Mark H. Wener

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University of Washington
School of Medicine
Adjunct; Department of Medicine
Immunology Division
Professor, DirectorAppointed: 2005
University of Washington
Clinical Nutrition Research Unit Laboratory Core
Appointed: 1998
Professional Headshot of Mark H. Wener

Mailing Address

Department of Laboratory Medicine
University of Washington Medical Center
Box 357110
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 598-6131
Fax: (206) 598-6189
wener@u.washington.edu

Qualifications

Certified, American Board of Allergy and Immunology, Clinical Laboratory Immunology, 1986.
Medical License #18289, State of Washington, 1980.
Certified, American Board of Internal Medicine (ABIM), Internal Medicine, 1980.
Certified, American Board of Internal Medicine, Rheumatology, 1980.
Certified, National Board of Medical Examiners, 1975.
M.D., University of Washington, Medicine, 1974.

Expertise and Research Interests

Performance characteristics of immunoassays
Mechanism of immune complex deposition in lupus nephritis
Autoantibodies to C1q complement component
Autoimmune rheumatic diseases
Immune complex assays
Cryoglobulinemia and hepatitis C-related rheumatic diseases
Performance of tumor marker assays
Laboratory markers of nutritional status
Central nervous system lupus
Stem cell transplant for autoimmune rheumatic disease
Computer-based laboratory tutors
Effect of exercise on immune function

Keywords

COS Keywords:

Autoimmunity, Bioassay, Biotechnology, Central Nervous System, Computer-Aided Instruction, Immune System, Kidney Disease, Lupus, Nephrology, Rheumatic Diseases, Rheumatology.

Additional Terms:

Biotechnology, Immunology, Lab Medicine, Nephrology, Renal Disease, Rheumatology, Vasculitis.

Memberships

Academy of Clinical Laboratory Physicians and Scientists
Academy of Clinical Laboratory Physicians and Scientists Clinical Pathology Curriculum Development Committee. Chair, Immunology Curriculum Development Subcommittee
American Association for Clinical Chemistry
American College of Physicians
American College of Rheumatology
Association for Clinical Laboratory Immunology
Autoimmune Bone Marrow & Stem Cell Transplant Protocol Development Committee, Fred Hutchinson Cancer Center
Clerkship Curriculum Committee, School of Medicine, University of Washington
Clinical Nutrition Research Unit Grant Review Committee, University of Washington
Laboratory Continuing Quality Improvement (CQI) Committee, University of Washington
Leadership Comittee, Department of Laboratory Medicine, University of Washington
Search Committee, Pediatric Rheumatology Faculty, University of Washington
Standing Comittee on Issues of Women Faculty, School of Medicine, University of Washington
Unversity of Washington Lupus Clinic

Honors and Awards

2001-2006, "America's Top Doctors", Castle Connolly Medical Ltd
2000-2002, 'Best Doctors',

Previous Positions

1999-2005, Associate Professor, Director, University of Washington, Adjunct; Department of Medicine, Department of Laboratory Medicine, Immunology Division
1997-2005, Director, Endocrinology Section, University of Washington, School of Medicine, Department of Laboratory Medicine, Chemistry Division
1990-1998, Associate Professor, University of Washington, School of Medicine, Laboratory Medicine
1990-1998, Associate Professor, University of Washington, School of Medicine, Medicine, Rheumatology

