Ellen M. Wijsman

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University of Washington
School of Medicine
Medicine
Medical Genetics
Research Professor
University of Washington
School of Public Health and Community Medicine
Biostatistics
Research Professor

Mailing Address

Box 357720
University of Washington
Seattle, Washington 98195-7720
United States

Contact Information

Phone: (206) 543-8987
Fax: (206) 616-1973
wijsman@u.washington.edu

Qualifications

Ph.D., University of Wisconsin-Madison, Genetics, 1981.
B.S., Michigan State University, Biology, 1975.

Expertise and Research Interests

My research is directed towards the development and application of quantitative methods for analysis of human genetic data, including techniques of gene mapping, modelling modes of inheritance, and identifying regions of identify-by-descent through linkage disequilibrium analysis. Application of such methods has allowed me to identify the fine-scale localization of a locus responsible for Werner's syndrome, which, on this basis, has recently been cloned. Similarly, work that my students and I have done lead to the localization of two genes responsible for most early-onset familial Alzheimer's disease (FAD), one of which we subsequently cloned. In addition, our analyses of late onset FAD suggest a complex mode of inheritance, and that the risk of developing disease is affected by several risk factors for atherosclerosis. Other phenotypes on which I am working to identify gene(s) contributing to the trait of interest include dyslexia, autism, schizophrenia, the ALS/Parkinson syndrome of Guam, and abnormal serum lipid and lipoprotein levels.

Computational constraints in analyses of these complex diseases has lead to a search for alternative methods of analysis. I have been working on the development and evaluation of Monte Carlo Markov chain methods of analysis in situations where current methods are computationally impractical, including both complex segregation analysis and multipoint linkage analysis. Our comparisons through simulations and analyses of real data indicates that these methods are in agreement with results obtained with standard procedures.

I also am involved in two outreach programs geared towards bringing NCTM standards in statistics and probability into the elementary school classroom. The first is a small program in collaboration with three of my colleagues from the departments of statistics and biostatistics. We organize week-long summer workshops to provide training for elementary school classroom teacher so that they can teach statistics and probability to elementary school children in their classrooms. These workshopsare open
to any K-6 level teacher in the state of Washington. I am also involved in an NSF-supported systemic initiative in the Seattle School district to train all K-5 level classroom teachers in the district inhands-on science instruction. My role inthis project is to make sure that concepts from statistics and probability get incorporated into the activities so that all elementary school teachers will have some contact and training in these activities.

Keywords

COS Keywords:

Alzheimer's Disease, Autism, Biostatistics, Cardiovascular Biology, Dyslexia, Gene Mapping, Genetics, Gerontology, Schizophrenia, Statistics.

Additional Terms:

ALS, Aging/gerontology, Alzheimer's, Autism, Cardiovascular Biology, Dyslexia, Gene Mapping, Genetic Approaches, Genetics, Linkage Analysis, Maximum Likelihood Methodology, Monte Carlo Markov Chain Methods, Mutation/mutagenesis, Population Genetics, Schizophrenia, Statistics, Werner's Syndrome.

Languages

(Reading, Writing, Speaking)

German: (Functional, Functional, Functional)
Russian: (Functional, Functional, Functional)

Memberships

American Society of Human Genetics
Genetic Society of America (GSA)
International Biometric Society
International Genetic Epidemiology Society

Honors and Awards

1999, Best paper award, Genetic Epidemiology, statistical genetics
1995, Resezarch on Alzheimer's dlsease, Metropolitan Life Foundation, Alzheimer's disease
1978-1981, Predoctoral trainee, National Institutes of Health, Genetics
1975-1978, Predoctoral Fellowship, National Science Foundation, Genetics
1974, Phi Beta Kappa, Michigan State University

Previous Positions

1992-1993, University of Washington, Department of Biostatistics, Adjunct Research Associate Professor
1987-1992, University of Washington, Research Assistant Professor and Adjunct Research Assistant Professor
1984-1987, Stanford University, Department of Genetics, Research Associate
1981-1984, Stanford University, Department of Genetics, Postdoctoral Fellow

Patents

Chromosome 14 and familial Alzheimers disease genetic markers and assays, Patent Number: 5449604, , Institution-owned, United States of America.

