James S. Wefel

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University of Iowa
College of Dentistry
Pediatric Dentistry
ProfessorAppointed: 1972
University of Iowa
College of Dentistry
Dows Institute for Dental Research
DirectorAppointed: 1972
Professional Headshot of James S. Wefel

Mailing Address

N413 DSB
University of Iowa
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 335-7376
Fax: (319) 335-8895
wefel-james@uiowa.edu

Qualifications

Ph.D., State University of New York at Buffalo, 1972.
B.S., Valapraiso University, 1968.

Expertise and Research Interests

Areas of research include laser and tooth interactions, early caries detection, mechanisms of action of fluoride, topical fluorides, remineralization, kinetics of calcium phosphate crystal growth, secondary caries, oral fluoride kinetics, antimicrobials, and F-releasing materials. Specific research in the Dows Institute for Dental Research includes root surface caries, laser prevention of tooth demineralization, and F-releasing biomaterials and secondary caries. Activities include promotion of research from the laboratory to the clinical in the Center for Clinical Studies.

Other Expertise

Administrative Director of the Office of Clinical Research.

Keywords

COS Keywords:

Caries, Dental Health and Hygiene, Dental Health Education, Dentistry, Disease Model, Preventive Dentistry, Volunteers.

Additional Terms:

Caries, Chemotherapeutic Agent, Dental Health, Dental Health Education, Dental Hygiene, Dentistry, Disease Model, Oral Disease, Periodontal Disease, Preventive Dentistry, Volunteers.

Memberships

American Association for Dental Research
American Dental Education Association (ADEA)
European Association of Caries Research
International Association for Dental Research
New York Academy of Sciences

Previous Positions

Center for Clinical Studies, Director
Head of the Division of Cariology, Dental School
Specialized Caries Research Center, Director

Funding Received

  • National Institutes of Health (NIH): Principal Investigator, Specialized Caries Research Center, $2,725,689, Sep 30, 1994 to Sep 29, 2000.
  • National Institutes of Health (NIH): Principal Investigator, Oral Health Research Clinical Core Center, $4,571,326, Sep 15, 1991 to Jul 31, 2002.
  • National Institutes of Health (NIH): Co-Investigator, Longitudinal Study of Fluoride Exposures and Dental Fluoride, Steven Levy, PI, $4,783,747, Sep 1, 1991 to Mar 31, 2005.
  • United States Department of Agriculture (USDA): Co-Investigator, Fluoride Analysis to Support NDS-R Component & USDA National Fluoride Database, Steven Levy, PI, $250,000, Nov 1, 2001 to Oct 31, 2004.
  • Procter & Gamble Company: Principal Investigator, Evaluation of Dentifrice Components In Situ, $134,500, May 7, 2001 to Jun 30, 2002.
  • Procter & Gamble Company: Principal Investigator, Evaluation of Dentifrice Components In Situ, $119,500, May 15, 1999 to May 15, 2000.
  • Procter & Gamble Company: Principal Investigator, In Vitro Evaluation of Fluoride Products, May 11, 2000 to Dec 31, 2001.
  • Procter & Gamble Company: Principal Investigator, Multi-Site in Vitro Validation Study for Quantitative Light Fluorescence (QLF), $7,000, Mar 30, 1998 to Dec 31, 1998.
  • National Institutes of Health (NIH): Principal Investigator, Early Caries Detection and Intervention, $5,700,313, Mar 1, 2001 to Dec 31, 2005.
  • Procter & Gamble Company: Principal Investigator, Intraoral Dentifrice Evaluation, $80,000, Jun 1, 1997 to Jun 30, 1999.
  • University of Illinois: Principal Investigator, The Effects of Black Tea Infusion on Demineralization/Remineralization, $16,000, Jul 1, 1998 to Dec 31, 1999.

