Victor E. Laubach

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University of Virginia
School of Medicine
Surgery
Thoracic & Cardiovascular Surgery
Associate ProfessorAppointed: 2003
University of Virginia
College and Graduate School of Arts and Sciences
Molecular Physiology & Biological Physics
Associate ProfessorAppointed: 2003
Professional Headshot of Victor E. Laubach

Mailing Address

Department of Surgery
P.O. Box 801359
Charlottesville, Virginia 22908
United States

Contact Information

Phone: (434) 924-2927
Fax: (434) 924-1218
laubach@virginia.edu

Qualifications

Ph.D., George Washington University, Genetics, 1993.
B.S., Pennsylvania State University, Biology, 1985.

Expertise and Research Interests

Pneumonectomy (removal of one lung) results in rapid compensatory growth of the remaining lung. The mechanisms that regulate this growth are unknown, and the long-term goal of my research is to understand the molecular mediators that trigger and regulate compensatory lung growth. Recently we have evaluated the impact of exogenous administration of retinoic acid, epidermal growth factor and keratinocyte growth factor on lung growth. We are currently studying the role of nitric oxide on compensatory lung growth. We have demonstrated that compensatory lung growth is impaired in eNOS- and iNOS-knockout mice, and we have shown that epidermal growth factor receptor and vascular endothelial growth factor (VEGF) are upregulated during compensatory lung growth. Our studies are directed at testing our overall hypothesis that nitric oxide is a key mediator of compensatory lung growth through the modulation of inflammation, angiogenesis and type II alveolar cell proliferation. Gene array studies are being conducted to help identify genes which play critical roles in compensatory lung growth. We are also conducting studies evaluating unequal growth among the lobes of the lung by measuring vascular growth, epithelial and endothelial proliferation and blood flow.

A second area of research in my lab is the study of lung ischemia-reperfusion (IR) injury. We have demonstrated that lung IR injury occurs as a biphasic response in which the acute phase is macrophage-dependent followed by a neutrophil-dependent phase of injury. This finding is important because it reinforces our concept that resident lung cells (i.e. cells residing in the donor lung rather than circulating leukocytes from the recipient) initiate IR injury upon transplantation. We have also demonstrated the rapid nuclear activation of NF-kappaB following lung transplantation and have shown that inhibition of NF-kappaB activation (during lung preservation) improves lung function and diminishes inflammation. We are now utilizing both a mouse in-situ, buffer-perfused, isolated lung model as well as an in vivo hilar clamp model of lung IR injury. Using various mouse knockout strains with these two models will we aim to determine how lung epithelial cells respond to IR, how they interact with alveolar macrophages, and how they participate in recruitment of neutrophils during IR injury.

In vitro studies are also being conducted using mouse macrophage cells (RAW) and type 2 alveolar epithelial cells (MLE-12) to evaluate the response of these cells to hypoxia-reoxygenation.

Expertise and other interests:
Molecular biology
Cellular biology
Nitric oxide
Heme oxygenase
Recombinant DNA
Cardiovascular biology
Inflammation
Growth factors and receptors
Gene regulation
Gene array
Animal models (pig, rabbit, rat, mouse)
Gene knockout
Angiogenesis

For further information, visit http://www.healthsystem.virginia.edu/internet/tcv-lab/PILaubach.cfm

Keywords

COS Keywords:

Angiogenesis, Animal Models, Cardiovascular Biology, Cell Biology, Gene Regulation, Gene Transfer, Growth Factor Receptors, Growth Factors, Inflammation, Injury Prevention, Ischemia, Organ Transplantation, Perfusion Or Reperfusion, Physiology, Preservation of Organs or Tissue, Pulmonary Diseases, Surgery, Thoracic Or Cardiovascular Surgery.

Additional Terms:

Alveolarization, Inflammation, Ischemia-Reperfusion Injury, Lung Biology, Lung Epithelial Cell, Lung Growth, Nitric Oxide, Nuclear Factor-kappa B, Pneumonectomy, Pulmonary.