Publications

  • Drain PK, Baeten JM, Overbaugh J, Wener MH (2006) Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women, BMC Infectious Disease, 19 (6), 85
  • Potter AJ, Wener (2005) Flow cytometric analysis of fluorescence in situ hybridization with dye dilution and DNA staining (flow-FISH-DDD) to determine telomere length dynamics in proliferating cells., Cytometry A (68), 53-8
  • Wener MH, Hutchinson K, Morishima C, Gretch DR (Jul 2004) Absence of antibodies to cyclic citrullinated peptide in sera of patients with hepatitis C virus infection and cryoglobulinemia., Arthritis and Rheumatism, 50 (7), 2305-8 Abstract
  • Peterson JR, Hsu FC, Simkin PA, Wener MH (Nov 2003) Effect of tumour necrosis factor alpha antagonists on serum transaminases and viraemia in patients with rheumatoid arthritis and chronic hepatitis C infection., Annals of the Rheumatic Diseases, 62 (11), 1078-82 Abstract
  • Mannik M, Merrill CE, Stamps LD, Wener MH (Jul 2003) Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus., The Journal of Rheumatology, 30 (7), 1495-504 Abstract
  • Jefferson JA, Escudero E, Hurtado ME, Kelly JP, Swenson ER, Wener MH, Burnier M, Maillard M, Schreiner GF, Schoene RB, Hurtado A, Johnson RJ, Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemia, American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation., 39(6), 1135-42, June 2002 Abstract
  • Kohro-Kawata J, Wener MH, Mannik M, The effect of high salt concentration on detection of serum immune complexes and autoantibodies to C1q in patients with systemic lupus erythematosus, Journal of Rheumatology, 29(1), 84-9, January 2002 Abstract
  • Taneda S, Segerer S, Hudkins KL, Cui Y, Wen M, Segerer M, Wener MH, Khairallah CG, Farr AG, Alpers CE, Cryoglobulinemic glomerulonephritis in thymic stromal lymphopoietin transgenic mice, American Journal of Pathology, 159(6), 2355-69, December 2001 Abstract
  • Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB, Low-grade systemic inflammation in overweight children, Pediatrics, 107(1), E13, Jan 2001 Abstract
  • Wener MH, Daum PR, McQuillan GM, The influence of age, sex, and race on the upper reference limit of serum C-reactive protein concentration, Journal of Rheumatology, 27(10), 2351-9, October 2000 Abstract
  • Neugebauer KM, Merrill JT, Wener MH, Lahita RG, Roth MB, SR proteins are autoantigens in patients with systemic lupus erythematosus. Importance of phosphoepitopes, Arthritis and Rheumatism, 43(8), 1768-78, August 2000 Abstract
  • Mannik M, Merrill CE, Wener MH, Antibodies to human myeloperoxidase in glomerular immune deposits of systemic lupus erythematosus, Lupus, 9(8), 607-13, 2000 Abstract
  • Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB, Elevated C-reactive protein levels in overweight and obese adults, JAMA: The Journal of the American Medical Association, 282(22), 2131-5, 1999 Abstract
  • Chan DW, Kelley CA, Ratliff TL, D''Agostino D, Ritchey J, Lamb DJ, Beck J, Lott N, Wener MH, Daum P, Henkin RE, Kaske DN, Golightly DW, McBride J, Layco G, Ota MK, Tanasijevic MJ, Grudzien C, Woodrum DL, Bray KR, Southwick PC, Gasior GH, Loveland KG, Analytical and clinical performance characteristics of Hybritech''s Tandem-R free PSA assay during a large multicenter clinical trial to determine the clinical utility of percentage of free prostate-s, Clinical Chemistry, 45(10), 1863-5, October 1999 Abstract
  • Hurtado A, Asato C, Escudero E, Stromquist CS, Urcia J, Hurtado ME, de La Cruz S, Wener MH, Zavala R, Johnson RJ, Clinicopathologic correlations in lupus nephritis in Lima, Peru, Nephron, 83(4), 323-30, 1999 Abstract
  • Novak EJ, Blosch CM, Perkins JD, Davis CL, Barr D, McVicar JP, Griffin RS, Farrand AL, Wener M, Marsh CL, Recombinant human tumor necrosis factor receptor Fc fusion protein therapy in kidney transplant recipients undergoing OKT3 induction therapy., Transplantation, 66(12), 1732-5, 27 Dec 1998 Abstract