Publications

  • Schmit JL, Staley RN, Wefel JS, Kanellis M, Jakobsen JR, Keenan PJ, Effect of fluoride varnish on demineralization adjacent to brackets bonded with RMGI cement, American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics., 122(2), 125-34, Aug 2002 Abstract
  • Wefel JS, Stanford CM, Ament DK, Hogan MM, Harless JD, Pfarrer AM, Ramsey LL, Leusch MS, Biesbrock AR, In situ evaluation of sodium hexametaphosphate-containing dentifrices, Caries Research, 36(2), 122-8, 2002 Abstract
  • Levy SM, Warren JJ, Davis CS, Kirchner HL, Kanellis MJ, Wefel JS, Patterns of fluoride intake from birth to 36 months, Journal of Public Health Dentistry, 61(2), 70-7, Spring 2001 Abstract
  • Levy SM, McGrady JA, Bhuridej P, Warren JJ, Heilman JR, Wefel JS, Factors affecting dentifrice use and ingestion among a sample of U.S. preschoolers, Pediatric Dentistry, 22(5), 389-94, 2000 Abstract
  • Heilman JR, Kiritsy MC, Levy SM, Wefel JS, Assessing fluoride levels of carbonated soft drinks, Journal of the American Dental Association, 130(11), 1593-9, November 1999 Abstract
  • Todd MA, Staley RN, Kanellis MJ, Donly KJ, Wefel JS, Effect of a fluoride varnish on demineralization adjacent to orthodontic brackets, American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics, 116(2), 159-67, August 1999 Abstract
  • Vorhies AB, Donly KJ, Staley RN, Wefel JS, Enamel demineralization adjacent to orthodontic brackets bonded with hybrid glass ionomer cements: an in vitro study., American Journal of Orthodontics and Dentofacial Orthopedics, 114(6), 668-74, December 1998 Abstract
  • Hsu C Y, Donly K J, Drake D R, Wefel J S, Effects of aged fluoride-containing restorative materials on recurrent root caries., Journal of Dental Research, 77(2), 418-25, February 1998 Abstract
  • Segura A, Donly K J, Wefel J S, Drake D, Effect of enamel microabrasion on bacterial colonization., American Journal of Dentistry, 10(6), 272-4, December 1997 Abstract
  • Narhi T O, Ettinger R L, Heilman J R, Wefel J S, Salivary fluoride levels in overdenture wearers after topical fluoride gel application., International Journal of Prosthodontics, 10(6), 553-61, November 1997 Abstract
  • Ettinger R L, Olson R J, Wefel J S, Asmussen C, In vitro evaluation of topical fluorides for overdenture abutments., Journal of Prosthetic Dentistry, 78(3), 309-14, September 1997 Abstract
  • Heilman J R, Kiritsy M C, Levy S M, Wefel J S, Fluoride concentrations of infant foods., Journal of The American Dental Association, 128(7), 857-63, July 1997 Abstract
  • Segura A, Donly K J, Wefel J S, The effects of microabrasion on demineralization inhibition of enamel surfaces., Quintessence International, 28(7), 463-6, July 1997 Abstract
  • Heilman J R, Jordan T H, Warwick R, Wefel J S, Remineralization of root surfaces demineralized in solutions of differing fluoride levels., Caries Research, 31(6), 423-8, 1997 Abstract
  • Marinelli C B, Donly K J, Wefel J S, Jakobsen J R, Denehy G E, An in vitro comparison of three fluoride regimens on enamel remineralization., Caries Research, 31(6), 418-22, 1997 Abstract
  • ten Cate J M, Dundon K A, Vernon P G, Damato F A, Huntington E, Exterkate R A, Wefel J S, Jordan T, Stephen K W, Roberts A J, Preparation and measurement of artificial enamel lesions, a four-laboratory ring test., Caries Research, 30(6), 400-7, 1996 Abstract
  • Levy S M, Kohout F J, Kiritsy M C, Heilman J R, Wefel J S, Infants' fluoride ingestion from water, supplements and dentifrice., Journal of The American Dental Association, 126(12), 1625-32, December 1995 Abstract
  • Wefel J S, Working Group Report 2: In situ caries models, saliva, microbiology, and statistical considerations., Advances In Dental Research, 9(3), 335-7, November 1995 Abstract
  • Wefel J S, Jensen M E, Triolo P T, Faller R V, Hogan M M, Bowman W D, De/remineralization from sodium fluoride dentifrices., American Journal of Dentistry, 8(4), 217-20, August 1995 Abstract
  • Van Winkle S, Levy S M, Kiritsy M C, Heilman J R, Wefel J S, Marshall T, Water and formula fluoride concentrations: significance for infants fed formula., Pediatric Dentistry, 17(4), 305-10, July 1995 Abstract
