Dr. Timothy R. Zacharewski

RECEPTOR MEDIATED TOXICOLOGY:
In my laboratory, the primary focus is on mechanistic toxicology which evolves elucidating how a chemical elicits its adverse effects. More, specifically, we are interested in exploring how chemicals cause changes in gene expression that result in hormone-dependent cancers and compromised reproductive fitness. Research efforts are currently divided into the following two areas:

1.--ENDOCRINE DISRUPTION--examine receptor-mediated endocrine disrupting activities of chemicals and natural products in humans and wildlife.

2.--TOXICOGENOMICS--assess the effects of developmental exposure to endocrine disruptors on fertility and reproductive tissue gene expression profiles using gene expression array technology developed asa result of the Human Genome Project.

Postdoctoral Training - INSERM U.184, CNRS-LGME, Institut de Chimie Bioloique-Faculte de Medecine, 11, Rue Humann, 67085 Strasbourg, France--Medical Research Council of Canada (MRC) Postdoctoral Fellow

Continuing education:
1988-1989--Concepts inTumorBiology I ans II, University of Texas System Cancer Center, Science Park-Research Division at Smithville, TX

1988--Molecular Endocrinology Workshop, Department of Cell Biology, Baylor College of Medicine, Houston, TX

1988--Recombinant DNA Techniques Workshop, Bethesda Research Laboratories-Life Technologies, Inc., Huntsville, TX

1992--Molecular Yeast Genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

1992--EMBO Molecular Genetics of Yeast, Biozentrum, Basil, Switzerland

1993--PCR Techniques, Catholic University of America, Washington, DC

1994--The Use of Molecular Biology in Toxicology, 33rd Society of Toxicology Annual Meeting, Dallas, TX

1995--New Endpoints in Development and Reproductive Regulatory Studies:MethodsforSuccess, Continuing Education Course, 34th Society of Toxicology Annual Meeting, Baltimore, MD

1996--Applications of PCR Technologies to Molecular Toxicology, 35th Society of Toxicology Annual Meeting, Anaheim, CA

1996--The Female reproductiveSystem-How to Assess Potential Toxicity, 35th Society of Toxicology Annual Meeting, Anaheim, CA

Faculty Development:
1995--Teaching at the University Level. Educational Development Office, University of Western Ontario, London, Ont.

1998--ProblemBased Learning (PBL) Faculty Development Workshop, College of Human Medicine, Michigan State University

Comparative in vitro and in vivo gene expresion profiles elicited by pharmaceuticals, natural products, undustriasl chemicals, pesticides and environmental contaminants found in food using human, mouse and rat microarray technologies.