Memberships

American Association for the Advancement of Science
American Heart Association
American Physiological Society
American Thoracic Society

Previous Positions

1996-2004, Assistant Professor of Research, University of Virginia, School of Medicine, Surgery, Thoracic & Cardiovascular Surgery
1993-1996, Postdoctoral Research Associate, Glaxo Wellcome, Inc., Cell and Molecular Biology, Research Triangle Park

Patents

Increased expression of alpha-1-antitrypsin in expression vectors through the inclusion of intron II, Patent Number: 5439824, 1995, Institution-owned, United States of America.

Funding Received

  • National Institutes of Health (NIH): Adenosine Receptor Activation and Lung Ischemia Reperfusion Injury, $1,000,000, 2008 to 2012.
  • National Institutes of Health (NIH): Resident Leukocytes in Lung Ischemia-Reperfusion Injury, $1,000,000, 2005 to 2009.
  • American Lung Association (ALA): Mechanisms of unequal lobar growth in post-pneumonectomy lung growth, $150,000, 2003 to 2006.
  • National Institutes of Health (NIH): Nitric oxide regulation of compensatory lung growth, $800,000, 2002 to 2007.
  • American Lung Association (ALA): Nitric Oxide Regulation of Compensatory Lung Growth, $50,000, 2001 to 2003.
  • American Heart Association (AHA): Mechanisms of Cellular Growth in Reduced-Size Lung Transplantation, $80,000, 1999 to 2001.