  • Levy S M, Kohout F J, Guha-Chowdhury N, Kiritsy M C, Heilman J R, Wefel J S, Infants' fluoride intake from drinking water alone, and from water added to formula, beverages, and food., Journal of Dental Research, 74(7), 1399-407, July 1995 Abstract
  • Wefel J S, In situ caries model: reactor paper, Advances in Dental Research, 9(3), 231-234, 1995
  • Wefel J S, Heilman J R, Jordan T H, Comparisons of in vitro root caries models, Caries Research, 29(3), 204-9, 1995 Abstract
  • Wefel J S, Root caries histopathology and chemistry., American Journal of Dentistry, 7(5), 261-5, October 1994 Abstract
  • Swift E J, Hammel S A, Perdigao J, Wefel J S, Prevention of root surface caries using a dental adhesive., Journal of The American Dental Association, 125(5), 571-6, May 1994 Abstract
  • Perdigao J, Swift E J Jr, Denehy G E, Wefel J S, Donly K J, In vitro bond strengths and SEM evaluation of dentin bonding systems to different dentin substrates., Journal of Dental Research, 73(1), 44-55, January 1994 Abstract
  • Drake D R, Wefel J S, Dunkerson D, Hogle K, The antimicrobial activity of Prevention mouthrinse., American Journal of Dentistry, 6(5), 239-42, October 1993 Abstract
  • Stookey G K, DePaola P F, Featherstone J D, Fejerskov O, Moller I J, Rotberg S, Stephen K W, Wefel J S, A critical review of the relative anticaries efficacy of sodium fluoride and sodium monofluorophosphate dentifrices., Caries Research, 27(4), 337-60, 1993 Abstract
  • Ettinger R L, Ahmad R, Wefel J S, Effect of fluoride concentrations on overdenture abutments., American Journal of Dentistry, 5(4), 199-202, August 1992 Abstract
  • Wefel J S, Jensen M E, An intra-oral single-section demineralization/remineralization model., Journal of Dental Research, 71 Spec No, 860-3, April 1992 Abstract
  • Wefel J S, Consensus conference on intra-oral models: patient selection, appliance design, and substrate., Journal of Dental Research, 71 Spec No, 954, April 1992 Abstract
  • Triolo P T, Wefel J S, Jensen M E, Fluoride-releasing core build-up materials and artificial caries., American Journal of Dentistry, 4(5), 207-10, October 1991 Abstract
  • Swift E J Jr, Linden J J, Wefel J S, Effects of the XR-bonding system on in vitro caries., American Journal of Dentistry, 4(4), 157-61, August 1991 Abstract
  • Jensen M E, Wefel J S, Hammesfahr P D, Fluoride-releasing liners: in vitro recurrent caries., General Dentistry, 39(1), 12-7, January 1991 Abstract
  • Jensen M E, Garcia-Godoy F, Wefel J S, Artificial root caries in amalgam restorations: effect of light-cured fluoride releasing liners., American Journal of Dentistry, 3(6), 295-8, December 1990 Abstract
  • Jensen M E, Wefel J S, Effects of processed cheese on human plaque pH and demineralization and remineralization., American Journal of Dentistry, 3(5), 217-23, October 1990 Abstract
  • Jensen M E, Wefel J S, Triolo P T, Hammesfahr P D, Effects of a fluoride-releasing fissure sealant on artificial enamel caries., American Journal of Dentistry, 3(2), 75-8, April 1990 Abstract
  • Wefel J S, Effects of fluoride on caries development and progression using intra-oral models., Journal of Dental Research, 69 Spec No, 626-33; discussion 6, February 1990 Abstract
  • Itthagaran A, Wei S H Y, Wefel J S, De/remineralization from different commercial dentifrices: a pH-cycling study, Int Dent J, 47, 320-328, 1987
  • Wefel, J.S., Jensen, M.E., Triolo, P.T., Faller, R.V., Hogan, M.M. and Bowman, W.D. De/mineralization from sodium fluoride dentifrices. Am J Dent 8:217-220, 1995
  • Van Winkle, S., Levy, S.M., Kiritsy, M.C., Heilman, J.R., Wefel, J.S. and Marshall, T. Water and formula concentrations: significance for infants fed formula. Ped Dent 17(4):305-310, 1995
  • Wefel, J.S., Heilman, J.R. and Jordan, T.H. Comparisons of in vitro root caries models. Caries Res 29(3):163-242, 1995
  • Levy, S.M., Kohout, F.J., Guha-Chowdhury, N., Kiritsy, M.C., Heilman, J.R. and Wefel, J.S. Fluoride intake from water itself and water added to formula, beverages and food - a longitudinal study. J Dent Res 1994 (Accepted)
  • Wefel, J.S. Root caries histopathology and chemistry. Am J Dent 7:261-265, 1994

Profile Details

Last Updated: 2/4/2003

COS Expertise ID #216886
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