Dr. James G. Wagner

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Michigan State University
College of Veterinary Medicine
Pathobiology and Diagnostic Investigation

Mailing Address

Department of Pathobiology
Food Safety and Toxicology Bldg.
Michigan State University
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 432-1026
Fax: (517) 353-9902
wagnerja@msu.edu

Qualifications

Ph.D., Michigan State University, Pharmacology and Toxicology, 1998.
M.B.A., Michigan State University, Logistics Management, 1992.

Keywords

COS Keywords:

Pathobiology, Pharmacology, Respiratory System, Toxicology.

Additional Terms:

Respiratory Toxicology.

Memberships

American Thoracic Society
Society of Toxicology

Honors and Awards

2003, Paper of The Year Award, Society of Toxicology - Inhalation Specialty
2000-2001, National Service Rsearch Award, NIEHS
1991, Scientific Excellence Award, Michigan Society of Toxicology
1989, Scientific Excellence Award, Michigan Society of Toxicology

Funding Received

  • National Institutes of Health (NIH): Nasal Injury in Infant Monkeys Exposed to Ozone (Project 3 of Program Project), 191,800, 2006 to 2009.
  • Electrical Power Research Inst: Cardiopulmonary Toxicity Induced by Particulate Matter: Inhalation Toxicology Studies Using a Mobile Particle Concentrator, $524,327, 2005 to 2009.
  • NCCAM: Preclinical Evaluation of Cam Therapies for Asthma (Project 2), $288,800/yr, 2004 to 2009.
  • Health Effects Institute: Fine Airborne Particles and Allergic Airway Disease, $216,214/yr, 2003 to 2007.