Publications

  • Laubach VE, Kron IL (Jul 2009) Pulmonary inflammation after lung transplantation., Surgery, 146 (1), 1-4 Abstract
  • Lau CL, Zhao Y, Kim J, Kron IL, Sharma A, Yang Z, Laubach VE, Linden J, Ailawadi G, Pinsky DJ (May 2009) Enhanced fibrinolysis protects against lung ischemia-reperfusion injury., The Journal of thoracic and cardiovascular surgery, 137 (5), 1241-8 Abstract
  • Yang Z, Sharma AK, Marshall M, Kron IL, Laubach VE (Mar 2009) NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury., American journal of respiratory cell and molecular biology, 40 (3), 375-81 Abstract
  • Yang Z, Laubach VE, French BA, Kron IL (Mar 2009) Acute hyperglycemia enhances oxidative stress and exacerbates myocardial infarction by activating nicotinamide adenine dinucleotide phosphate oxidase during reperfusion., The Journal of thoracic and cardiovascular surgery, 137 (3), 723-9 Abstract
  • Yang Z, Sharma AK, Linden J, Kron IL, Laubach VE (Mar 2009) CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury., The Journal of thoracic and cardiovascular surgery, 137 (3), 695-702; discussion Abstract
  • Sharma AK, Linden J, Kron IL, Laubach VE (2009) Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation., Respiratory research, 10, 58 Abstract
  • Lisle TC, Gazoni LM, Fernandez LG, Sharma AK, Bellizzi AM, Schifflett GD, Laubach VE, Kron IL (Nov 2008) Inflammatory lung injury after cardiopulmonary bypass is attenuated by adenosine A(2A) receptor activation., The Journal of Thoracic and Cardiovascular Surgery, 136 (5), 1280-7 Abstract
  • Ellman PI, Reece TB, Law MG, Gazoni LM, Singh R, Laubach VE, Linden J, Tribble CG, Kron IL (Sep 2008) Adenosine A2A activation attenuates nontransplantation lung reperfusion injury., The Journal of surgical research, 149 (1), 3-8 Abstract
  • Hussain SP, He P, Subleski J, Hofseth LJ, Trivers GE, Mechanic L, Hofseth AB, Bernard M, Schwank J, Nguyen G, Mathe E, Djurickovic D, Haines D, Weiss J, Back T, Gruys E, Laubach VE, Wiltrout RH, Harris CC (Sep 2008) Nitric oxide is a key component in inflammation-accelerated tumorigenesis., Cancer research, 68 (17), 7130-6 Abstract
  • Kondapaneni M, McGregor JR, Salvemini D, Laubach VE, Samlowski WE (May 2008) Inducible nitric oxide synthase (iNOS) is not required for IL-2-induced hypotension and vascular leak syndrome in mice., Journal of Immunotherapy, 31 (4), 325-33 Abstract
  • Sodini D, Baragatti B, Barogi S, Laubach VE, Coceani F (Apr 2008) Indomethacin promotes nitric oxide function in the ductus arteriosus in the mouse., British journal of pharmacology, 153 (8), 1631-40 Abstract
  • Gazoni LM, Laubach VE, Mulloy DP, Bellizzi A, Unger EB, Linden J, Ellman PI, Lisle TC, Kron IL (Jan 2008) Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusion., The Journal of thoracic and cardiovascular surgery, 135 (1), 156-65 Abstract
  • Gordon PV, Herman AC, Marcinkiewicz M, Gaston BM, Laubach VE, Aschner JL (Nov 2007) A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin., Journal of pediatric gastroenterology and nutrition, 45 (5), 509-19 Abstract
  • Fernandez LG, Mehta CK, Kron IL, Laubach VE (Nov 2007) Reinitiation of compensatory lung growth after subsequent lung resection., The Journal of thoracic and cardiovascular surgery, 134 (5), 1300-5 Abstract
  • Gilson WD, Epstein FH, Yang Z, Xu Y, Prasad KM, Toufektsian MC, Laubach VE, French BA (2007) Borderzone contractile dysfunction is transiently attenuated and left ventricular structural remodeling is markedly reduced following reperfused myocardial infarction in inducible nitric oxide synthase knockout mice., Journal of the American College of Cardiology, 50 (18), 1799-807 Abstract
  • Palmer LA, Doctor A, Chhabra P, Sheram ML, Laubach VE, Karlinsey MZ, Forbes MS, Macdonald T, Gaston B (Sep 2007) S-nitrosothiols signal hypoxia-mimetic vascular pathology., The Journal of clinical investigation, 117 (9), 2592-601 Abstract