  • Phillips C, Henderson P J, Mandel L, Kim S, Schaad D, Cooper M, Bien C, Orkand A, Wener M H, Fine J S, Astion M L, Teaching the microscopic examination of urine sediment to second year medical students using the Urinalysis-Tutor computer program., Clinical Chemistry, 44(8 Pt 1), 1692-700, August 1998 Abstract
  • Wood B, Mandel L, Schaad D, Curtis J D, Murray C, Broudy V, Gernsheimer T, Wener M H, LeCrone C N, Astion M L, Teaching the clinical interpretation of peripheral blood smears to a second-year medical school class using the PeripheralBlood-Tutor computer program., American Journal of Clinical Pathology, 109(5), 514-20, May 1998 Abstract
  • Mannik M, Wener M, Treatment of rheumatoid arthritis with a tumor necrosis factor receptor-Fc fusion protein [letter], New England Journal of Medicine, 337(21), 1560; discussion 156, 20 Nov 1997 Abstract
  • Mannik M, Wener M H, Deposition of antibodies to the collagen-like region of C1q in renal glomeruli of patients with proliferative lupus glomerulonephritis., Arthritis and Rheumatism, 40(8), 1504-11, August 1997 Abstract
  • Nixon R G, Wener M H, Smith K M, Parson R E, Strobel S A, Brawer M K, Biological variation of prostate specific antigen levels in serum: an evaluation of day-to-day physiological fluctuations in a well-defined cohort of 24 patients [see comments], Journal of Urology, 157(6), 2183-90, June 1997 Abstract
  • Buchwald D, Wener M H, Pearlman T, Kith P, Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome., Journal of Rheumatology, 24(2), 372-6, February 1997 Abstract
  • Mandel L P, Schaad D C, Cookson B T, Curtis J D, Orkand A R, Wener M H, Lecrone C N, Dewitt D, Astion M L, Evaluation of an interactive computer program to teach gram-stain interpretation., Academic Medicine, 71(10 Suppl), S100-2, October 1996 Abstract
  • Buchwald D, Umali J, Pearlman T, Kith P, Ashley R, Wener M, Postinfectious chronic fatigue: a distinct syndrome?, Clinical Infectious Diseases, 23(2), 385-7, August 1996 Abstract
  • Wener M H, Johnson R J, Sasso E H, Gretch D R, Hepatitis C virus and rheumatic disease [editorial], Journal of Rheumatology, 23(6), 953-9, June 1996 Abstract
  • Astion M L, Wener M H, Hutchinson K, Olsen G B, Orkand A R, Pagliaro L J, A computer program that periodically monitors the ability to interpret the antinuclear antibody test., Clinical Chemistry, 42(5), 836-40, May 1996 Abstract
  • Wener M H, Pagliaro L J, Orkand A R, Olsen G B, Astion M L, ANCA-Tutor: a program that teaches interpretation of an immunofluorescence assay., Md Computing, 13(3), 216-20, Spring 1996 Abstract
  • Shields Laurence E, Uhrich Stefanie B, Komarniski Cathy A, Wener Mark H, Winter Thomas C, Amniotic fluid alpha-fetoprotein determination at the time of genetic amniocentesis: Has it outlived its usefulness?, Journal of Ultrasound in Medicine, 15(11), 735-739, 1996
  • Wener M H, Daum P R, Brawer M K, Variation in measurement of prostate-specific antigen: importance of method and lot variability., Clinical Chemistry, 41(12 Pt 1), 1730-7, December 1995 Abstract
  • Astion M L, Rank J, Wener M H, Torvik P, Schneider J B, Killingsworth L M, Electrophoresis-tutor: an image-based personal computer program that teaches clinical interpretation of protein electrophoresis patterns of serum, urine, and cerebrospinal fluid., Clinical Chemistry, 41(9), 1328-32, September 1995 Abstract
  • Brawer M K, Daum P, Petteway J C, Wener M H, Assay variability in serum prostate-specific antigen determination., Prostate, 27(1), 1-6, July 1995 Abstract
  • Davis C L, Gretch D R, Perkins J D, Harris A W, Wener M H, Alpers C E, Lesniewski R, Lee W, dela Rosa C, Johnson R J, et al, Hepatitis C--associated glomerular disease in liver transplant recipients., Liver Transplantation and Surgery, 1(3), 166-75, May 1995 Abstract
  • Deubner H, Wagnild J P, Wener M H, Alpers C E, Glomerulonephritis with anti-glomerular basement membrane antibody during pregnancy: potential role of the placenta in amelioration of disease., American Journal of Kidney Diseases, 25(2), 330-5, February 1995 Abstract
