Dr. Yukari C. Manabe

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Johns Hopkins University
School of Medicine
Medicine
Infectious Diseases
Assistant ProfessorAppointed: 1999
Johns Hopkins University
Bloomberg School of Public Health
International Health
Johns Hopkins University
Bloomberg School of Public Health
Molecular Microbiology and Immunology

Mailing Address

720 Rutland Street
Room 11147
Baltimore, Maryland 21205
United States

Contact Information

Phone: (410) 614-6600
Fax: (410) 614-9775
ymanabe@jhmi.edu

Qualifications

M.D., Columbia University, Medicine, 1991.
B.S., Yale University, Molecular Biology & Biophysics, 1987.

Expertise and Research Interests

Aerosol Model of Tuberculosis, rabbit, mouse
tuberculosis immunopathogenesis

Other Expertise

Animal Models of Tuberculosis
Molecular Pathogenesis of Tuberculosis
HIV/TB Clinical Care
Immune Reconstitution Inflammatory Syndrome

Keywords

COS Keywords:

Infectious Diseases Or Agents, Pathogenesis, Tuberculosis.

Additional Terms:

Infectious Diseases, Pathogenesis, Tuberculosis.

Memberships

ASM International
American Federation for Medical Research
Infectious Diseases Society of America

Publications

  • Manabe YC, Hatem CL, Kesavan AK, Durack J, Murphy JR (Sep 2005) Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosis., Infection and Immunity, 73 (9), 5988-94 Abstract
  • Dorman SE, Hatem CL, Tyagi S, Aird K, Lopez-Molina J, Pitt ML, Zook BC, Dannenberg AM Jr, Bishai WR, Manabe YC (Mar 2004) Susceptibility to tuberculosis: clues from studies with inbred and outbred New Zealand White rabbits., Infection and Immunity, 72 (3), 1700-5 Abstract
  • Geiman DE, Kaushal D, Ko C, Tyagi S, Manabe YC, Schroeder BG, Fleischmann RD, Morrison NE, Converse PJ, Chen P, Bishai WR (Mar 2004) Attenuation of late-stage disease in mice infected by the Mycobacterium tuberculosis mutant lacking the SigF alternate sigma factor and identification of SigF-dependent genes by microarray analysis., Infection and Immunity, 72 (3), 1733-45 Abstract
  • Scott CP, Kumar N, Bishai WR, Manabe YC (Feb 2004) Short report: modulation of Mycobacterium tuberculosis infection by Plasmodium in the murine model., The American Journal of Tropical Medicine and Hygiene, 70 (2), 144-8 Abstract
  • Manabe YC, Dannenberg AM Jr, Tyagi SK, Hatem CL, Yoder M, Woolwine SC, Zook BC, Pitt ML, Bishai WR (Oct 2003) Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis., Infection and Immunity, 71 (10), 6004-11 Abstract
  • Ando M, Manabe YC, Converse PJ, Miyazaki E, Harrison R, Murphy JR, Bishai WR (May 2003) Characterization of the role of the divalent metal ion-dependent transcriptional repressor MntR in the virulence of Staphylococcus aureus., Infection and Immunity, 71 (5), 2584-90 Abstract
  • Scott CP, Dos Anjos Filho L, De Queiroz Mello FC, Thornton CG, Bishai WR, Fonseca LS, Kritski AL, Chaisson RE, Manabe YC (Sep 2002) Comparison of C(18)-carboxypropylbetaine and standard N-acetyl-L-cysteine-NaOH processing of respiratory specimens for increasing tuberculosis smear sensitivity in Brazil., Journal of Clinical Microbiology, 40 (9), 3219-22 Abstract
  • Kaushal D, Schroeder BG, Tyagi S, Yoshimatsu T, Scott C, Ko C, Carpenter L, Mehrotra J, Manabe YC, Fleischmann RD, Bishai WR (Jun 2002) Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH., Proceedings of the National Academy of Sciences of the United States of America., 99 (12), 8330-5 Abstract
  • Manabe YC, Scott CP, Bishai WR (Mar 2002) Naturally attenuated, orally administered Mycobacterium microti as a tuberculosis vaccine is better than subcutaneous Mycobacterium bovis BCG., Infection and Immunity, 70 (3), 1566-70 Abstract
  • Manabe YC, Bishai WR (Dec 2000) Latent Mycobacterium tuberculosis-persistence, patience, and winning by waiting., Nature Medicine, 6 (12), 1327-9 Abstract
  • Manabe YC, Dannenberg AM Jr, Bishai WR (Feb 2000) What we can learn from the Mycobacterium tuberculosis genome sequencing projects., The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease., 4 (2 Suppl 1), S18-23 Abstract
  • Manabe YC, Chen JM, Ko CG, Chen P, Bishai WR (Dec 1999) Conditional sigma factor expression, using the inducible acetamidase promoter, reveals that the Mycobacterium tuberculosis sigF gene modulates expression of the 16-kilodalton alpha-crystallin homologue., Journal of Bacteriology, 181 (24), 7629-33 Abstract
  • Manabe YC, Saviola BJ, Sun L, Murphy JR, Bishai WR (Oct 1999) Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor., Proceedings of the National Academy of Sciences of the United States of America., 96 (22), 12844-8 Abstract
  • Lumadue JA, Manabe YC, Moore RD, Belitsos PC, Sears CL, Clark DP (Dec 1998) A clinicopathologic analysis of AIDS-related cryptosporidiosis., Aids (london, England), 12 (18), 2459-66 Abstract
  • Manabe YC, Clark DP, Moore RD, Lumadue JA, Dahlman HR, Belitsos PC, Chaisson RE, Sears CL (Sep 1998) Cryptosporidiosis in patients with AIDS: correlates of disease and survival., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 27 (3), 536-42 Abstract
  • Manabe YC, Vinetz JM, Moore RD, Merz C, Charache P, Bartlett JG (Dec 1995) Clostridium difficile colitis: an efficient clinical approach to diagnosis., Annals of Internal Medicine, 123 (11), 835-40 Abstract
  • Canellakis ZN, Marsh LL, Manabe YC, Infante AA, Bondy PK, Scalise FW (Nov 1989) Spermidine labels proteins during sea urchin embryogenesis., Biochemistry International, 19 (5), 969-76 Abstract

Profile Details

Last Updated: 8/24/2007

COS Expertise ID #1209204
Reference this profile directly: http://myprofile.cos.com/ymanabe