Funding Received

  • NIH MH 61399: Mapping genes for schizophrenia in founder populations, Jul 1, 2000 to Jun 30, 2002.
  • NIH HL 30086: Lipoprotein pathophysiology, Apr 1, 1999 to Mar 31, 2004.
  • NIH AG 12019: Cloning of the chromosome 8 Werner Syndrome locus, 9/10/94 to 8/31/99.
  • NIH GM 46255: Methods for Genetic Epidemiology of Complex Traits, 9/1/95 to 11/30/03.
  • NIH HD 35465: Neurobiology and genetics of autism, 7/1/97 to 6/30/02.
  • NIH NS 35932: Mechanism of cell death and injury in neurodegenerative diseases, 7/1/97 to 6/30/01.
  • NIH AG 11762: Genomic analysis of Alzheimer's disease genes, 6/1/94 to 4/30/03.
  • NIH AG 05136: Alzheimer's Disease Research Center. Project 1: Genetic studies of familial Alzheimer's disease, 5/1/95 to 4/30/05.
  • NIH AG 05136: Alzheimer's Disease Research Center. Core F: Data Management, 5/1/95 to 4/30/05.
  • NIH AG 14382: Genome analysis of neurodegenerative diseases in Micronesia, 3/1/97 to 2/28/02.
  • NIH HD 33812: Learning disabilities: links to schools and biology, 3/1/96 to 11/30/05.
  • Metropolitan Life Foundation: Metropolitan Life Award, 11/1/95 to 12/30/99.