  • Gazoni LM, Tribble CG, Zhao MQ, Unger EB, Farrar RA, Ellman PI, Fernandez LG, Laubach VE, Kron IL (Jul 2007) Pulmonary macrophage inhibition and inhaled nitric oxide attenuate lung ischemia-reperfusion injury., The Annals of thoracic surgery, 84 (1), 247-53 Abstract
  • Sharma AK, Fernandez LG, Awad AS, Kron IL, Laubach VE (Jul 2007) Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury., American journal of physiology. Lung cellular and molecular physiology, 293 (1), L105-13 Abstract
  • Baragatti B, Brizzi F, Barogi S, Laubach VE, Sodini D, Shesely EG, Regan RF, Coceani F (May 2007) Interactions between NO, CO and an endothelium-derived hyperpolarizing factor (EDHF) in maintaining patency of the ductus arteriosus in the mouse., British journal of pharmacology, 151 (1), 54-62 Abstract
  • Fernandez LG, Le Cras TD, Ruiz M, Glover DK, Kron IL, Laubach VE (Feb 2007) Differential vascular growth in postpneumonectomy compensatory lung growth., The Journal of thoracic and cardiovascular surgery, 133 (2), 309-16 Abstract
  • Singh RR, Laubach VE, Ellman PI, Reece TB, Unger E, Kron IL, Tribble CG (Dec 2006) Attenuation of lung reperfusion injury by modified ventilation and reperfusion techniques., The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 25 (12), 1467-73 Abstract
  • Zhao M, Fernandez LG, Doctor A, Sharma AK, Zarbock A, Tribble CG, Kron IL, Laubach VE (Nov 2006) Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury., American journal of physiology. Lung cellular and molecular physiology, 291 (5), L1018-26 Abstract
  • Miyoshi T, Li Y, Shih DM, Wang X, Laubach VE, Matsumoto AH, Helm GA, Lusis AJ, Shi W (Jul 2006) Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice., Life sciences, 79 (6), 525-31 Abstract
  • Maxey TS, Fernandez LG, Reece TB, Keeling WB, Kron IL, Laubach VE (Apr 2006) Endothelial nitric oxide synthase is essential for postpneumonectomy compensatory vasodilation., The Annals of thoracic surgery, 81 (4), 1234-8 Abstract
  • Park KS, Wells JM, Zorn AM, Wert SE, Laubach VE, Fernandez LG, Whitsett JA (Feb 2006) Transdifferentiation of ciliated cells during repair of the respiratory epithelium., American journal of respiratory cell and molecular biology, 34 (2), 151-7 Abstract
  • Palmer, LA, Laubach, VE, van Zudnert, AAJ (2005) An Interest in Research; An International Perspective, CPD Anaesthesia, 7 (2), 69-72
  • Reece TB, Laubach VE, Tribble CG, Maxey TS, Ellman PI, Warren PS, Schulman AM, Linden J, Kern JA, Kron IL (Apr 2005) Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury., The Annals of thoracic surgery, 79 (4), 1189-95 Abstract
  • Le Cras TD, Fernandez LG, Pastura PA, Laubach VE (Mar 2005) Vascular growth and remodeling in compensatory lung growth following right lobectomy., Journal of applied physiology (Bethesda, Md. : 1985), 98 (3), 1140-8 Abstract
  • Li D, Fernandez LG, Dodd-o J, Langer J, Wang D, Laubach VE (Mar 2005) Upregulation of hypoxia-induced mitogenic factor in compensatory lung growth after pneumonectomy., American journal of respiratory cell and molecular biology, 32 (3), 185-91 Abstract
  • Patel MR, Laubach VE, Tribble CG, Kron IL (Jan 2005) Hyperinflation during lung preservation and increased reperfusion injury., The Journal of surgical research, 123 (1), 134-8 Abstract
  • Hussain SP, Trivers GE, Hofseth LJ, He P, Shaikh I, Mechanic LE, Doja S, Jiang W, Subleski J, Shorts L, Haines D, Laubach VE, Wiltrout RH, Djurickovic D, Harris CC (Oct 2004) Nitric oxide, a mediator of inflammation, suppresses tumorigenesis., Cancer research, 64 (19), 6849-53 Abstract
  • Walsh KA, Megyesi JF, Wilson JX, Crukley J, Laubach VE, Hammond RR (May 2004) Antioxidant protection from HIV-1 gp120-induced neuroglial toxicity., Journal of neuroinflammation, 1 (1), 8 Abstract
  • Maxey TS, Enelow RI, Gaston B, Kron IL, Laubach VE, Doctor A (Feb 2004) Tumor necrosis factor-alpha from resident lung cells is a key initiating factor in pulmonary ischemia-reperfusion injury., The Journal of thoracic and cardiovascular surgery, 127 (2), 541-7 Abstract
