William H. Schubach

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VA Puget Sound Health Care System
Medicine
Oncology
Medical Oncology
DirectorAppointed: 1993
University of Washington
School of Medicine
Medicine
Oncology
Associate ProfessorAppointed: 1994
Fred Hutchinson Cancer Research Center
Clinical Research Division
Professional Headshot of William H. Schubach

Mailing Address

Box 358280
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 764-2709
Fax: (206) 764-2851
wschu@u.washington.edu

Qualifications

M.D., Columbia University, 1974.
Ph.D., University of California, Santa Cruz, 1971.

Expertise and Research Interests

Epstein-Barr virus (EBV)is implicated in several human cancers but is causative of polyclonal and monoclonal B cell malignancies that occur in immunosupressed people. My laboratory is studying the multiprotein complexes involved in B cell immortaliztionby EBV with emphasis on the role played by the Epstein-Barr nuclear protein 2. We are studying the role of the human SWI/SNF chromatin remodeling complex in transcription regulation by EBV. In addition, we have found that EBNA2 modulates the activity ofa number of other proteins involved in gene expression and cell division. Our lab is studying these interactions and their roles in virus-induced B cell immortalization.

Keywords

COS Keywords:

Cancer Biology, Cell Biology, Epstein-Barr Virus, Lymphocytes, Oncology, Tumors.

Additional Terms:

Cancer, Cell Biology: Transformation, Chromatin Remodeling, Chromatin Structure, Epstein-Barr Virus, Lymphocyte Transformation, Oncology: Therapy and Treatment, Tumor Biology.

Memberships

American Society of Hematology
American Society of Microbiology

Funding Received

  • National Institutes of Health (NIH): Chromatin Remodeling and Viral Transformation, $375,000, Aug 1, 2000 to Jul 31, 2003.
  • Department of Veterans Affairs-Merit Review: Control Factors in Lymphocyte Development, $420,000, Apr 1, 2000 to Mar 31, 2003.

Publications

  • Kwiatkowski, B., Ragoczy, T., Ehly, J., Schubach, W.H (2004) Identification and cloning of a novel chromatin associated protein partner of Epstein-Barr nuclear protein 2, Experimental Cell Research, 300, 223-233
  • Kwiatkowski, B., Chen, S-Y. J., Schubach, W.H (2004) CKII site in Epstein-Barr virus nuclear protein 2 controls binding to hSNF5/Ini1 and is important for growth transformation, Journal of Virology, 78, 6067-6072
  • Wu, D.Y., D. C. Tkachuck, R. S. Roberson, W. H. Schubach (2002) The human SNF5/Ini1 protein is a regulatory protein for PP1 phosphatase and mediates growth suppression by GADD34, J. Biol. Chem, 277, 27706-27715
  • Yang, L., L. Xia, Wu, D.Y., Wang, H. Chansky, H.A., Schubach, W.H., Hickstein, D. D., Zhang, Y (2002) Molecular Cloning of ESET, a novel histone H3-specific methyltransferase, Oncogene, 21, 148-152
  • Wu DY, Krumm A, Schubach WH, Promoter-specific targeting of human SWI-SNF complex by Epstein-Barr virus nuclear protein 2, Journal of Virology, 74(19), 8893-903, October 2000 Abstract
  • Becker JL, Miller F, Nuovo GJ, Josepovitz C, Schubach WH, Nord EP, Epstein-Barr virus infection of renal proximal tubule cells: possible role in chronic interstitial nephritis, Journal of Clinical Investigation, 104(12), 1673-81, December 1999 Abstract
  • Grundhoff AT, Kremmer E, Tureci O, Glieden A, Gindorf C, Atz J, Mueller-Lantzsch N, Schubach WH, Grasser FA, Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C, Journal of Biological Chemistry, 274(27), 19136-44, July 1999 Abstract
  • Shilatifard A, Duan DR, Haque D, Florence C, Schubach WH, Conaway JW, Conaway RC, ELL2, a new member of an ELL family of RNA polymerase II elongation factors, Proceedings of the National Academy of Sciences (USA), 94(8), 3639-43, April 1997 Abstract
  • Schubach WH, Horvath G, LeVea C, Tierney J, Chromatin structure of the lymphocyte Fc epsilon receptor gene (CD23): identification of an upstream transcriptional enhancer, Journal of Immunology, 158(5), 2228-35, March 1997 Abstract
  • Wu DY, Kalpana GV, Goff SP, Schubach WH, Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1, Journal of Virology, 70(9), 6020-8, September 1996 Abstract
  • Sauder C, Gotzinger N, Schubach WH, Horvath GC, Kremmer E, Krebs A, Konig S, Zimber Strobl U, Mueller Lantzsch N, Grasser FA, Mutational analysis of the Epstein-Barr virus nuclear antigen 2 by far-Western blotting and DNA-binding studies, Journal of General Virology, 77 ( Pt 5), 991-6, May 1996 Abstract
  • Tsui S, Schubach WH, Epstein-Barr virus nuclear protein 2A forms oligomers in vitro and in vivo through a region required for B-cell transformation, Journal of Virology, 68(7), 4287-94, July 1994 Abstract
  • Luft BJ, Mudri S, Jiang W, Dattwyler RJ, Gorevic PD, Fischer T, Munoz P, Dunn JJ, Schubach WH, The 93-kilodalton protein of Borrelia burgdorferi: an immunodominant protoplasmic cylinder antigen, Infection and Immunity, 60(10), 4309-21, October 1992 Abstract
  • Schubach WH, Horvath G, Spoth B, Hearing JC, Expression of Epstein-Barr virus nuclear antigen 2 in insect cells from a baculovirus vector, Virology, 185(1), 428-31, November 1991 Abstract
  • Schubach WH, Mudri S, Dattwyler RJ, Luft BJ, Mapping antibody-binding domains of the major outer surface membrane protein (OspA) of Borrelia burgdorferi, Infection and Immunity, 59(6), 1911-5, June 1991 Abstract

Profile Details

Last Updated: 2/2/2007

COS Expertise ID #135380
Reference this profile directly: http://myprofile.cos.com/wschu