Publications

  • Wijsman EM, Nur N, On estimating the proportion of variance in a phenotypic trait attributable to a measured locus, Human Heredity, 51(3), 145-9, 2001 Abstract
  • Chapman NC, Leutenegger A-L, Badzioch MD, Bogdan M, Conlon EM, Daw EW, Gagnon F, Li N, Maia JM, Wijsman EM, Thompson EA, The importance of connections: joining components of the Hutterite pedigree, Genetic Epidemiology, S230-S235, 2001
  • Chapman NC, Wijsman EM, Introduction: Linkage analysis in the Hutterites, Genetic Epidemiology, 21, S222-S223, 2001
  • Wijsman EM Almasy L, Amos CI, Borecki IB, Falk CT, King TM, Martinez MM, Meyers DA, Neuman RJ, Olson JM, Rich SS, Spence MA, Thomas DC, Vieland VJ, Witte JS, MacCluer JW, Genetic analysis workshop 12: Analysis of complex genetic traits: applications to asthma and simulated data, Genetic Epidemiology, 21, 2001
  • Hsu L, Wijsman EM, Berninger VW, Thomson JB, Raskind WH, Familial aggregation of dyslexia phenotypes II: Paired correlated measures, American Journal of Medical Genetics, (in press), 2001
  • Daw EW, Thompson EA, Wijsman EM, Bias in multipoint linkage analysis arising from map misspecification, Genetic Epidemiology, 19(4), 366-80, December 2000 Abstract
  • Raskind WH, Hsu L, Berninger VW, Thomson JB, Wijsman EM, Familial aggregation of dyslexia phenotypes, Behavior Genetics, 30(5), 385-96, September 2000 Abstract
  • Saavedra-Matiz CA, Chapman NH, Wijsman EM, Horowitz SH, Rosen DR, Linkage of hereditary distal myopathy with desmin accumulation to 2q, Human Heredity, 50(3), 166-70, 2000 Abstract
  • Daw EW, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD, Wijsman EM, The number of trait loci in late-onset Alzheimer's disease, American Journal of Human Genetics, 66(1), 196-204, Jan 2000
  • Warwick Daw E, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD, Wijsman EM, The number of trait loci in late-onset Alzheimer disease., American Journal of Human Genetics, 66(1), 196-204, 2000 Abstract
  • Wijsman EM, Peterson D, Leutenegger A-L, Thomson JB, Goddard KAB, Hsu L, Berninger VB, Raskind WH, Segregation analysis of phenotypic components of learning disabilities, I. Nonword memory and digit span, The American Journal of Human Genetics, 67, 631-646, 2000
  • Daw EW, Heath SC, Wijsman EM, Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees., American Journal of Human Genetics, 64(3), 839-51, March 1999 Abstract
  • Hokanson JE, Brunzell JD, Jarvik GP, Wijsman EM, Austin MA, Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency., American Journal of Human Genetics, 64(2), 608-18, February 1999 Abstract
  • Schaid DJ, Buetow K, Weeks DE, Wijsman E, Guo S-W, Ott J, Dahl C, Discovery of cancer usceptibility genes: study designs, analytic approaches, and trends in technology, Journal of the National Cancer Institute. Monographs, 26, 1-16, 1999
  • Sjoberg G, Saavedra-Matiz CA, Rosen DR, Wijsman EM, Borg K, Horowitz SH, Sejersen T, A missense mutation in the desmin rod domain is associated with autosomal dominant distal myopathy, and exerts a dominant negative effect on filament formation, Human Molecular Genetics, 8, 2191-2198, 1999
  • Austin MA, Stephens K, Walden CE, Wijsman E, Linkage analysis of candidate genes and the small, dense low-density lipoprotein phenotype, Atherosclerosis., 142, 79-87, 1999
  • Daw EW, Kumm J, Snow GL, Thompson EA, Wijsman EM, Monte Carlo Markov chain methods for genome screening., Genetic Epidemiology, 17 Suppl 1, S133-8, 1999 Abstract
  • Chapman NH, Wijsman EM, Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility., American Journal of Human Genetics, 63(6), 1872-85, December 1998 Abstract
  • Poorkaj P, Bird T D, Wijsman E, Nemens E, Garruto R M, Anderson L, Andreadis A, Wiederholt W C, Raskind M, Schellenberg G D, Tau is a candidate gene for chromosome 17 frontotemporal dementia., Annals of Neurology, 43(6), 815-25, June 1998 Abstract
  • Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD, Tau is a candidate gene for chromosome 17 frontotemporal dementia [published erratum appears in Ann Neurol 1998 Sep;44\(3\):428, Annals of Neurology, 43(6), 815-25, 1998 Abstract
  • Wijsman E M, Brunzell J D, Jarvik G P, Austin M A, Motulsky A G, Deeb S S, Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex., Arteriosclerosis, Thrombosis, and Vascular Biology, 18(2), 215-26, February 1998 Abstract