  • Hsia CCW, Berberich MA, Driscoll B, Laubach VE, Lillehei CW, Massaro C, Perkett EA, Pierce RA, Rannels DE, Ryan RM, Tepper RS, Townsley MI, Veness-Meehan KA, Wang N, and Warburton D., American Thoracic Society Workshop Report: Mechanisms and Limits of Induced Postnatal Lung Growth, American Journal of Respiratory & Critical Care Medicine, 170, 319-343, 2004
  • Long SM, Laubach VE, Tribble CG, Kaza AK, Fiser SM, Cassada DC, Kern JA, Kron IL (Jun 2003) Pyrrolidine dithiocarbamate reduces lung reperfusion injury., The Journal of surgical research, 112 (1), 12-8 Abstract
  • Prorock AJ, Hafezi-Moghadam A, Laubach VE, Liao JK, Ley K (Jan 2003) Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase., American journal of physiology. Heart and circulatory physiology, 284 (1), H133-40 Abstract
  • Fiser SM, Tribble CG, Kaza AK, Long SM, Kern JA, Cassada DC, Linden J, Rieger J, Laubach VE, Matisoff A, Kron IL (Nov 2002) Adenosine A2A receptor activation decreases reperfusion injury associated with high-flow reperfusion., The Journal of thoracic and cardiovascular surgery, 124 (5), 973-8 Abstract
  • Kaza AK, Kron IL, Leuwerke SM, Tribble CG, Laubach VE (Sep 2002) Keratinocyte growth factor enhances post-pneumonectomy lung growth by alveolar proliferation., Circulation, 106 (12 Suppl 1), I120-4 Abstract
  • Fiser SM, Kron IL, Long SM, Kaza AK, Kern JA, Cassada DC, Laubach VE, Tribble CG (Jun 2002) Controlled perfusion decreases reperfusion injury after high-flow reperfusion., The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 21 (6), 687-91 Abstract
  • Leuwerke SM, Kaza AK, Tribble CG, Kron IL, Laubach VE (Jun 2002) Inhibition of compensatory lung growth in endothelial nitric oxide synthase-deficient mice., American journal of physiology. Lung cellular and molecular physiology, 282 (6), L1272-8 Abstract
  • Cassada DC, Tribble CG, Long SM, Laubach VE, Kaza AK, Linden J, Nguyen BN, Rieger JM, Fiser SM, Kron IL, Kern JA (May 2002) Adenosine A2A analogue ATL-146e reduces systemic tumor necrosing factor-alpha and spinal cord capillary platelet-endothelial cell adhesion molecule-1 expression after spinal cord ischemia., Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter, 35 (5), 994-8 Abstract
  • Hafezi-Moghadam A, Simoncini T, Yang Z, Limbourg FP, Plumier JC, Rebsamen MC, Hsieh CM, Chui DS, Thomas KL, Prorock AJ, Laubach VE, Moskowitz MA, French BA, Ley K, Liao JK (May 2002) Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase., Nature medicine, 8 (5), 473-9 Abstract
  • Barreiro E, Comtois AS, Gea J, Laubach VE, Hussain SN (Apr 2002) Protein tyrosine nitration in the ventilatory muscles: role of nitric oxide synthases., American journal of respiratory cell and molecular biology, 26 (4), 438-46 Abstract
  • Shi W, Wang X, Shih DM, Laubach VE, Navab M, Lusis AJ (Apr 2002) Paradoxical reduction of fatty streak formation in mice lacking endothelial nitric oxide synthase., Circulation, 105 (17), 2078-82 Abstract
  • Kaza AK, Cope JT, Fiser SM, Long SM, Kern JA, Tribble CG, Kron IL, Laubach VE (Feb 2002) Contrasting natures of lung growth after transplantation and lobectomy., The Journal of thoracic and cardiovascular surgery, 123 (2), 288-94 Abstract
  • Arnett HA, Hellendall RP, Matsushima GK, Suzuki K, Laubach VE, Sherman P, Ting JP (Jan 2002) The protective role of nitric oxide in a neurotoxicant-induced demyelinating model., Journal of immunology (Baltimore, Md. : 1950), 168 (1), 427-33 Abstract
  • Lee VG, Johnson ML, Baust J, Laubach VE, Watkins SC, Billiar TR (Nov 2001) The roles of iNOS in liver ischemia-reperfusion injury., Shock (Augusta, Ga.), 16 (5), 355-60 Abstract
  • Cassada DC, Tribble CG, Laubach VE, Nguyen BN, Rieger JM, Linden J, Kaza AK, Long SM, Kron IL, Kern JA (Sep 2001) An adenosine A2A agonist, ATL-146e, reduces paralysis and apoptosis during rabbit spinal cord reperfusion., Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter, 34 (3), 482-8 Abstract
