Lue Ping Zhao

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Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program in Biostatistics
Full MemberAppointed: 2001
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program in Epidemiology
Full MemberAppointed: 2001
University of Washington
School of Public Health and Community Medicine
Biostatistics
Affiliated ProfessorAppointed: 2001
Fred Hutchinson Cancer Research Center
Genetic Epidemiology and Microarray Technology Affinity Group
HeadAppointed: 1999

Mailing Address

Box 358080
MP-381
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 667-6927
Fax: (206) 667-2437
lzhao@zebra.fhcrc.org

Qualifications

Ph.D., University of Washington, Biostatistics, 1989.
M.S., University of Washington, Biostatistics, 1987.
M.S., Shanghai Medical University, Statistics in Health Science, 1985.
B.S., Shanghai University of Science and Technology, Computer Science, 1982.

Keywords

COS Keywords:

Biostatistics, Epidemiology, Genomics, Proteomics, Public Health, Statistics.

Additional Terms:

Functional Genomics, Genomics, Microarray Technologies, Proteomics, Statistical Methods for High Throughput Data Analysis.

Languages

(Reading, Writing, Speaking)

Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)

Memberships

American Association for the Advancement of Science
American Society of Human Genetics
American Statistical Association

Previous Positions

1995-2001, Associate Professor, University of Washington, Biostatistics; Epidemiology
1995-2001, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics; Epidemiology
1993-1995, Assistant Professor, University of Washington, Biostatistics; Epidemiology
1993-1995, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics; Epidemiology
1990-1993, Assistant Researcher, University of Hawaii, Cancer Research Center, Epidemiology Program
1990-1993, Adjunct Assistant Professor, University of Hawaii, School of Public Health, Biostatistics
1990, Research Fellow, Harvard University, School of Public Health, Biostatistics
1989-1990, Staff Scientist, Fred Hutchinson Cancer Research Center, Public Health Sciences Division