  • Snow G L, Wijsman E M, Pedigree analysis package (PAP) vs. MORGAN: model selection and hypothesis testing on a large pedigree., Genetic Epidemiology, 15(4), 355-69, 1998 Abstract
  • Li H, Thompson E A, Wijsman E M, Semiparametric estimation of major gene effects for age of onset., Genetic Epidemiology, 15(3), 279-98, 1998 Abstract
  • Raskind W H, Conrad E U 3rd, Matsushita M, Wijsman E M, Wells D E, Chapman N, Sandell L J, Wagner M, Houck J, Evaluation of locus heterogeneity and EXT1 mutations in 34 families with hereditary multiple exostoses., Human Mutation, 11(3), 231-9, 1998 Abstract
  • Edland S D, Wijsman E M, Schoder-Ehri G L, Leverenz J B, Little evidence of reduced survival to adulthood of apoE epsilon4 homozygotes in Down's syndrome., Neuroreport, 8(16), 3463-5, 10 Nov 1997 Abstract
  • Bird T D, Wijsman E M, Nochlin D, Leehey M, Sumi S M, Payami H, Poorkaj P, Nemens E, Rafkind M, Schellenberg G D, Chromosome 17 and hereditary dementia: linkage studies in three non-Alzheimer families and kindreds with late-onset FAD., Neurology, 48(4), 949-54, April 1997 Abstract
  • Yu C E, Oshima J, Wijsman E M, Nakura J, Miki T, Piussan C, Matthews S, Fu Y H, Mulligan J, Martin G M, Schellenberg G D, Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group., American Journal of Human Genetics, 60(2), 330-41, February 1997 Abstract
  • Graham J, Chapman N H, Goddard K A, Goode E L, Wijsman E M, Jarvik G P, Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees., Genetic Epidemiology, 14(6), 999-1004, 1997 Abstract
  • Wijsman E M, Amos C I, Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions., Genetic Epidemiology, 14(6), 719-35, 1997 Abstract
  • Heath S C, Snow G L, Thompson E A, Tseng C, Wijsman E M, MCMC segregation and linkage analysis., Genetic Epidemiology, 14(6), 1011-6, 1997 Abstract
  • Marcovina S M, Albers J J, Wijsman E, Zhang Z, Chapman N H, Kennedy H, Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans., Journal of Lipid Research, 37(12), 2569-85, December 1996 Abstract
  • Nakura J, Miki T, Ye L, Mitsuda N, Zhao Y, Kihara K, Yu C E, Oshima J, Fukuchi K I, Wijsman E M, Schellenberg G D, Martin G M, Murano Si, Hashimoto K, Fujiwara Y, Ogihara T, Narrowing the position of the Werner syndrome locus by homozygosity analysis-extension of homozygosity analysis., Genomics, 36(1), 130-41, 15 Aug 1996 Abstract
  • Edland S D, Silverman J M, Peskind E R, Tsuang D, Wijsman E, Morris J C, Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance., Neurology, 47(1), 254-6, July 1996 Abstract
  • Goddard K A, Yu C E, Oshima J, Miki T, Nakura J, Piussan C, Martin G M, Schellenberg G D, Wijsman E M, Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers., American Journal of Human Genetics, 58(6), 1286-302, June 1996 Abstract
  • Yu C E, Oshima J, Fu Y H, Wijsman E M, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin G M, Mulligan J, Schellenberg G D, Positional cloning of the Werner's syndrome gene, Science, 272(5259), 258-62, 12 Apr 1996 Abstract
  • Payami H, Zareparsi S, Montee K R, Sexton G J, Kaye J A, Bird T D, Yu C E, Wijsman E M, Heston L L, Litt M, Schellenberg G D, Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women., American Journal of Human Genetics, 58(4), 803-11, April 1996 Abstract
  • Olshen A B, Wijsman E M, Pedigree analysis package vs. MIXD: fitting the mixed model on a large pedigree., Genetic Epidemiology, 13(1), 91-106, 1996 Abstract
  • Jarvik G, Larson E B, Goddard K, Schellenberg G D, Wijsman E M, Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample [published erratum appears in Am J Hum Genet 1996 Mar;58(3):648], American Journal of Human Genetics, 58(1), 191-200, January 1996 Abstract
  • Goddard K.A.B., Yu C-E, Oshima J., Miki T., Nakura J., Piussan C., Martin G.M., Schellenberg G.D., Wijsman E.M., and members of the International, Towards localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping:, American Journal of Human Genetics, 1286-1302, 1996
  • Levy-Lahad E, Lahad A, Wijsman E M, Bird T D, Schellenberg G D, Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease., Annals of Neurology, 38(4), 678-80, October 1995 Abstract
  • Levy-Lahad E, Wijsman E M, Nemens E, Anderson L, Goddard K A, Weber J L, Bird T D, Schellenberg G D, A familial Alzheimer's disease locus on chromosome 1, Science, 269(5226), 970-3, 18 Aug 1995 Abstract