Publications

  • Wagner JG, Jiang Q, Harkema JR, Ames BN, Illek B, Roubey RA, Peden DB (Mar 2008) Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 38 (3), 501-11 Abstract
  • Wagner JG, Jiang Q, Harkema JR, Illek B, Patel DD, Ames BN, Peden DB (Oct 2007) Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol., Free radical biology & medicine, 43 (8), 1176-88 Abstract
  • Wagner JG, Harkema JR (May 2007) Rodent models of allergic rhinitis: relevance to human pathophysiology., Current allergy and asthma reports, 7 (2), 134-40 Abstract
  • Carey SA, Minard KR, Trease LL, Wagner JG, Garcia GJ, Ballinger CA, Kimbell JS, Plopper CG, Corley RA, Postlethwait EM, Harkema JR, Einstein DR (2007) Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques., Toxicologic pathology, 35 (1), 27-40 Abstract
  • Keeler GJ, Morishita M, Wagner JG, Harkema JR (2007) Characterization of urban atmospheres during inhalation exposure studies in Detroit and Grand Rapids, Michigan., Toxicologic pathology, 35 (1), 15-22 Abstract
  • Sirivelu MP, MohanKumar SM, Wagner JG, Harkema JR, MohanKumar PS (2006) Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease., Environmental Health Perspectives, 114, 870-874
  • Morishita, M., Keeler, G.J., Wagner, J.G., JR Harkema (2006) Source identification of ambient PM2.5 during summer inhalation exposure studies in Detroit, MI, Atmospheric Environment, 40, 3835-3844
  • Harkema, JR, Carey, SA, Wagner, JG (2006) The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium, Toxicologic Pathology, 343 (30), 252-269
  • Harkema, Jack R., Wagner, James G., Epithelial and Inflammatory Responses in the Airways of Laboratory Rats Coexposed to Ozone and Biogenic Substances: Enhancement of Toxicant-induced Airway Injury, Experimental and Toxicologic Pathology, Elsevier, 57, 129-141, 2005
  • Morishita M, Keeler G, Wagner J, Marsik F, Timm E, Dvonch J, Harkema J, Pulmonary Retention of Particulate Matter Is Associated With Airway Inflammation in Allergic Rats Exposed to Air Pollution in Urban Detroit., Inhalation Toxicology, 16(10), 663-74, Sep 2004 Abstract
  • Harkema JR, Keeler G, Wagner J, Morishita M, Timm E, Hotchkiss J, Marsik F, Dvonch T, Kaminski N, Barr E, Effects of Concentrated Ambient Particles on Normal and Hypersecretory Airways in Rats., Research Report (health Effects Institute), 1-68; discussion 69-, Aug 2004 Abstract
  • Dvonch JT, Brook RD, Keeler GJ, Rajagopalan S, D'Alecy LG, Marsik FJ, Morishita M, Yip FY, Brook JR, Timm EJ, Wagner JG, Harkema JR, Effects of Concentrated Fine Ambient Particles on Rat Plasma Levels Of Asymmetric Dimethylarginine., Inhalation Toxicology, 16(6-7), 473-80, Jun 2004 Abstract
  • Wagner JG, Van Dyken SJ, Wierenga JR, Hotchkiss JA, Harkema JR, Ozone Exposure Enhances Endotoxin-induced Mucous Cell Metaplasia in Rat Pulmonary Airways., Toxicological Sciences : An Official Journal of the Society of Toxicology, 74(2), 437-46, Aug 2003 Abstract
  • Gavett SH, Haykal-Coates N, Highfill JW, Ledbetter AD, Chen LC, Cohen MD, Harkema JR, Wagner JG, Costa DL, World Trade Center Fine Particulate Matter Causes Respiratory Tract Hyperresponsiveness in Mice., Environmental Health Perspectives, 111(7), 981-91, Jun 2003 Abstract
  • Jefcoat AM, Wagner JG, Robinson NE, The Neutrophil: Understanding Ancient and Powerful Responses in The Inflammatory Balance., Equine Veterinary Journal, 35(1), 5-6, Jan 2003 Abstract
  • Wagner JG, Hotchkiss JA, Harkema JR, Enhancement of nasal inflammatory and epithelial responses after ozone and allergen coexposure in Brown Norway rats, Toxicological Sciences : an Official Journal of the Society of Toxicology., 67(2), 284-94, June 2002 Abstract
  • Wagner JG, Harkema JR, Roth RA, Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat, Shock (augusta, Ga.), 17(2), 151-8, February 2002 Abstract
  • Harkema JR, Wagner JG, Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways, Novartis Foundation Symposium, 248, 181-97; discussion 1, 2002 Abstract
  • Upham BL, Wagner JG, Toxicant-induced oxidative stress in cancer, Toxicological Sciences : an Official Journal of the Society of Toxicology., 64(1), 1-3, November 2001 Abstract
  • Wagner JG, Hotchkiss JA, Harkema JR, Effects of ozone and endotoxin coexposure on rat airway epithelium: potentiation of toxicant-induced alterations, Environmental Health Perspectives, 109 Suppl 4, 591-8, August 2001 Abstract
  • Wagner JG, Van Dyken SJ, Hotchkiss JA, Harkema JR, Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil-dependent in rat nasal epithelium, Toxicological Sciences : an Official Journal of the Society of Toxicology., 60(2), 338-47, April 2001 Abstract
  • Wagner JG, Deciphering the Inflammatory Signals in Bovine Respiratory Disease: Lessons From Human Studies., Veterinary Journal (london, England : 1997), 161(1), 8-9, Jan 2001 Abstract
  • Wagner JG, Roth RA, Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature, Pharmacological Reviews, 52(3), 349-74, September 2000 Abstract
  • Wagner JG, Roth RA, Neutrophil migration during endotoxemia, Journal of Leukocyte Biology, 66(1), 10-24, July 1999 Abstract
  • Wagner JG, Driscoll KE, Roth RA, Inhibition of pulmonary neutrophil trafficking during endotoxemia is dependent on the stimulus for migration, American Journal of Respiratory Cell and Molecular Biology, 20(4), 769-76, April 1999 Abstract
  • Wagner JG, Ganey PE, Roth RA, Nitric oxide is not involved in hepatocyte killing by neutrophils activated by N-formyl-methionyl-leucylphenylalanine or phorbol myristate acetate in vitro, Hepatology (baltimore, Md.), 23(4), 803-10, April 1996 Abstract
  • Hoorn CM, Wagner JG, Petry TW, Roth RA, Toxicity of mitomycin C toward cultured pulmonary artery endothelium, Toxicology and Applied Pharmacology, 130(1), 87-94, January 1995 Abstract

Profile Details

Last Verified: 9/9/2008

COS Expertise ID #1100900
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