  • Bates D W, Buchwald D, Lee J, Kith P, Doolittle T, Rutherford C, Churchill W H, Schur P H, Wener M, Wybenga D, et al, Clinical laboratory test findings in patients with chronic fatigue syndrome [see comments], Archives of Internal Medicine, 155(1), 97-103, 9 Jan 1995 Abstract
  • Johnson R J, Willson R, Yamabe H, Couser W, Alpers C E, Wener M H, Davis C, Gretch D R, Renal manifestations of hepatitis C virus infection., Kidney International, 46(5), 1255-63, November 1994 Abstract
  • Rider L G, Miller F W, Targoff I N, Sherry D D, Samayoa E, Lindahl M, Wener M H, Pachman L M, Plotz P H, A broadened spectrum of juvenile myositis. Myositis-specific autoantibodies in children., Arthritis and Rheumatism, 37(10), 1534-8, October 1994 Abstract
  • Astion M L, Hutchinson K, Ching A K, Pagliaro L J, Wener M H, Cytoplasmic tutor: a program for teaching interpretation of a microscope-based laboratory test., Md Computing, 11(5), 301-6, Autumn 1994 Abstract
  • Celum C L, Coombs R W, Jones M, Murphy V, Fisher L, Grant C, Corey L, Inui T, Wener M H, Holmes K K, Risk factors for repeatedly reactive HIV-1 EIA and indeterminate western blots. A population-based case-control study., Archives of Internal Medicine, 154(10), 1129-37, 23 May 1994 Abstract
  • Astion M L, Wener M H, Thomas R G, Hunder G G, Bloch D A, Application of neural networks to the classification of giant cell arteritis., Arthritis and Rheumatism, 37(5), 760-70, May 1994 Abstract
  • Watts D H, Krohn M A, Hillier S L, Wener M H, Kiviat N B, Eschenbach D A, Characteristics of women in preterm labor associated with elevated C-reactive protein levels., Obstetrics and Gynecology, 82(4 Pt 1), 509-14, October 1993 Abstract
  • Astion M L, Wener M H, Thomas R G, Hunder G G, Bloch D A, Overtraining in neural networks that interpret clinical data., Clinical Chemistry, 39(9), 1998-2004, September 1993 Abstract
  • Astion M L, Bloch D A, Wener M H, Neural networks as expert systems in rheumatic disease diagnosis: artificial intelligence or intelligent artifice? [editorial], Journal of Rheumatology, 20(9), 1465-8, September 1993 Abstract
  • Brawer M K, Beatie J, Wener M H, Vessella R L, Preston S D, Lange P H, Screening for prostatic carcinoma with prostate specific antigen: results of the second year., Journal of Urology, 150(1), 106-9, July 1993 Abstract
  • Rider L G, Wener M H, French J, Sherry D D, Mendelman P M, Autoantibody production in Kawasaki syndrome., Clinical and Experimental Rheumatology, 11(4), 445-9, Summer 1993 Abstract
  • Johnson R J, Gretch D R, Yamabe H, Hart J, Bacchi C E, Hartwell P, Couser W G, Corey L, Wener M H, Alpers C E, et al, Membranoproliferative glomerulonephritis associated with hepatitis C virus infection [see comments], New England Journal of Medicine, 328(7), 465-70, 18 Feb 1993 Abstract
  • Hillson J L, Oppliger I R, Sasso E H, Milner E C, Wener M H, Emerging human B cell repertoire. Influence of developmental stage and interindividual variation., Journal of Immunology, 149(11), 3741-52, 1 Dec 1992 Abstract
  • Buchwald D, Garrity D, Pascualy R, Kith P, Ashley R L, Wener M H, Kidd P G, Katon W J, Russo J E, Chronic fatigue syndrome., Toxicology and Industrial Health, 8(4), 157-73, Summer 1992 Abstract
  • Zamber R W, Starkebaum G, Rubin R L, Martens H F, Wener M H, Drug induced systemic lupus erythematosus due to ophthalmic timolol, Journal of Rheumatology, 19(6), 977-9, June 1992 Abstract
  • Buchwald D, Wener M H, Komaroff A L, Anti-neuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities., Arthritis and Rheumatism, 34(11), 1485-6, November 1991 Abstract
  • Watts D H, Krohn M A, Wener M H, Eschenbach D A, C-reactive protein in normal pregnancy., Obstetrics and Gynecology, 77(2), 176-80, February 1991 Abstract
  • Vetto A A, Mannik M, Zatarain-Rios E, Wener M H, Immune deposits in articular cartilage of patients with rheumatoid arthritis have a granular pattern not seen in osteoarthritis., Rheumatology International, 10(1), 13-9, 1990 Abstract

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Last Updated: 6/1/2009

COS Expertise ID #308034
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