  • Jarvik G P, Wijsman E M, Kukull W A, Schellenberg G D, Yu C, Larson E B, Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study., Neurology, 45(6), 1092-6, June 1995 Abstract
  • Stephens K, Zlotogorski A, Smith L, Ehrlich P, Wijsman E, Livingston R J, Sybert V P, Epidermolysis bullosa simplex: a keratin 5 mutation is a fully dominant allele in epidermal cytoskeleton function., American Journal of Human Genetics, 56(3), 577-85, March 1995 Abstract
  • Querfurth H W, Wijsman E M, St George-Hyslop P H, Selkoe D J, Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family., Brain research. Molecular Brain Research, 28(2), 319-37, February 1995 Abstract
  • Goddard K A, Jarvik G P, Graham J, McNeney B, Hsu L, Siegmund K, Grosser S, Olson J, Wijsman E M, Analysis of quantitative risk factors for a common oligogenic disease., Genetic Epidemiology, 12(6), 759-64, 1995 Abstract
  • Jarvik G P, Brunzell J D, Austin M A, Krauss R M, Motulsky A G, Wijsman E, Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype., Arteriosclerosis and Thrombosis, 14(11), 1687-94, November 1994 Abstract
  • Nakura J, Wijsman E M, Miki T, Kamino K, Yu C E, Oshima J, Fukuchi K, Weber J L, Piussan C, Melaragno M I, et al, Homozygosity mapping of the Werner syndrome locus (WRN)., Genomics, 23(3), 600-8, October 1994 Abstract
  • Lin S, Thompson E, Wijsman E, An algorithm for Monte Carlo estimation of genotype probabilities on complex pedigrees., Annals of Human Genetics, 58 ( Pt 4), 343-57, October 1994 Abstract
  • Jarvik G P, Wijsman E M, Alzheimer's disease and the family effect, Nature Genetics, 8(2), 115, October 1994 Abstract
  • Olson J M, Wijsman E M, Design and sample-size considerations in the detection of linkage disequilibrium with a disease locus., American Journal of Human Genetics, 55(3), 574-80, September 1994 Abstract
  • Palmer S E, Scherer S W, Kukolich M, Wijsman E M, Tsui L C, Stephens K, Evans J P, Evidence for locus heterogeneity in human autosomal dominant split hand/split foot malformation, American Journal of Human Genetics, 55(1), 21-6, July 1994 Abstract
  • Payami H, Montee K R, Kaye J A, Bird T D, Yu C E, Wijsman E M, Schellenberg G D, Alzheimer's disease, apolipoprotein E4, and gender, Jama, 271(17), 1316-7, 4 May 1994 Abstract
  • Yu C E, Payami H, Olson J M, Boehnke M, Wijsman E M, Orr H T, Kukull W A, Goddard K A, Nemens E, White J A, et al, The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease., American Journal of Human Genetics, 54(4), 631-42, April 1994 Abstract
  • Lin S, Thompson E, Wijsman E, Finding noncommunicating sets for Markov chain Monte Carlo estimations on pedigrees., American Journal of Human Genetics, 54(4), 695-704, April 1994 Abstract
  • Palmer S E, Dale D C, Livingston R J, Wijsman E M, Stephens K, Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5., Human Genetics, 93(2), 195-7, February 1994 Abstract
  • Commenges D, Olson J, Wijsman E, The weighted rank pairwise correlation statistic for linkage analysis: simulation study and application to Alzheimer's disease., Genetic Epidemiology, 11(2), 201-12, 1994 Abstract
  • Bonnycastle L L, Yu C E, Wijsman E M, Orr H T, Patterson D, Clancy K P, Goddard K A, Alonso M E, Nemens E, White J A, et al, The c-fos gene and early-onset familial Alzheimer's disease., Neuroscience Letters, 160(1), 33-6, 17 Sep 1993 Abstract
  • Schellenberg G D, Payami H, Wijsman E M, Orr H T, Goddard K A, Anderson L, Nemens E, White J A, Alonso M E, Ball M J, et al, Chromosome 14 and late-onset familial Alzheimer disease (FAD)., American Journal of Human Genetics, 53(3), 619-28, September 1993 Abstract
  • Stephens K, Sybert V P, Wijsman E M, Ehrlich P, Spencer A, A keratin 14 mutational hot spot for epidermolysis bullosa simplex, Dowling-Meara: implications for diagnosis, Journal of Investigative Dermatology, 101(2), 240-3, August 1993 Abstract
  • Wijsman E M, Genetic analysis of Alzheimer's disease: a summary of contributions to GAW8., Genetic Epidemiology, 10(6), 349-60, 1993 Abstract
  • Wijsman E M, Bird T D, Martin G M, Schellenberg G D, The Seattle Alzheimer's disease data set., Genetic Epidemiology, 10(6), 365-9, 1993 Abstract
  • Thompson E A, Lin S, Olshen A B, Wijsman E M, Monte Carlo analysis on a large pedigree., Genetic Epidemiology, 10(6), 677-82, 1993 Abstract
  • Olson J M, Wijsman E M, Linkage between quantitative trait and marker loci: methods using all relative pairs., Genetic Epidemiology, 10(2), 87-102, 1993 Abstract