Publications

  • Guo Y, Breeden L, Fan W, Zhao LP, Eaton DL, Zarbl H, Analysis of cellular responses to aflatoxin B1 in yeast expressing human cytochrome P4501A2 using cDNA microarrays, Mutation Research, 593:121-142, 2006
  • Chien JW, Zhao LP, Hansen JA, Parimon T, Clark J, Genetic Variation in Bacericidal/Permeability Increasing Protein Influences the Risk of Developing Rapid Airflow Decline After Hematopoietic Cell Transplantation, Blood, 107: 2200-2207, 2006
  • Smith WP, Vu Q, Li S, Hansen JA, Zhao LP, Geraghty DE, Toward understanding MHC disease associations: Partial resequencing of 46 distinct HLA Haplotypes, Genomics, 87(5) 561-571, 2006
  • Pyo CW, Williams LM, Moore Y, Hyodo H, Li SS, Zhao LP, Sageshima N, Ishitani A, Geraghty DE, HLA-E, HLA-F and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the non-classical class I genes, Immunogenetics, 58 (4) 241-51, 2006
  • Fan W, Khalid N, Hallahan A, Olson J, Zhao LP, A statistical method for predicting splice variants between two groups of samples using GeneChip® expression array data, Theoretical Biology & Medical Modelling, 3(1): 19, 2006
  • Speelmon EC, Livingston-Rosanoff D, Li S, Vu Q, Bui J, Geraghty DE, Zhao LP, McElrath MJ, Genetic Association of the Antiviral Restriction Factor TRIM5α with HIV-1 Infection, Journal of Virology, 80: 2463-71, 2006
  • Luo W, Fan W, Xie H, Jing L, Ricicki E, Vouros P, Zhao LP, Zarbl H (Apr 2005) Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity., Chemical Research in Toxicology, 18 (4), 619-29 Abstract
  • Fan W, Pritchard JI, Olson JM, Khalid N, Zhao LP (Feb 2005) A class of models for analyzing GeneChip gene expression analysis array data., Bmc Genomics [electronic Resource], 6 (1), 16 Abstract
  • Hawn TR, Verbon A, Janer M, Zhao LP, Beutler B, Aderem A (Feb 2005) Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease., Proceedings of the National Academy of Sciences of the United States of America., 102 (7), 2487-9 Abstract
  • Yang S, Hsu L and Zhao LP, Combining asymptotically normal tests: cases studies in comparison of two groups, Journal of Statistical Planning & Inference, 133: 139-158, 2005
  • Lin M-T, Storer B, Martin PJ, Tseng LH, Grogan B, Chen PJ, Zhao LP, Hansen J, Genetic variation in the IL-10 Pathway Modulates Severity of Acute Graft-versus-Host Disease Following Hematopoietic Cell Transplantation. Synergism between IL-10 Genotype of Patient and IL-10 Receptor- β Genotype of Donor, Blood, 106: 12, 3995-4001, 2005
  • Zhang JJ, Yi T, Zhao LP (2005) Evaluation of nine strategies for analyzing a cDNA toxicology microarray data set., Journal of Biopharmaceutical Statistics, 15 (3), 403-18 Abstract
  • MacKay VL, Li X, Flory MR, Turcott E, Law GL, Serikawa KA, Xu XL, Lee H, Goodlett DR, Aebersold R, Zhao LP, Morris DR (May 2004) Gene expression analyzed by high-resolution state array analysis and quantitative proteomics: response of yeast to mating pheromone., Molecular & Cellular Proteomics : Mcp, 3 (5), 478-89 Abstract
  • Stirewalt DL, Pogosova-Agadjanyan EL, Khalid N, Hare DR, Ladne PA, Sala-Torra O, Zhao LP, Radich JP (Feb 2004) Single-stranded linear amplification protocol results in reproducible and reliable microarray data from nanogram amounts of starting RNA., Genomics, 83 (2), 321-31 Abstract
  • Bergemann TL, Laws RJ, Quiaoit F, Zhao LP (2004) A statistically driven approach for image segmentation and signal extraction in cDNA microarrays., Journal of Computational Biology : a Journal of Computational Molecular Cell Biology., 11 (4), 695-713 Abstract
  • Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A (Nov 2003) A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease., The Journal of Experimental Medicine, 198 (10), 1563-72 Abstract
  • Li SS, Khalid N, Carlson C, Zhao LP (Oct 2003) Estimating haplotype frequencies and standard errors for multiple single nucleotide polymorphisms., Biostatistics (oxford, England), 4 (4), 513-22 Abstract
  • Laws RJ, Bergemann TL, Quiaoit F, Zhao LP (Sep 2003) SignalViewer: analyzing microarray images., Bioinformatics (oxford, England), 19 (13), 1716-7 Abstract
  • Cheng C, Kimmel R, Neiman P, Zhao LP (Aug 2003) Array rank order regression analysis for the detection of gene copy-number changes in human cancer., Genomics, 82 (2), 122-9 Abstract
  • Zhao LP, Li SS, Khalid N (May 2003) A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies., American Journal of Human Genetics, 72 (5), 1231-50 Abstract
  • Serikawa KA, Xu X, MacKay V, Law GL, Zong Q, Zhao LP, Bumgarner R, Morris D, The transcriptome and its translation during the recovery from cell-cycle arrest in Saccharomyces cerevisiae, Molecular & Cellular Proteomics, 2:191-204, 2003
