-5 By Eosinophils in The Lungs of Allergic C57BL/6J Mice., American Journal of Physiology. Lung Cellular and Molecular Physiology, 282(2), L302-9, Feb 2002 Abstract
  • Shibata Y, Honda I, Justice JP, Van Scott MR, Nakamura RM, Myrvik QN, Th1 Adjuvant N-acetyl-D-glucosamine Polymer Up-regulates Th1 Immunity But Down-regulates Th2 Immunity Against a Mycobacterial Protein (MPB-59) In Interleukin-10-knockout and Wild-type Mice., Infection and Immunity, 69(10), 6123-30, Oct 2001 Abstract
  • Justice JP, Shibata Y, Sur S, Mustafa J, Fan M, Van Scott MR, IL-10 Gene Knockout Attenuates Allergen-induced Airway Hyperresponsiveness in C57BL/6 Mice., American Journal of Physiology. Lung Cellular and Molecular Physiology, 280(2), L363-8, Feb 2001 Abstract
  • Sur S, Bouchard P, Holbert D, Van Scott MR, Mucosal IL-12 Inhibits Airway Reactivity to Methacholine and Respiratory Failure in Murine Asthma., Experimental Lung Research, 26(6), 477-89, Sep 2000 Abstract
  • Sur S, Choudhury BK, Lam JS, Bouchard P, Wild JS, Sur N, Alam R, Sigounas A, Holbert D, Van Scott MR, Mucosal IL-12 Is More Effective Than Systemic IL-12 in Augmenting IFN-gamma Expression and Inhibiting Allergic Lung Eosinophilia in Murine Lungs., Experimental Lung Research, 26(6), 457-76, Sep 2000 Abstract
  • Van Scott MR, Justice JP, Bradfield JF, Enright E, Sigounas A, Sur S, IL-10 Reduces Th2 Cytokine Production and Eosinophilia But Augments Airway Reactivity in Allergic Mice., American Journal of Physiology. Lung Cellular and Molecular Physiology, 278(4), L667-74, Apr 2000 Abstract
  • Dortch-Carnes J, Van Scott MR, Fedan JS, Changes in smooth muscle tone during osmotic challenge in relation to epithelial bioelectric events in guinea pig isolated trachea, Journal of Pharmacology and Experimental Therapeutics, 289(2), 911-7, May 1999 Abstract
  • Shibata Y, Foster LA, Kurimoto M, Okamura H, Nakamura RM, Kawajiri K, Justice JP, Van Scott MR, Myrvik QN, Metzger WJ, Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-gamma-inducing factors but enhances NK cell production of IFN-gamma, Journal of Immunology, 161(8), 4283-8, October 1998 Abstract
  • Hay DW, Van Scott MR, Muccitelli RM, Characterization of endothelin release from guinea-pig tracheal epithelium: influence of proinflammatory mediators including major basic protein, Pulmonary Pharmacology and Therapeutics, 10(4), 189-98, August 1997 Abstract
  • Smith M D, Penland C M, Van Scott M R, Differential effects of polycationic protein on Cl- secretory and Na+ absorptive airways., American Journal of Physiology, 272(4 Pt 1), L762-71, April 1997 Abstract
  • Chinet T C, Gabriel S E, Penland C M, Sato M, Stutts M J, Boucher R C, Van Scott M R, CFTR-like chloride channels in non-ciliated bronchiolar epithelial (Clara) cells., Biochemical and Biophysical Research Communications, 230(2), 470-5, 13 Jan 1997 Abstract
  • Ghosh T K, Van Scott M R, Mathew O P, Activation of water-responsive laryngeal afferents: role of epithelial ion transport., Respiration Physiology, 105(3), 163-9, September 1996 Abstract
  • Van Scott M R, Smith M D, Welch C A, Bentzel C, Metzger W J, Bioelectric response of human nasal epithelial cells to polycationic protein., American Journal of Physiology, 271(1 Pt 1), L159-65, July 1996 Abstract
  • Van Scott M R, Penland C M, Welch C A, Lazarowski E, Beta-adrenergic regulation of Cl- and HCO3- secretion by Clara cells., American Journal of Respiratory Cell and Molecular Biology, 13(3), 344-51, September 1995 Abstract
  • Van Scott M R, Chinet T C, Burnette A D, Paradiso A M, Purinergic regulation of ion transport across nonciliated bronchiolar epithelial (Clara) cells., American Journal of Physiology, 269(1 Pt 1), L30-7, July 1995 Abstract
  • Ghosh T K, Van Scott M R, Mathew O P, Epithelial modulation of afferent nerve endings: differential effects of amiloride on afferent subtypes., Journal of Applied Physiology, 78(6), 2235-40, June 1995 Abstract
  • Lethem M I, Dowell M L, Van Scott M, Yankaskas J R, Egan T, Boucher R C, Davis C W, Nucleotide regulation of goblet cells in human airway epithelial explants: normal exocytosis in cystic fibrosis., American Journal of Respiratory Cell and Molecular Biology, 9(3), 315-22, September 1993 Abstract
  • Clarke L L, Burns K A, Bayle J Y, Boucher R C, Van Scott M R, Sodium- and chloride-conductive pathways in cultured mouse tracheal epithelium., American Journal of Physiology, 263(5 Pt 1), L519-25, November 1992 Abstract
  • Van Scott M R, Paradiso A M, Intracellular Ca2+ and regulation of ion transport across rabbit Clara cells., American Journal of Physiology, 263(1 Pt 1), L122-7, July 1992 Abstract
  • Davis C W, Dowell M L, Lethem M, Van Scott M, Goblet cell degranulation in isolated canine tracheal epithelium: response to exogenous ATP, ADP, and adenosine., American Journal of Physiology, 262(5 Pt 1), C1313-23, May 1992 Abstract
  • Retsch-Bogart G Z, Stiles A D, Moats-Staats B M, Van Scott M R, Boucher R C, D'Ercole A J, Canine tracheal epithelial cells express the type 1 insulin-like growth factor receptor and proliferate in response to insulin-like growth factor I., American Journal of Respiratory Cell and Molecular Biology, 3(3), 227-34, September 1990 Abstract

Profile Details

Last Updated: 8/8/2005

COS Expertise ID #370532
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