  • Lin S, Thompson E, Wijsman E, Achieving irreducibility of the Markov chain Monte Carlo method applied to pedigree data., Ima Journal of Mathematics Applied In Medicine and Biology, 10(1), 1-17, 1993 Abstract
  • Jarvik G P, Wijsman E, Little R E, Albers J J, Motulsky A G, Brunzell J D, Host and environmental effects on plasma apolipoprotein B., International Journal of Clinical and Laboratory Research, 23(4), 215-20, 1993 Abstract
  • Kamino K, Orr H T, Payami H, Wijsman E M, Alonso M E, Pulst S M, Anderson L, O'dahl S, Nemens E, White J A, et al, Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region., American Journal of Human Genetics, 51(5), 998-1014, November 1992 Abstract
  • Schellenberg G D, Bird T D, Wijsman E M, Orr H T, Anderson L, Nemens E, White J A, Bonnycastle L, Weber J L, Alonso M E, et al, Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14., Science, 258(5082), 668-71, 23 Oct 1992 Abstract
  • Schellenberg G D, Martin G M, Wijsman E M, Nakura J, Miki T, Ogihara T, Homozygosity mapping and Werner's syndrome, Lancet, 339(8799), 1002, 18 Apr 1992 Abstract
  • Deeb S S, Failor R A, Brown B G, Brunzell J D, Albers J J, Motulsky A G, Wijsman E, Association of apolipoprotein B gene variants with plasma apoB and low density lipoprotein (LDL) cholesterol levels., Human Genetics, 88(4), 463-70, February 1992 Abstract
  • Schellenberg G D, Boehnke M, Wijsman E M, Moore D K, Martin G M, Bird T D, Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease., Annals of Neurology, 31(2), 223-7, February 1992 Abstract
  • Blossey H, Guo S W, McKnight B, Tierney C, Thompson E, Wijsman E, Linkage analysis of malignant melanoma with the chromosome 1 markers D1S47 and PND., Cytogenetics and Cell Genetics, 59(2-3), 182-4, 1992 Abstract
  • Austin M A, Horowitz H, Wijsman E, Krauss R M, Brunzell J, Bimodality of plasma apolipoprotein B levels in familial combined hyperlipidemia., Atherosclerosis, 92(1), 67-77, January 1992 Abstract
  • Wijsman E M, Recurrence risk of a new dominant mutation in children of unaffected parents., American Journal of Human Genetics, 48(4), 654-61, April 1991 Abstract
  • Schellenberg G D, Pericak-Vance M A, Wijsman E M, Moore D K, Gaskell P C Jr, Yamaoka L A, Bebout J L, Anderson L, Welsh K A, Clark C M, et al, Linkage analysis of familial Alzheimer disease, using chromosome 21 markers., American Journal of Human Genetics, 48(3), 563-83, March 1991 Abstract
  • Raskind W H, Wijsman E, Pagon R A, Cox T C, Bawden M J, May B K, Bird T D, X-linked sideroblastic anemia and ataxia: linkage to phosphoglycerate kinase at Xq13., American Journal of Human Genetics, 48(2), 335-41, February 1991 Abstract
  • Austin M A, Wijsman E, Guo S W, Krauss R M, Brunzell J D, Deeb S, Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia., Genetic Epidemiology, 8(5), 287-97, 1991 Abstract
  • Martin G M, Schellenberg G D, Wijsman E M, Bird T D, Alzheimer's disease. Dominant susceptibility genes, Nature, 347(6289), 124, 13 Sep 1990 Abstract
  • Bird T D, Lampe T H, Nemens E J, Sumi S M, Nochlin D, Schellenberg G D, Wijsman E M, Characteristics of familial Alzheimer's disease in nine kindreds of Volga German ancestry., Progress In Clinical and Biological Research, 317, 229-34, 1989 Abstract
  • Schellenberg G D, Bird T D, Wijsman E M, Moore D K, Martin G M, The genetics of Alzheimer's disease., Biomedicine and Pharmacotherapy, 43(7), 463-8, 1989 Abstract
  • Jarvik G.P., Larson E.B., Goddard K., Kukull W.A., Schellenberg G.D., Wijsman E.M. (1996) Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample. American Journal of Human Genetics 58:191-200
  • Levy-Lahad E., Wijsman E.M., Nemens E., Anderson L., Goddard K.A.B., Weber J.L., Bird T.D., Schellenberg G.D. (1995) A familial Alzheimer's disease locus on chromosome 1. Science 269:970-973
  • Olson J.M., Wijsman E.M. (1994) Design and sample size considerations in the detection of linkage disequilibrium with a disease locus. American Journal of Human Genetics 55:574-580
  • Lin S., Thompson E., Wijsman E.M. (1994) An algorithm for Monte Carlo estimation of genotype probabilities on complex pedigrees. Annals of Human Genetics 58:343-357

Profile Details

Last Updated: 10/29/2001

COS Expertise ID #308664
Reference this profile directly: http://myprofile.cos.com/wijsman