  • Kaza AK, Kron IL, Long SM, Fiser SM, Stevens PM, Kern JA, Tribble CG, Laubach VE (Aug 2001) Epidermal growth factor receptor up-regulation is associated with lung growth after lobectomy., The Annals of thoracic surgery, 72 (2), 380-5 Abstract
  • Li D, Laubach VE, Johns RA (Aug 2001) Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS., American journal of physiology. Lung cellular and molecular physiology, 281 (2), L369-76 Abstract
  • Fiser SM, Tribble CG, Long SM, Kaza AK, Cope JT, Laubach VE, Kern JA, Kron IL (Jun 2001) Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response., The Journal of thoracic and cardiovascular surgery, 121 (6), 1069-75 Abstract
  • Kaza AK, Kron IL, Kern JA, Long SM, Fiser SM, Nguyen RP, Tribble CG, Laubach VE (May 2001) Retinoic acid enhances lung growth after pneumonectomy., The Annals of thoracic surgery, 71 (5), 1645-50 Abstract
  • Kaza AK, Laubach VE, Kern JA, Long SM, Fiser SM, Tepper JA, Nguyen RP, Shockey KS, Tribble CG, Kron IL (Nov 2000) Epidermal growth factor augments postpneumonectomy lung growth., The Journal of thoracic and cardiovascular surgery, 120 (5), 916-21 Abstract
  • Quinlan TR, Li D, Laubach VE, Shesely EG, Zhou N, Johns RA (Oct 2000) eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia., American journal of physiology. Lung cellular and molecular physiology, 279 (4), L641-50 Abstract
  • Boyle WA, Parvathaneni LS, Bourlier V, Sauter C, Laubach VE, Cobb JP (Sep 2000) iNOS gene expression modulates microvascular responsiveness in endotoxin-challenged mice., Circulation research, 87 (7), E18-24 Abstract
  • Hannan RL, John MC, Kouretas PC, Hack BD, Matherne GP, Laubach VE (Sep 2000) Deletion of endothelial nitric oxide synthase exacerbates myocardial stunning in an isolated mouse heart model., The Journal of surgical research, 93 (1), 127-32 Abstract
  • Ross SD, Kron IL, Gangemi JJ, Shockey KS, Stoler M, Kern JA, Tribble CG, Laubach VE (Sep 2000) Attenuation of lung reperfusion injury after transplantation using an inhibitor of nuclear factor-kappaB., American journal of physiology. Lung cellular and molecular physiology, 279 (3), L528-36 Abstract
  • Hampton TG, Amende I, Fong J, Laubach VE, Li J, Metais C, Simons M (Jul 2000) Basic FGF reduces stunning via a NOS2-dependent pathway in coronary-perfused mouse hearts., American journal of physiology. Heart and circulatory physiology, 279 (1), H260-8 Abstract
  • Cope JT, Gangemi JJ, Kaza AK, Ross SD, Long SM, Tepper JA, Nguyen RP, Shockey KS, Tribble CG, Kron EL, and Laubach VE, Cellular and molecular events mediating growth of mature pulmonary lobar transplants, Surgical Forum, LI, 137-138, 2000
  • Fiser SM, Tribble CG, Long SM, Kaza AK, Laubach VE, Cope JT, Kern JA, and Kron IL, The roles of pulmonary macrophages and circulating leukocytes in ischemia/reperfusion injury following lung transplantation, Surgical Forum, LI, 138-140, 2000
  • Mannon RB, Roberts K, Ruiz P, Laubach V, Coffman TM (Sep 1999) Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection., The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 18 (9), 819-27 Abstract
  • Guo Y, Jones WK, Xuan YT, Tang XL, Bao W, Wu WJ, Han H, Laubach VE, Ping P, Yang Z, Qiu Y, Bolli R (Sep 1999) The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene., Proceedings of the National Academy of Sciences of the United States of America, 96 (20), 11507-12 Abstract
  • Cobb JP, Hotchkiss RS, Swanson PE, Chang K, Qiu Y, Laubach VE, Karl IE, Buchman TG (Aug 1999) Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice., Surgery, 126 (2), 438-42 Abstract
  • Comtois AS, El-Dwairi Q, Laubach VE, Hussain SN (Jun 1999) Lipopolysaccharide-induced diaphragmatic contractile dysfunction in mice lacking the inducible nitric oxide synthase., American journal of respiratory and critical care medicine, 159 (6), 1975-80 Abstract
  • Laubach VE, Tribble CG, Ross SD, Shockey KS, Kron IL, Induction of heme oxygenase-1 in the lung after ischemia/reperfusion, Surgical Forum, L, 142-144, 1999