  • Mendez E, Cheng C, Farwell DG, Ricks S, Agoff SN, Futran ND, Weymuller EA Jr, Maronian NC, Zhao LP, Chen C (Oct 2002) Transcriptional expression profiles of oral squamous cell carcinomas., Cancer, 95 (7), 1482-94 Abstract
  • Xu XL, Olson JM, Zhao LP (Aug 2002) A regression-based method to identify differentially expressed genes in microarray time course studies and its application in an inducible Huntington's disease transgenic model., Human Molecular Genetics, 11 (17), 1977-85 Abstract
  • Thomas JG, Olson JM, Tapscott SJ, Zhao LP (Jul 2001) An efficient and robust statistical modeling approach to discover differentially expressed genes using genomic expression profiles., Genome Research, 11 (7), 1227-36 Abstract
  • Zhao LP, Prentice R, Breeden L (May 2001) Statistical modeling of large microarray data sets to identify stimulus-response profiles., Proceedings of the National Academy of Sciences of the United States of America., 98 (10), 5631-6 Abstract
  • Thomas JG, Olson JM, Tapscott SJ, Zhao LP, . An efficient and robust statistical modeling approach to discover differentially expressed genes using genomic expression profiles, Genome Research, 11:1227-36, 2001
  • Hsu L, Prentice RL, Zhao LP, Li S (2001) Incorporating age at onset information into the transmission/disequilibrium test., Genetic Epidemiology, 21 Suppl 1, S347-52 Abstract
  • Hsu L, Zhao LP, Malone KE, Daling JR (Jan 2000) Assessing changes in ages at onset over successive generation: an application to breast cancer., Genetic Epidemiology, 18 (1), 17-32 Abstract
  • Hsu L, Zhao LP, Aragaki C (May-Jun 2000) A note on a conditional-likelihood approach for family-based association studies of candidate genes., Human Heredity, 50 (3), 194-200 Abstract
  • Zhao LP, Quiaoit F, Aragaki C, Hsu L, An efficient, robust and unified method for mapping complex traits \(III\): combined linkage/linkage-disequilibrium analysis, American Journal of Medical Genetics, 84(5), 433-53, 11 1999 Abstract
  • Zhao LP, Quiaoit F, Aragaki C, Hsu L (Jun 1999) An efficient, robust and unified method for mapping complex traits (III): combined linkage/linkage-disequilibrium analysis., American Journal of Medical Genetics, 84 (5), 433-53 Abstract
  • Zhao LP, Prentice R, Shen F, Hsu L (Jun 1999) On the assessment of statistical significance in disease-gene discovery., American Journal of Human Genetics, 64 (6), 1739-53 Abstract
  • Hsu L, Prentice RL, Zhao LP, Fan J, On dependence estimation using correlated failure time data from case-control family studies, Biometrika, 86, 743-753, 1999
  • Lipsitz SR, Ibrahim JG, Zhao LP, A weighted estimating equation for missing covariate data with properties similar to maximum likelihood, American Journal of Statistical Association, 94, 1147-1160, 1999
  • Hsu L, Aragaki C, Quiaoit F, Wang X, Xu X, Zhao LP (1999) A genome-wide scan for a simulated data set using two newly developed methods., Genetic Epidemiology, 17 Suppl 1, S621-6 Abstract
  • Zhao LP, Aragaki C, Hsu L, Potter J, Elston R, Malone KE, Daling JR, Prentice R (1999) Integrated designs for gene discovery and characterization., Journal of the National Cancer Institute. Monographs (26), 71-80 Abstract
  • Aragaki C, Quiaoit F, Hsu L, Zhao LP (1999) Mapping alcoholism genes using linkage/linkage disequilibrium analysis., Genetic Epidemiology, 17 Suppl 1, S43-8 Abstract
  • Zhao LP, Quiaoit F, Aragaki C, Hsu L (Aug 1998) An efficient, robust, and unified method for mapping complex traits (II): multipoint linkage analysis., American Journal of Medical Genetics, 79 (1), 48-61 Abstract
  • Zhao LP, Aragaki C, Hsu L, Quiaoit F (Jul 1998) Mapping of complex traits by single-nucleotide polymorphisms., American Journal of Human Genetics, 63 (1), 225-40 Abstract
  • Zhao LP, Quiaoit F, Hsu L, Aragaki C (Jun 1998) Efficient, robust, and unified method for mapping complex traits (I): two-point linkage analysis., American Journal of Medical Genetics, 77 (5), 366-83 Abstract
  • Zhao LP, Hsu L, Holte S, Chen Y, Quiaoit F, Prentice RL, Combined association and aggregation analysis of case-control family data, Biometrika, 85 : 229-315, 1998
  • Zarbl H, Aragaki C, Zhao LP (1998) An efficient protocol for rare mutation genotyping in a large population., Genetic Testing, 2 (4), 315-21 Abstract
  • Holte S, Quiaoit F, Hsu L, Davidov O, Zhao LP (1997) A population based family study of a common oligogenic disease--Part I: Association/aggregation analysis., Genetic Epidemiology, 14 (6), 803-7 Abstract
  • Zhao LP, Quiaoit F, Hsu L, Davidov O, Holte S (1997) A population-based family study (II): Segregation analysis., Genetic Epidemiology, 14 (6), 945-9 Abstract
  • Zhao LP, Hsu L, Davidov O, Potter J, Elston RC, Prentice RL (1997) Population-based family study designs: an interdisciplinary research framework for genetic epidemiology., Genetic Epidemiology, 14 (4), 365-88 Abstract