  • Laubach VE, Foley PL, Shockey KS, Tribble CG, Kron IL (Dec 1998) Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice., The American journal of physiology, 275 (6 Pt 2), H2211-8 Abstract
  • Kristof AS, Goldberg P, Laubach V, Hussain SN (Dec 1998) Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury., American journal of respiratory and critical care medicine, 158 (6), 1883-9 Abstract
  • King RC, Laubach VE, Kanithanon RC, Kron AM, Parrino PE, Shockey KS, Tribble CG, Kron IL (Nov 1998) Preservation with 8-bromo-cyclic GMP improves pulmonary function after prolonged ischemia., The Annals of thoracic surgery, 66 (5), 1732-8 Abstract
  • Parrino PE, Laubach VE, Gaughen JR, Shockey KS, Wattsman TA, King RC, Tribble CG, Kron IL (Sep 1998) Inhibition of inducible nitric oxide synthase after myocardial ischemia increases coronary flow., The Annals of thoracic surgery, 66 (3), 733-9 Abstract
  • Parrino PE, Kron IL, Ross SD, Shockey KS, Laubach VE, Kron IL, and Tribble CG, 8-Bromo cyclic guanosine monophosphate improves coronary flow during reperfusion without depression of left ventricular developed pressure, Surgical Forum, XLIX, 227-228, 1998
  • Cope JT, Banks D, Laubach VE, Binns OA, King RC, Richardson RM, Shockey KS, Tribble CG, Kron IL (Dec 1997) Sodium nitroprusside exacerbates myocardial ischemia-reperfusion injury., The Annals of thoracic surgery, 64 (6), 1656-9; discussion 1 Abstract
  • Binns OA, DeLima NF, Buchanan SA, Lopes MB, Cope JT, Marek CA, King RC, Laubach VE, Tribble CG, Kron IL (Aug 1997) Mature pulmonary lobar transplants grow in an immature environment., The Journal of thoracic and cardiovascular surgery, 114 (2), 186-94 Abstract
  • Laubach VE, Zhang CX, Russell SW, Murphy WJ, Sherman PA (Apr 1997) Analysis of expression and promoter function of the human inducible nitric oxide synthase gene in DLD-1 cells and monkey hepatocytes., Biochimica et biophysica acta, 1351 (3), 287-95 Abstract
  • Furfine ES, Carbine K, Bunker S, Tanoury G, Harmon M, Laubach V, Sherman P (1997) Potent inhibition of human neuronal nitric oxide synthase by N(G)-nitro-L-arginine methyl ester results from contaminating N(G)-nitro-L-arginine., Life sciences, 60 (20), 1803-9 Abstract
  • Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O (Nov 1996) Elevated blood pressures in mice lacking endothelial nitric oxide synthase., Proceedings of the National Academy of Sciences of the United States of America, 93 (23), 13176-81 Abstract
  • Zhang X, Laubach VE, Alley EW, Edwards KA, Sherman PA, Russell SW, Murphy WJ (Apr 1996) Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma., Journal of leukocyte biology, 59 (4), 575-85 Abstract
  • Laubach VE, Garvey EP, Sherman PA (Jan 1996) High-level expression of human inducible nitric oxide synthase in Chinese hamster ovary cells and characterization of the purified enzyme., Biochemical and biophysical research communications, 218 (3), 802-7 Abstract
  • Laubach VE, Shesely EG, Smithies O, Sherman PA (Nov 1995) Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death., Proceedings of the National Academy of Sciences of the United States of America, 92 (23), 10688-92 Abstract
  • Sherman PA, Laubach VE, Reep BR, Wood ER (Nov 1993) Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line., Biochemistry, 32 (43), 11600-5 Abstract
  • Laubach VE, Ryan WJ, Brantly M, Characterization of a human alpha 1-antitrypsin null allele involving aberrant mRNA splicing, Human Molecular Genetics, 2(7), 1001-5, 1993
  • Curiel D, Laubach V, Vogelmeier C, Wurts L, Crystal RG (Dec 1989) Characterization of the sequence of the normal alpha-1-antitrypsin M3 allele and function of the M3 protein., American journal of respiratory cell and molecular biology, 1 (6), 471-7 Abstract

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Profile Details

Last Updated: 9/2/2009

COS Expertise ID #831372
Reference this profile directly: http://myprofile.cos.com/vel8n