  • Le Marchand L, Zhao LP, Quiaoit F, Wilkens LR, Kolonel LN (Dec 1996) Family history and risk of colorectal cancer in the multiethnic population of Hawaii., American Journal of Epidemiology, 144 (12), 1122-8 Abstract
  • Zhao LP, Lipsitz S, Lew D (Dec 1996) Regression analysis with missing covariate data using estimating equations., Biometrics, 52 (4), 1165-82 Abstract
  • Zhao LP, Koslovsky JS, Reinhard J, Bahler M, Witt AE, Provance DW Jr, Mercer JA (Oct 1996) Cloning and characterization of myr 6, an unconventional myosin of the dilute/myosin-V family., Proceedings of the National Academy of Sciences of the United States of America., 93 (20), 10826-31 Abstract
  • Zhao LP, Kristal AR, White E (Sep 1996) Estimating relative risk functions in case-control studies using a nonparametric logistic regression., American Journal of Epidemiology, 144 (6), 598-609 Abstract
  • Hsu L, Zhao LP (May 1996) Assessing familial aggregation of age at onset, by using estimating equations, with application to breast cancer., American Journal of Human Genetics, 58 (5), 1057-71 Abstract
  • Lipsitz SR, Fitzmaurice GM, Sleeper L, Zhao LP (Jun 1995) Estimation methods for the join distribution of repeated binary observations., Biometrics, 51 (2), 562-70 Abstract
  • Zhao LP, Grove JS (Sep-Oct 1995) Identifiability of segregation parameters using estimating equations., Human Heredity, 45 (5), 286-300 Abstract
  • Zhao LP, Segregation analysis of human pedigrees using estimating equations, Biometrika, 81:197-209, 1994
  • Zhao LP, Le Marchand L, Haile R, Grove J, Re: "Control for environmental risk factors in assessing genetic effects on disease familial aggregation"., American Journal of Epidemiology, 137(2), 257-60, Jan 1993 Abstract
  • Zhao LP, Grove JS, Quiaoit F (1993) Evaluation of the sampling plan used in collecting data for a study of LDL subclass pattern., Genetic Epidemiology, 10 (6), 635-40 Abstract
  • Grove JS, Zhao LP, Quiaoit F (1993) Correlation analysis of twin data with repeated measures based on generalized estimating equations., Genetic Epidemiology, 10 (6), 539-44 Abstract
  • Le Marchand L, Hankin JH, Kolonel LN, Beecher GR, Wilkens LR, Zhao LP (May-Jun 1993) Intake of specific carotenoids and lung cancer risk., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 2 (3), 183-7 Abstract
  • Zhao LP, Kolonel LN (Aug 1992) Efficiency loss from categorizing quantitative exposures into qualitative exposures in case-control studies., American Journal of Epidemiology, 136 (4), 464-74 Abstract
  • Zhao LP, Grove J, Quiaoit F (Jul 1992) A method for assessing patterns of familial resemblance in complex human pedigrees, with an application to the nevus-count data in Utah kindreds., American Journal of Human Genetics, 51 (1), 178-90 Abstract
  • Zhao LP, Lipsitz S (Apr 1992) Designs and analysis of two-stage studies., Statistics in Medicine, 11 (6), 769-82 Abstract
  • Zhao LP, Prentice R, Self S, Multivariate mean parameter estimation by using a partly exponential model, Journal of the Royal Statistical Society, (B) 54: 805-811, 1992
  • Hankin JH, Zhao LP, Wilkens LR, Kolonel LN (Jan 1992) Attributable risk of breast, prostate, and lung cancer in Hawaii due to saturated fat., Cancer Causes & Control : Ccc, 3 (1), 17-23 Abstract
  • Zhao LP, Le Marchand L (1992) An analytical method for assessing patterns of familial aggregation in case-control studies., Genetic Epidemiology, 9 (2), 141-54 Abstract
  • Prentice RL, Zhao LP (Sep 1991) Estimating equations for parameters in means and covariances of multivariate discrete and continuous responses., Biometrics, 47 (3), 825-39 Abstract
  • Zhao LP, Prentice R, Use of a quadratic exponential model to generate estimating equations for means, variances and covariances in Estimating Equations, Oxford University Press, 1991
  • Zhao LP, Thompson E, Prentice R (Aug 1990) Joint estimation of recombination fractions and interference coefficients in multilocus linkage analysis., American Journal of Human Genetics, 47 (2), 255-65 Abstract
  • Zhao LP, Prentice R, Correlated binary regression using a quadratic exponential mode, Biometrika, 77: 642-648, 1990
  • Breslow N, Zhao LP, Logistic regression for stratified case-control studies, Biometrics, 44: 891-899, 1988
  • Guo ZR, Lu JH, Zhao LP, Zhang SG, Schistosomasis Japonicum and colon cancer-An inquiry about the pathogenesis of colon cancer by using logistic regression model, Sina Academy of Epidemiology, 8, 21-24, 1987
  • Wang Y, Zhao LP, and Dudoit S, A Fine-Scale Linkage Disequilibrium Measure Based on Length of Haplotype Sharing, American Journal of Human Genetics, 78, 615-628

Profile Details

Last Updated: 8/16/2006

COS Expertise ID #1154634
Reference this profile directly: http://myprofile.cos.com/zhao1